胃肠道肿瘤中纤维粘连蛋白的分布及其与肿瘤生物学特性的关系

Through immunohistochemical technique, distribution of FN in normal mucosa, benign and malignant tumors of human gastrointestinal tract were studied. In normal and adenoma tissues, FN was found in both basement membrane (BN) and interstitial tissue. While in cancer tissue, there was a consistent decrease of BM FN content around the tumor nests particularly more apparently in cases of invading carcinoma. Statistical analysis showed that the reduction of BM FN was correlated with the degree of tumor dedifferentiation but not with the incidence of regional metastases. No association was noticed between the stroma FN and tumor behaviors. Since small blood vessels were usually delineated clearly by the staining for FN, FN might be considered as a marker in identifying the invasion of blood vessel wall by tumor cells. It is suggested that lack of BM FN in tumor tissues might be mainly due to decrease of FN synthesis by the tumor cells.     

桑菊洗剂治疗老年慢性结膜炎

老年人由于眼部组织功能衰退,抵抗力下降,易患多种外眼慢性炎症,尤以慢性结膜炎多见.患者眼部干涩、卡、痒,甚至眼眦糜烂,经久不愈.笔者用自拟中药方桑菊洗剂治疗本病61例,取得满意疗效.现小结如下.     

消疹止痒丸治疗慢性荨麻疹36例疗效观察

<正> 我科采用消疹止痒丸治疗慢性荨麻疹36例,取得了较好疗效,现总结如下。 1.临床资料 36例均为门诊病人,都是经多方治疗无效者。其中:男15例,女21例,年龄13—61岁,病程在2月—6年。 2.治疗方法 随机分为二组,治疗组36例,对照组32例,二组     

镫骨手术对耳硬化症病人高频听力的影响

1952年Rosen开始用镫骨撼动术治疗耳硬化症,取得良好的效果。以后术式不断改进,目前通常采用镫骨底板钻孔活塞植入术。术后80%～90%以上的患者效果显著,气骨导间距减小或消失。但是,耳硬化症患者术后骨导听力下降的原因仍是争论的焦点,部分学者认为耳硬化症镫骨术后高频(>4000Hz)感音神经性听力下降可能与年龄所致的老年性聋有关,与相应年龄组正常人相比其骨导下降无差异,而另一部分学者认为其原因可能是镫骨手术创伤或耳硬化症病灶侵及耳蜗所致。为研究镫骨手术对高频听力的影响,回顾分析从1985～1996年耳硬化症患者中筛选的38例患者40耳…     

高胆固醇血症对自发性高血压大鼠肾脏的损害

目的 研究高胆固醇血症在自发性高血压大鼠（ＳＨＲ）肾脏损害中的作用及其作用机制。方法 将１４只２３周龄的ＳＨＲ随机分在对照组和高胆固醇组,后者喂以４％胆固醇＋１％３号胆盐＋７％猪油混合加工成的大鼠饼干。测量每只大鼠的体重、血压、２４ｈ尿蛋白排泄量、血、尿ＮＯ及肾皮质ＴＧＦβ１－ｍＲＮＡ的表达（ＲＴ－ＰＣＲ法）。实验结束时,取其肾脏送ＨＥ光镜检查及电镜检查。结果 高胆固醇组的尿蛋白排泄高于对照组,血     

Role of Th1/Th2 cells activation in chronic hepatitis B virus infection

Clonal analysis of mndne T cells has led to the idenuncation of Z typeS of Th cells, Thl and on. Thl cells,chacterized by secreting interferon-y (Iap-Y), interleukin-2 (IL2) and tumor necrosis factor-5 (TNF-3), involved Principally in cell-mediated ~ity and play acrucial role in defending the host against intracellularPathogens such as a Vallety of yi~es. ThZ cells,secreting IL4, ms, IL-6 and ilo, mostly regulateh~ immune responSe, and may oafs Paxtial PIDtection against extracellula…