中西医结合治疗慢性肺心病心功能不全临床观察

笔者采用中西医结合治疗慢性肺源性心脏病合并心功能不全33例，并与单纯西药治疗的28例进行疗效对比，现报道如下。     

胃癌组织中S100P表达的临床意义及其机制探讨

Objective To investigate the impact of the expression of S100P on the prognosis and tumor chemosensitivity in patients with resectable gastric cancer and its mechnisms. Methods The expression of S100P was analyzed in 121 resected primary gastric cancer tissues by using tissue array of immunohistochemistry excised from January 2003 to December 2007. The patients received adjuvant chemotherapy with oxaliplatin. The pEGFP-SlOOP plasmid was constructed and was transfected into BGC823 cell line to establish gastric cancer cell line with over-expression of human S100P, BGC823-S100P. The expression level of S100P was determined by real-time PCR and Western blot assay. The chemosensitivity of BGC823-S10OP cell line to oxaliplatin was detected by 3-( 4, 5-Dimethylthiazol-2-yl )-2, 5-diphenyltetrazolium (MTT) assay. Results The S100P was positively expressed in 64 tumors(52. 9% , 64/ 121). Although there was no significant relation between the expression of S100P and tumor T staging( P = 0. 683), N staging( P = 0. 472), M staging (P = 0. 770 ) and differentiation (P = 0. 553), Wilcoxon test showed that the 5-year cumulative survival rate of patients with positive S100P expression was significantly higher than that of patients with negative expression (20.3% vs. 3.5%, P =0.034). Furthermore, overexpressed of S100P was found in the BGC823 cell line, BGC823-S100P. The mRNA and protein level of S1O0P in pEGFP transfected BGC823-S100P cell lines were significantly higher than those in control group (8.42±1.38 ra. 0.83±0.11 and 3. 52±0.48 vs. 0. 97±0. 19,all P <0. 05). It indicated with MTT assay that the half-inhibitory concentration(IC50) to oxaliplatin decreased in BGC823-S1OOP cells, and was significantly lower than that in vector-only transfected cells[ ( 142±16) mg/L vs. (266± 11 ) mg/L,P = 0. 032]. Conclusions S100P may also be a potentially novel independent prognostic factor in gastric cancer patients following curative resection. And it could improve the cumulative survival of the patients through enhancing the chemosensitivity of tumor cell line to oxaliplatin.     

丹参酮胶囊联合维胺酯维E乳膏治疗寻常性痤疮疗效观察

目的观察丹参酮胶囊联合维胺酯维E乳膏治疗寻常性痤疮的疗效。方法76例患者随机分为应用丹参酮胶囊联合维胺酯维E乳膏治疗（治疗组）40例和应用罗红霉素胶囊治疗（对照组）36例，并进行疗效观察，两组均14天为一个疗程。结果治疗组治疗2周后总有效率为90.0％，对照组为72.3％，两组比较差异有显著性（X^2=5.76，P〈0.05）。结论丹参酮胶囊联合维胺酯维E乳膏治疗寻常性痤疮有较好的疗效。     

软组织病小铍针疗法临床应用举要

近年来，笔者采用小铍针治疗部分软组织劳损性疾病，取得了良好疗效。该疗法将针刺、手术和局部封闭有机地结合起来，取长补短，有效地解决了部分软组织病的治疗难题，现报道如下。     

人参三醇皂甙促进人白细胞介素6转译的生物学效应

将PHA激活淋巴结细胞作为研究对象,观察了人参三醇皂甙(PTGS)对人白细胞介素6(IL-6)分泌的促进效应。应用同位素示踪技术观察细胞RNA合成和蛋白质合成与IL-6分泌的关系,结合IL-6mRNA体外转译体系,探讨了PTGS促IL-6诱生的机理。结果表明PTGS对IL-6基因的转录环节无明显作用,但对IL-6基因的转译环节具明显促进效应。     

胃囊肿与溃疡并存一例报告

患者,男,47岁。中上腹无规律疼痛2年余,加重1周,伴恶心、嗳气、反酸。临床检查:心肺正常,中上腹部压痛明显,无反跳痛,未扪及肿块。实验室检查无特殊。X线钡餐检查:胃内有少量空腹潴留液,胃体小弯侧见约0.8×1 cm的突出     

~(32)P治疗4247例皮肤血管瘤临床分析

皮肤血管瘤分草莓状、海绵状和混合性血管瘤,发生于皮肤血管及其附属结构组织的良性肿瘤,是一种主要表现为病损区血管的数量、结构及功能显著异常性疾病.我们用32P治疗皮肤血管瘤共4 247例,疗效明显,现报告如下.     

神经外科病人静滴甘露醇致肾功能损害的流行学研究

为研究甘露醇导致肾功能损害的影响因素，本文收集１９９６年神经外科信院病例２５０例，利用协力医学软件和ＳＰＳＳ／ＰＣ＋软件建立数据库，进行描述性分析及单因素和Ｌｏｇｉｓｔｉｃ回归分析。结果表明：男性、高龄、脑出血和脑外伤、冬季和春季、原已存在潜在肾功能损害因素（如肾脏病、糖尿病、高血压等）、愈后不良患者等，在使用甘露醇治疗时，肾功能损害的发生率明显升高。本文并就统计结果进行了分析和讨论。