大学生主观家庭经济地位人际适应家庭功能与手机成瘾的关系

探讨主观家庭经济地位和人际适应在家庭功能对大学生手机成瘾关系中的链式中介作用,为高校制定合理干预措施改善大学生手机成瘾现状提供科学依据.方法 采用方便抽样法抽取湖南省2所高校758名大一学生,用家庭关怀指数问卷、大学生人际适应性分量表、青少年主观社会经济地位量表、手机成瘾倾向量表进行调查.结果 相关分析表明,手机成瘾与主观家庭经济地位和人际适应得分均呈负相关(r值分别为-0.07,-0.33,P值均<0.01),与家庭功能类别呈正相关(r=0.18,P<0.01).中介作用检验结果表明,家庭功能通过人际适应到手机成瘾、家庭功能通过主观家庭经济地位和人际适应到手机成瘾、家庭功能直接到手机成瘾这3条路径有统计学意义(P值均<0.05),总效应为2.95,中介效应为1.48.结论 主观家庭经济地位和人际适应在家庭功能对大学生手机成瘾关系中起链式中介作用.     

超声刀在腮腺手术中的应用

目的：探讨超声刀在在腮腺手术中的应用效果。方法：收集腮腺手术病例63例,将其随机分为两组,使用Focus超声刀完成腮腺手术33例（超声刀组）,另选取电刀手术30例设为对照（电刀组）。两组患者均在气管插管全麻下行腮腺浅叶切除,术式一致。对两组总手术时间、暴露腮腺到切除腮腺浅叶的时间、术中出血量、术后引流量、术后并发症等进行对比研究。结果：超声刀组所得出的各项数据均低于传统电刀组,差异有统计学意义（P＜0．05）。结论：在腮腺手术中使用超声刀方便、安全、效果好。     

阿维A胶囊联合胸腺肽片治疗银屑病30例的疗效观察

目的观察阿维A胶囊联合胸腺肽片治疗寻常型银屑病的疗效和安全性。方法寻常型银屑病患者60例,按就诊先后顺序分为两组,治疗组30例口服阿维A胶囊联合胸腺肽片,对照组30例单服阿维A胶囊。用药后第4、8、12周观察疗效。结果治疗组30例总有效率为86.7%,明显高于对照组的60.7%,治疗组疗效优于对照组（P〈0.05）。治疗组有76.7%的患者出现不同程度的皮肤黏膜干燥症状,对照组为92.9%,两组比较差异有统计学意义（P〈0.05）。结论阿维A胶囊联合胸腺肽片治疗寻常型银屑病疗效好,而且安全。     

铅暴露对大鼠参考记忆和工作记忆的影响

BACKGROUND： Studies have demonstrated that lead exposure can result in cognitive dysfunction and behavior disorders. However, lead exposure impairments vary under different experimental conditions.
OBJECTIVE： To detect changes in spatial learning and memory following low-level lead exposure in rats, in Morris water maze test under the same experimental condition used to analyze lead exposure effects on various memory types and learning processes.
DESIGN AND SETTING： The experiment was conducted at the Animal Laboratory, Institute of Psychology, Chinese Academy of Science between February 2005 and March 2006. One-way analysis of variance （ANOVA） and behavioral observations were performed. MATERIALS： Sixteen male, healthy, adult, Sprague Dawley rats were randomized into normal con-trol and lead exposure groups （n = 8）.
METHODS： Rats in the normal control group were fed distilled water, and those in the lead exposure group were fed 250 mL of 0.05% lead acetate once per day. At day 28, all rats performed the Morris water maze test, consisting of four phases： space navigation, probe test, working memory test, and visual cue test.
MAIN OUTCOME MEASURES： Place navigation in the Morris water maze was used to evaluate spatial learning and memory, probe trials for spatial reference memory, working memory test for spatial working memory, and visual cue test for non-spatial cognitive function. Perkin-Elmer Model 300 Atomic Absorption Spectrometer was utilized to determine blood lead levels in rats.
RESULTS： （1） In the working memory test, the time to reach the platform remained unchanged between the control and lead exposure groups （F（1,1） = 0.007, P = 0.935）. A visible decrease in escape latencies was observed in each group （P = 0.028）. However, there was no significant difference between the two groups （F（1,1） = 1.869, P = 0.193）. The working memory probe test demonstrated no change between the two groups in the time spent in the target quadrant during the working memory probe test （F（1,1） = 1.869, P = 0.193）. However, by day 4, differences were observed in the working memory test （P 〈 0.01）. （2） Multivariate repetitive measure and ANOVA in place navigation presented no significant difference between the two groups （F（1,1） = 0.579, P = 0.459）. （3） Spatial probe test demonstrated that the time to reach the platform was significantly different between the two groups （F（1,1） = 4.587, P = 0.048）, and one-way ANOVA showed no significant difference in swimming speed between the two groups （F（1,1） = 1.528, P = 0.237）. （4） In the visual cue test, all rats reached the platform within 15 seconds, with no significant difference （F（1,1） = 0.579, P = 0.459）. （5） During experimentation, all rats increased in body mass, but there was no difference between the two groups （F（1,1） = 0.05, P = 0.943）. At day 28 of 0.05% lead exposure, the blood lead level was 29.72 μg/L in the lead exposure group and 5.86 μg/L in the control group （P 〈 0.01）.
CONCLUSION： The present results revealed low-level lead exposure significantly impaired spatial reference memory and spatial working memory, but had no effect on spatial learning.     

旋光法测定甲磺酸培氟沙星葡萄糖注射液中葡萄糖含量

目的用旋光法测定甲磺酸培氟沙星葡萄糖注射液中葡萄糖含量。方法直接取样测定甲磺酸培氟沙星葡萄糖注射液的旋光度,计算葡萄糖含量。结果葡萄糖质量浓度在0.03～0.07g/mL范围内与旋光度线性关系良好,线性回归方程Y=47.473X＋0.0246,r=0.9998（n=5）;平均回收率为100.28%,RSD为0.51%（n=9）。结论旋光法简便、准确、可靠,可用于甲磺酸培氟沙星葡萄糖注射液的质量控制。     

中西医结合治疗急性放射性肺炎临床观察

目的观察中西医结合方法治疗急性放射性肺炎的临床效果。方法 80例患者随机分为两组,治疗组采用滋阴清热化瘀中药联合激素抗生素,对照组单纯采用激素、抗生素治疗;治疗前后观察放射性肺炎评级情况、中西医症状疗效、X线胸片疗效、检测治疗前后患者血清肿瘤坏死因子α(TNF-α),转化生长因子β(TGF-β)水平。结果治疗后治疗组放射性肺炎等级评价,中西医症状治疗效果均明显优于对照组;治疗后两组血清TNF-α、TGF-β均有不同程度下降,治疗组下降更显著。结论中西医结合治疗放射性肺炎疗效确切,较之单纯西药治疗效果更明显。     

鼻咽癌常规放疗与调强放疗的临床研究

目的:比较鼻咽癌不同放疗方式的远期并发症发生情况及远期疗效.方法:采用门诊随访、电话随访、随访信等方式,调查2003-01-01-2006-07-31在我院行放射治疗的145例鼻咽癌患者临床资料,分析不同放疗方式远期并发症发生率及远期疗效.其中常规放疗68例,调强放疗77例.随访的远期并发症包括口干、张口受限、放射性龋齿、听力下降、颈部纤维化等.所有的远期并发症均视为二分类变量.结果:常规放疗组和调强放疗组口干、颈部纤维化的发生率分别为94.1％和61.0％(x2=22 012,P＜0.01)、41.2％和15.6％(x2=11.839,P=0.001),张口受限、放射性龋齿、听力下降的发生率分别为35.3％和26 0％(x2 =1.484,P=0.223)、35.3％和28.6％(x2=0.753,P=0.385)、52.9％和40.0％,x2 =2.846,P=0.092.常规放疗组和调强放疗组5年生存率分别为60.5％和77.4％,x2=4.320,P=0.038.结论:鼻咽癌调强放疗远期并发症的发生率低于常规放疔,远期疗效明显优于常规放疔,但调强放疔仍存在部分远期并发症,影响患者的生存质量.     

盐酸帕洛诺司琼合成路线图解

帕洛诺司琼(palonosetron,1),化学名为(3aS)-2-[(3S)-1-氮杂二环[2.2.2]辛烷-3-基]-2,3,3a,4,5,6-六氢-1-氧代-1H-苯并[de]异喹啉,是由瑞士Helsinn公司研制的5-HT,受体拮抗剂,其盐酸盐于2003年7月首次在美国上市,商品名Aloxi(阿乐喜),临床用于预防中度或高度致吐性化疗引发的急性和迟发性恶心呕吐.本品半衰期长(40h),与受体的亲合力是其他5-HT,受体拮抗剂的100多倍,美国综合癌症网(NCCN)推荐帕洛诺司琼为预防化疗引发的恶心和呕吐的首选药物[1-3].     

心肌梗死超急性期50例诊断分析

目的探讨心电图和超声心动图两种方法诊断心肌梗死超急性期的灵敏性、准确性。方法将50例心肌梗死超急性期患者随机分为心电图组和超声心动图组,比较确诊、漏诊、误诊率及对心肌梗死定位、并发症的检测和评估。结果超声心动图组确诊率（84%）明显高于心电图组（56%）,差异具有统计学意义（P〈0.05）。结论超声心动图不仅能对心肌梗死超急性期迅速作出准确诊断,还能评估心肌梗死面积、心肌受损程度、心肌存活性、左心功能、机械并发症,超声心动图组诊断方法优于心电图组。     

有关HDL在心脏病中作用的依据

为什么高密度脂蛋白(HDL)不能象低密度脂蛋白(LDL)那样可防御动脉粥样硬化的发生,这一有关胆固醇的疑问也许不久即可获得解答,因为在美国心脏协会的达拉斯会议上,有学者提供的数据表明,一种被称为清除剂受体BI(SR-BI)的HDL受体