股浅动脉首期置入自膨式支架与球囊扩张成形的疗效比较

Objective To compare the mid-term clinical results of primary implantation of a selfexpanding nitinol stent and primary percutaneous transluminal angioplasty (PTA) for long range arteriosclerosis obliterans of the superficial femoral artery. Methods From December 2005 to February 2007,109 patients who had moderate-severe claudication or chronic limb ischemia (CLI)due to stenosis or occlusion of the superficial femoral artery were treated by endovascular technology. 53 patients (73 limbs) were treated by primary stenting and 56 patients (76 limbs)by PTA. We compared the clinical data of stenting group and PTA group at 6,12 and 24 months. Results The mean length of the treated segment was (16± 8)cm in the stenting group and(15±7)cm in the PTA group. At 6 months, the rate of restenosis on duplex ultrasonography was 13.7% in stenting group and 30.2% in PTA group (X2=4.09, P<0.05);at 12 months the restenosis rates were 25.5% in stenting group and 46.9% in PTA group(X2=4.75, P<0.05);at 24 months the restenosis rates on duplex ultrasonography were 38.1% in stenting group and 65.9% in PTA group(X2=6.66, P<0.01). Rutherford stages in stenting group were significantly better than those in PTA group. Conclusion In the mid-term, primary implantation of a self-expanding nitinol stent yielded results that were superior to those with PTA for arteriosclerosis obliterans or long range stenosis of the superficial femoral artery.     

医学高等院校成人继续教育《计算机基础》课程的教学改革初探

随着医疗信息化的快速发展,计算机应用能力已经成为医学专业的学生需要具备的一项基本能力。在各高校提出计算机基础课程的改革形势下,本文针对医学高等院校成人的特点就计算机基础课程的教学进行了改革初探,并取得了较好的效果。     

胃息肉中PTEN基因编码产物的变化

目的：探讨胃息肉和胃腺癌中抑癌基因PTEN编码产物的变化。方法：选取中国医科大学附属一院内镜中心活检标本和肿瘤外科术后大体标本,其中炎性息肉、增生性息肉、腺瘤型息肉、胃腺癌,每组60例,SP免疫组化检测PTEN基因编码产物的表达。结果：PTEN蛋白质表达在正常胃黏膜为100%,在炎性息肉、增生性息肉、腺瘤型息肉PTEN蛋白质的表达分别为98.3%,91.6%,78.3%;在胃腺癌中PTEN蛋白质的表达为61.6%。炎性息肉、增生性息肉和腺瘤型息肉之间差异有统计学意义（P〈0.05）,腺瘤型息肉与胃腺癌之间差异有统计学意义（P〈0.05）。结论：在炎症性息肉、增生性和腺瘤型息肉以及胃腺癌中,PTEN蛋白呈下调性表达。     

脑卒中后抑郁的相关因素分析

目的探讨脑卒中后抑郁（post—stroke depression,PSD）的发生率及相关因素。方法对248例脑卒中住院患者采用汉密尔顿抑郁量表（HAMD）、美国国会卫生研究院神经功能缺损评分（NIHSS）,统计分析抑郁发生和性别及其他因素的相关性。结果脑卒中后抑郁的发生率为37．9％,抑郁的发生与神经功能缺损程度、病灶部位有关,与患者性别无关。结论PSD是脑卒中的常见并发症,发生率较高,而且受多种因素影响。     

一种三维运动平台对肩周炎临床疗效的影响

目的:探讨使用IMOOVE三维运动平台(IMOOVE)治疗肩周炎的临床疗效。方法:从肩周炎患者中选取60例,随机分为使用IMOOVE治疗组(IMOOVE组)和关节松动术结合肌肉能量技术(MET)组(对照组)。连续治疗2周,治疗前和治疗后使用美国肩肘外科协会(ASES)评分系统进行疗效评估。结果:患者自评部分得分治疗前对照组(37.52±2.13),IMOOVE组(36.17±1.52)治疗后分别提升至(68.33±1.09)和(80.92±3.35),治疗前后差异具有显著性意义(P<0.05),IMOOVE组改善程度优于松动术组(P<0.05);两组患者治疗后肩关节活动度均有明显提高(P<0.05),IMOOVE组在改善肩外旋及内收-内旋-后伸肩关节的活动度上优于松动术组(P<0.05)。结论:关节松动术和使用IMOOVE治疗肩周炎均具有良好的临床疗效,使用IMOOVE治疗肩周炎是一种安全有效的新技术。     

3种血栓风险评估表对老年下肢骨折病人术后并发深静脉血栓的预测价值

目的 探讨深静脉血栓风险评分量表(Wells)、静脉血栓栓塞症风险评估量表(Caprini)、深静脉血栓危险因素评估量表(Autar)对老年下肢骨折病人术后并发深静脉血栓(DVT)的预测价值. 方法 选取2018年1月至2019年1月新疆医科大学第七附属医院收治的下肢骨折并接受手术治疗的96例老年病人为研究对象,根据病...     

血府逐瘀汤治疗下肢动脉硬化闭塞症临床观察

目的观察血府逐瘀汤（XFZY）和前列地尔脂微球载体E1（PGE1）注射液治疗下肢动脉硬化闭塞症（ASO）的疗效。方法动脉狭窄程度及踝/肱指数（ankle-brachial index,ABI）。结果 XFZY组显效率为82.9%,对照组为54.8%（P〈0.05）;两组治疗后凝血功能、动脉狭窄程度等指标均有改善,XFZY组较治疗前可明显提高ABI（P〈0.05）。结论血府逐瘀汤和前列地尔脂微球载体制剂注射液合用能显著改善ASO患者肢体缺血症状,增加组织灌流量。     

丙戊酸钠与左乙拉西坦比较治疗儿童癫痫有效性和安全性的系统评价与Meta分析

目的 比较丙戊酸钠与左乙拉西坦治疗儿童癫痫的有效性与安全性,重点关注该2种药物对患儿认知功能的影响。方法 计算机检索The Cochrane Library、PubMed、Embase、中国知网、万方数据和中国生物医学文献数据库,检索时间均从建库至2021年11月30日。由2名研究者根据纳入排除标准独立进行文献筛选、数据提取和质量评价,并交叉核对,采用RevMan5.3软件进行Meta分析。结果 共纳入7篇研究,其中3篇为随机对照实验（RCT）,4篇为队列研究。共涉及629例患儿。Meta分析结果显示：有效性方面,使用左乙拉西坦单药治疗与丙戊酸钠组相比,无癫痫发作人数更多[OR=2.33,95%CI(1.47,3.70)]、≥50%反应率更高[OR=2.40,95%CI(1.51,3.81)];认知功能方面,左乙拉西坦组与丙戊酸钠组相比,韦氏儿童智力量表中言语智商（VIQ）[MD=1.60,95%CI(0.6,2.60)]、操作智商（PIQ）[MD=3.73,95%CI(2.86,4.59)]和全量表智商（FIQ）[MD=1.71,95%CI(0.83,2.59)]、蒙特利尔认知评估量...     

非酒精性脂肪性肝病患者血清瘦素和脂联素与胰岛素抵抗的关系

Objective To investigate the serum leptin and adiponectin levels in nonalcoholic fatty liver disease (NAFLD) patients, and their relationship with insulin resistance. Methods A total of 120 cases were enrolled and divided into two groups: NAFLD group (n = 60) and normal control group (n = 60). The serum levels of leptin and adiponectin were measured by EL1SA. The body mass index (BMI), waist-to-hip ratio (WHR), triglyceride (TG), total cholesterol (Tchol), high-density lipoprotein cholesterol (HDL-C), aspartate aminotransferase (AST), alanine aminotransferase (ALT), gamma-glutamyl transpeptidase (GGT), fasting blood glucose (FBG) and HOMA-IR (homeostasis model assessment insulin resistance) were detected and analyzed. Results Compared with control group, the serum leptin level in NAFLD group was Significantly higher [(12.37 ± 1.99) μg/Lvs (5.20 ± 1.03)μg/L,P<0.01], while the serum adiponectin level was significantly lower [(12.69 ± 2.83) mg/L vs (22.83 ± 4.61) mg/L, P < 0.01]. HOMA-IR was also much higher in NAFLD group than that in control group[(4.86 ± 0.63) vs (1.91 ± 0.41), P < 0.01]. Logistic regression analysis showed that leptin was positively correlated with WHR ( P = 8.175, P < 0.01), HOMA-IR ( P = 0.974, P < 0.01 ), FBG ( β = 0.564, P < 0.01). In contrast, adiponectin inversely associated with HOMA-IR ( β = -0.495, P < 0.01 ) and BMI ( β = -0.314, P < 0.01) respectively. Conclusions The increased serum leptin level and decreased serum adiponectin level in NAFLD patients independently associated with HOMA-IR.