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目的:探讨氯胺酮对糖尿病周围神经病变大鼠脊髓的保护作用。方法:对糖尿病周围神经病变大鼠腹腔注射氯胺酮,于注射后第1、3、5、8周观察其行为学及神经传导速度的改变;应用免疫组化方法和图象分析法检测胶质纤维酸性蛋白(glial fibrillaryacidic protein,GFAP)在脊髓背角的表达情况。结果:糖尿病周围神经病变引起大鼠机械性触诱发痛;大鼠脊髓背角组织中GFAP的表达明显增强;其腹腔注射氯胺酮后GFAP在脊髓背角的表达减弱。结论:糖尿病大鼠周围神经病变引起的神经痛与脊髓背角胶质细胞激活有关。而氯胺酮可明显抑制脊髓背角胶质细胞的激活,减轻糖尿病神经痛。 相似文献
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目的通过评价氧化亚氮和异氟醚对大鼠耳蜗RNA产量的影响,探讨其对耳作用的可能机制。方法30只健康Wistar大鼠随机分为3组(n=10),对照组(C组)持续吸入50%O2 3 h;氧化亚氮组(N组)持续吸入50%氧化亚氮.50%O23h;异氟醚组(Ⅰ组)持续吸入2.5%异氟醚-50%O2 3 h。采用TRIzol和RNeasy法分别提取耳蜗的RNA,用分光光度计测定RNA的产量,用电泳检测其质量,测定RNA的产量。结果与C组比较,N组单侧耳蜗RNA产量降低(P〈0.05),Ⅰ组单侧耳蜗RNA产量差异无统计学意义(P〉0.05)。RNA纯度高,总RNA无降解。结论吸入50%氧化亚氮3h可降低大鼠耳蜗RNA产量,吸入2.5%异氟醚3 h对其无影响。 相似文献
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早孕妇女择期行人工流产手术,常因为心理恐惧和疼痛刺激导致极度不适,出现血压下降,心率减慢,面色苍白,四肢厥冷,术后恶心呕吐,甚至休克。经对比观察静脉丙泊酚伍用不同镇痛药与清醒状态下行人工流产术的不同效应,现将结果报道如下。 相似文献
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目的 :动态观察异氟醚吸入麻醉大鼠不同时期脊髓一氧化氮合酶 (NOS)活性和一氧化氮 (NO)产量变化 ,探讨异氟醚的麻醉镇痛作用机制。方法 :4 0只SD大鼠随机等分为 5组 :对照组、诱导期组、麻醉期组、恢复期组和清醒期组 ,分光光度法测定不同麻醉时期脊髓NOS活性和NO产量。结果 :脊髓NOS活性和NO产量在诱导期组即开始下降 (P <0 .0 5或P <0 .0 1) ;麻醉期组降至最低水平 (P <0 .0 1) ;而恢复期组又开始上升 ,但仍明显低于对照组水平 ;清醒期组基本恢复至对照组水平 (P >0 .0 5 )。且麻醉深度变化与NOS活性及NO产量变化相关。结论 :异氟醚可明显抑制脊髓NOS活性和NO产量 ,提示异氟醚可通过抑制NOS活性和NO产量而发挥麻醉镇痛效应 ,麻醉深浅与抑制的程度有关 相似文献
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目的 观察鞘内注射血小板活化因子(platelet-activating factor,PAF)受体拮抗剂BN52021和BN50730对脊神经结扎(spinal nerve ligation,SNL)大鼠痛敏和脊髓原癌基因c-fos表达的影响,探讨脊髓PAF在神经病理性疼痛机制中的作用.方法 雄性SD大鼠48只,鞘内置管,随机分为6组.假手术组(sham组),12只;SNL组,12只,制作SNL模型;DMSO(0.1%二甲基亚砜生理盐水,5μl)对照组、BN52021(100 μg/5μl)治疗组、BN50730(100 μg/5 μl)治疗组和BN52021(100 μg/2.5 μl)+BN50730(100 μg/2.5μl)治疗组,每组6只,制作SNL模型,DMSO对照组和3个治疗组鞘内注射给药,每天1次,连续给药7 d;第7天测各组大鼠机械缩爪阈值和辐射热缩爪潜伏期,放射免疫分析检测脊髓PAF含量,免疫组织化学染色检测脊髓c-fos的表达.结果 SNL神经损伤诱发大鼠触觉异常痛敏和热痛敏,机械缩爪阈值和辐射热缩爪潜伏期下降(P<0.05),脊髓PAF含量升高(P<0.05),脊髓c-fos表达增强(P<0.05);BN52021和BN50730明显减轻大鼠触觉异常痛敏和热痛敏并抑制脊髓c-fos的表达增强(P<0.05).结论 内源性PAF可能参与SNL神经损伤疼痛机制,PAF的两类结合位点均介导痛觉信号传导,PAF受体拮抗剂可应用于治疗SNL神经损伤诱发的慢性疼痛. 相似文献
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The possible mechanism of inhalation anesthetics on the internal auditory impairment of the rat was investigated by determining the effect of nitrous oxide (N2O) and isoflurane on the total RNA yield from the cochlea of the rats. Thirty healthy Wistar rats were randomly divided into 3 groups: group C (control group, n=10) with a 3-h unremitting inhalation of 50% 02, group N (experiment group, n= 10) with a continuous inhalation of 50% N20+50% O2for 3 h, and group I (experiment group, n=10) with a 3-h sustained inhalation of 2.5% isoflurane. The TRIzol in combination with RNeasy was used to respectively extract the total RNA from cochlea of rats in the 3 groups. Spectrophotometry was used to detect total RNA yield and electrophoresis to detect the quality. The total RNA extracted from the cochlea of the rats in the groups C and N was 7.69 and 6.51 μg, respectively. There was a 15% decrease in the N group as compared with group C. The total RNA from the rats in the group I was 7.32μg, and there was hardly any change in the group as compared with the group C. The value of A260/A280 in groups C, N and I was 2.07, 2.04 and 2.04, respectively, showing a very high RNA purity. The result of gel electrophoresis suggested that there was no degradation in the total RNA. It was suggested that the interference of N20 on the cochlear RNA yield might be one of the reasons which cause an injury of the ear. The isoflurane shows no harm on the hearing. 相似文献