NON-SPECIFIC RESPONSIL OF SERUM GROWTH HORMONE TO THYROTROPIN-RELEASING HORMONE IN DIABETICS

It is well known that growth hormone (GE) secretion and regulation in diabetics are abnormal. In order to evaluate the response of GH to nonphysiological stimuli in diabetics, a thyrotropin-releasing hormone (TRH) test (500 micrograms by IV bolus injection) was carried out in 12 patients with insulin-dependent diabetes (IDD, 6 males and 6 females). 11 noninsulin-dependent diabetes (NIDD, 5 males and 6 females), and 10 normal controls (6 males and 4 females). The results showed that the basal serum GH levels in diabetics were higher than that in normal controls and it was even higher in IDD than in NIDD. Following the TRH stimulus, the mean peak level of GH in IDD was the highest among the three groups, the differences being statistically significant (F = 9.323, P less than 0.01). It was concluded that a nonspecific response to TRH of GH did occur in IDD, and the peak values were even higher in female than in male subjects. A negative correlation existed between the GH peak values and the age of the patients as well as in the controls. This supported the view that GH responsiveness to TRH has a tendency of progressive decline with age. However, no significant correlation was found between the peak value of GH and the blood glucose level or the microangiopathic complications. The mechanism of TRH stimulation on GH release in diabetics is discussed.     

左向右分流型先天性心脏病合并心力衰竭患儿β2-微球蛋白水平变化

目的研究左向右分流型先天性心脏病合并心力衰竭（心衰）患儿β2-微球蛋白（MG）水平变化。方法采用放射免疫法检测血清β2-MG,彩色多普勒超声诊断仪测量左室射血分数（LVEF）。选择先天性心脏病（左向右分流）合并心衰84例（心衰组）及正常健康儿童30例（对照组）,分别测定其LVEF、血清肌酐（Cr）、β2-MG水平,并进行对比分析。结果心衰组血β2-MG水平显著高于对照组（P〈0.01）,在心衰患儿中对比不同程度心衰患儿各指标发现,血清β2-MG水平随心衰加重而显著升高,与心衰严重程度呈显著正相关（P〈0.01）,轻度心衰组与健康对照组Cr水平比较无明显升高,而轻度心衰组与健康对照组β2-MG水平比较有明显升高。在心衰患儿中,LVEF与β2-MG呈负相关（P〈0.01）;β2-MG与Cr水平呈正相关（P〈0.01）。结论β2-MG在反映肾小球滤过功能方面较Cr敏感,与心衰严重程度呈正相关;检测心衰患儿的血清β2-MG水平,可作为肾脏损伤的早期监护,为临床及时采取适当的治疗措施,为判断心肾损害严重程度及预后提供依据。     

我国艾滋病防治工作中应注意的几个问题

艾滋病（AIDS）已在全球范围内广泛流行，自1981年美国首次报道艾滋病后，至今全球已有210多个国家报告发现AIDS。目前全球艾滋病病毒（HIV）携带者或艾滋病患者总数约4000多万，已有4000多万人因艾滋病而死亡。我国自1986年6月发现第1例艾滋病外籍感染者以来，已有48％的县报告了HIV感染者或AIDS病人，现存HIV感染者和AIDS患者84万。为了有效地防止艾滋病在我国蔓延，     

亚健康状态肾虚证的证候特征分析

目的：探讨亚健康状态肾虚证的证候特征。方法：首先让就诊人员填写亚健康状态调查问卷,判断亚健康状态：然后根据现场调查医师掌握的中医四诊资料,按有关肾虚证的辩证标准进行辨证;采用SPSS13．0对数据进行统计学分析。结果：亚健康状态肾虚证的主要证候特点有腰部酸痛、腿膝酸软、疲倦乏力、失眠、脱发、手足心热、头晕、咽干、性欲减退、大便干、盗汗、畏寒、手足冷、夜尿多、耳鸣等;舌象以舌质红为多见,其次为舌质淡红、舌质淡、舌质暗红;脉象以脉细为多见,其次为脉弦细、脉细弱。结论：从亚健康状态入手研究肾虚证的证候特征具有一定的科学性和实用性。     

产妇,别依赖腹带收腹

小妹做产后,为了保持优美的体形,月子里就带上腹带,穿上紧身的内裤,认为这样就可以把撑肝的腹部收回去。     

脑利钠肽联合红细胞分布宽度在婴儿川崎病中的应用价值

目的:深入探讨脑利钠肽和红细胞分布宽度在婴儿川崎病冠状动脉病变中的应用价值,预防和减少冠状动脉病变,从而改善川崎病患儿的预后。方法:回顾性分析2018年1月—2019年12月在郑州大学附属儿童医院收治的已经出院确诊为婴儿川崎病的113例患儿的临床资料,并对其进行总结分析。结果:CAL组WBC、RDW和BNP水平显著升高,差异有统计学意义。WBC、RDW和BNP水平增高是CAL的独立危险因素。RDW≥13.4%预测川崎病合并冠脉病变的灵敏度为74.4%,特异度为75.7%,ROC曲线下的面积为0.757。BNP≥325 pg/m L预测川崎病合并冠脉病变的灵敏度为90.7%,特异度为74.3%,ROC曲线下的面积为0.862。结论:BNP、RDW升高可作为预测川崎病患儿合并CAL的危险因素。     

二甲双胍对非糖尿病肥胖的卵巢癌患者化疗耐药性和生存期的影响#br#

Objective?To analyze the effects of metformin on chemotherapy resistance and survival time of non-diabetic obese patients with ovarian cancer. Methods?Clinical data of 150 patients with ovarian cancer complicated with non-diabetic obesity treated in Department of Gynecologic Oncology of Linyi Cancer Hospital were retrospectively analyzed between January 2016 and November 2018. Patients were divided into groups A and B and placebo group (each n=50) according to different treatments. Chemotherapy sensitivity and drug resistance, serum human insulin-like growth factor 1 (IGF-1), human insulin-like growth factor receptor (IGF-1R), serine/threonine protein kinase (AKT) and incidence rates of drug side effects during treatment were compared. After 3 years of follow-up, survival time was compared among patients with different treatment methods. Results?Drug resistance rate of 24.00% in group A and 18.00% in group B were both lower than 44.00% in placebo group (P<0.05). After treatment, IGF-1, IGF-1R and AKT in groups A and B were lower than those in placebo group, and above indicators in group B were lower than those in group A and placebo group (P<0.05). There were no significant differences in incidence rates of side effects among three groups of different drug treatment regimens (P>0.05). Overall survival rate of 76.00% (38/50) in group A and 82.00% (41/50) in group B, were higher than 68.00% (34/50) in placebo group (P<0.05). Median survival time of 32 months in group B was longer than 29 months in group A and 25 months in placebo group. Conclusion?Metformin can promote tumor cell apoptosis, improve tumor microenvironment, reduce drug resistance and prolong survival time by regulating levels of IGF-1 and IGF-1R in non-diabetic obese patients with ovarian cancer.     

磷酸肌酸钠对阿霉素所致心肌损伤大鼠急性期心肌组织连接蛋白43表达的影响

目的探讨磷酸肌酸钠对阿霉素所致心肌炎大鼠急性期心肌组织连接蛋白43(Cx43)表达的影响,探讨磷酸肌酸钠对阿霉素所致心肌炎并发心律失常发挥作用的机制。方法 60只雄性SD大鼠分为磷酸肌酸钠干预组,阿霉素组和正常对照组,观察大鼠的一般情况,第14天无痛苦处死全部大鼠并留取心脏。免疫组织化学法检测Cx43蛋白水平表达,并进行定量分析。结果①阿霉素组大鼠心室肌组织炎症病灶中变性、坏死周围心肌细胞Cx43表达明显减弱,甚至阴性,分布不规则,Cx43蛋白表达明显低于对照组,差异有统计学意义(P<0.01)。②磷酸肌酸钠组Cx43蛋白表达明显高于模型组,差异有统计学意义(P<0.01)。结论阿霉素所致心肌损伤大鼠急性期心肌组织Cx43蛋白表达下降。磷酸肌酸钠能明显提高CVB心肌炎大鼠急性期心肌组织Cx43蛋白表达。     

小四五颗粒对糖尿病肾病大鼠血浆蛋白质图谱的影响

目的：探讨小四五颗粒对糖尿病肾病（ DN）大鼠血浆蛋白质图谱的影响。方法将24只大鼠随机分为正常对照组、模型组和治疗组各8只,正常对照组不处理,模型组和治疗组采用链脲佐菌素（ STZ ）诱导的方法制备DN大鼠模型,造模成功后,治疗组给予小四五颗粒灌胃,模型组与正常对照组给予等体积生理盐水灌胃。4周后采用双向凝胶电泳技术分离各组的血浆蛋白,银染后对凝胶图像进行差异表达分析。结果与正常对照组相比,模型组血浆蛋白质银染双向凝胶电泳图谱中高表达的蛋白质斑点54个,低表达的蛋白质斑点19个;小四五颗粒治疗组上述差异表达的蛋白质斑点有16个较模型组明显恢复。结论小四五颗粒治疗组16个差异表达的蛋白质斑点可能与DN的发生发展密切相关。