Long-Term Clinical Effect of Tangyiping Granules(糖异平颗粒)on Patients with Impaired Glucose Tolerance

Objective: To evaluate the long-term clinical effect of Tangyiping Granules(糖异平颗粒, TYP) on patients with impaired glucose tolerance(IGT) to achieve normal glucose tolerance(NGT) and hence preventing them from conversion to diabetes mellitus(DM). Methods: In total, 127 participants with IGT were randomly assigned to the control(63 cases, 3 lost to follow-up) and treatment groups(64 cases, 4 lost to follow-up) according to the random number table. The control group received lifestyle intervention alone, while the patients in the treatment group took orally 10 g of TYP twice daily in addition to lifestyle intervention for 12 weeks. The rates of patients achieving NGT or experiencing conversion to DM as main outcome measure were observed at 3, 12, and 24 months after TYP treatment. The secondary outcome measures included fasting plasma glucose(FPG), 2-h postprandial plasma glucose(2h PG), glycosylated hemoglobin(Hb A1c), fasting insulin(FINS), 2-h insulin(2hI NS), homeostatic model assessment of insulin resistance(HOMA-IR), blood lipid and patients' complains of Chinese medicine(CM) symptoms before and after treatment. Results: A higher proportion of the treatment group achieved NGT compared with the control group after 3-, 12- and 24-month follow-up(75.00% vs. 43.33%, 58.33% vs. 35.00%, 46.67% vs. 26.67%, respectively, P0.05). The IGT to DM conversion rate of the treatment group was significantly lower than that of the control group at the end of 24-month follow-up(16.67% vs. 31.67%, P0.05). Before treatment, FPG, 2h PG, Hb A1 c, FINS, 2h INS, HOMA-IR, triglyceride(TG), total cholesterol, low- and high-density lipoprotein cholesterol levels had no statistical difference between the two groups(P0.05). After treatment, the 2hP G, HbA 1c, HOMA-IR, and TG levels of the treatment group decreased significantly compared with those of the control group(P0.05). CM symptoms such as exhaustion, irritability, chest tightness and breathless, spontaneous sweating, constipation, and dark thick and greasy tongue were significantly improved in the treatment group as compared with the control group(P0.05). No severe adverse events occurred. Conclusion: TYP administered at the IGT stage with a disciplined lifestyle delayed IGT developing into type 2 DM.     

中西医结合治疗糖尿病肾病Ⅲ期临床研究

目的:观察益气养阴、清热活血中药联合西药对糖尿病肾病(Diabetic Nephropathy,DN)Ⅲ期的临床干预疗效,分析并探讨其作用机制。方法:采用随机、对照的方法,将80例患者随机分为2组,西药治疗组40例,中西医结合组40例,观察时间为8周,主要观察指标:临床症状,空腹血糖(Fasting Blood Glucose,FBG),糖化血红蛋白(Glycosylated Hemoglobin,Hb A1c),β2微球蛋白(β2-microglobulin,β2-MG),尿白蛋白排泄率(Urinary Albumin Excretion Rate,UAER),纤溶酶原激活物抑制物(Plasminogen Activator Inhibitor 1,PAI-1)。结果:中西医结合组干预后临床症状、FBG、Hb A1c、β2-MG、PAI-1均有明显改善,中西医结合组总有效率80.00%,西药组总有效率57.5%,2组比较有统计学意义。结论:益气养阴、清热活血中药联合西药能减低糖尿病肾病Ⅲ期患者的SBP、DBP、FBG、Hb A1c、β2-MG、PAI-1,具有良好的安全性。     

浅谈岭南湿热咳嗽论治

<正>湿热咳嗽是感受湿热邪气,肺失宣肃引起的咳嗽,此类咳嗽其病程可缠绵数周至数月,常经用抗生素治疗无效。岭南地处南方,其特殊的气候环境,对湿热咳嗽的产生影响很大。笔者通过对岭南地区湿热咳嗽形成因素、辨证特点进行分析,进一步讨论岭南湿热咳嗽论治特点。1岭南湿热咳嗽的病因病机湿热咳嗽的发生,主要与外感湿邪和体质因素有关。岭南地处我国的南端,北以五岭为屏障,南濒临南海,属亚热带海洋性气候。又由于长年受偏东或偏南暖湿气流影响,气候炎热     

人工全膝关节置换术的手术护理体会

随着我国人民生活水平的提高,人工全膝关节置换术（totalknee arthroplasty,TKA）为越来越多的膝关节疼痛患者减轻了疼痛、改善膝关节的功能并提高了患者的生活质量。全膝关节置换术手术护理是手术成败与否的关键步骤,本文介绍我院62     

补肾活血法中药（糖络通）防治糖尿病大鼠早期视网膜病变的实验研究

目的：研究补肾活血法中药（糖络通）对糖尿病大鼠早期视网膜病变的防治作用及其作用机制。方法：随机将33只正常雄性Wistar大鼠分为正常对照组（N）11只,糖尿病对照组（D）11只,糖络通治疗组（DT）11只,连续给药8周后观察大鼠体重、空腹血糖、FPG、糖化血红蛋白（HbA1c）及大鼠视网膜RAGE mRNA的表达水平。并通过光镜电镜观察大鼠视网膜组织病理形态学的变化。结果：实验研究表明,糖络通可降低糖尿病大鼠视网膜RAGE mRNA的表达水平,组间比较有差异性（P＜0.01）;ALT, AST,Cr,BUN等安全性指标未出现异常,组间比较无统计学差异（P＞0.05）。结论：光镜、电镜观察表明糖络通对糖尿病大鼠的视网膜具有保护作用,能抑制神经节细胞及内外核层细胞的减少,减轻毛细血管扩张及视网膜组织的水肿。说明糖络通能够在一定程度上减缓DM大鼠视网膜的病理变化,对早期DR具有良好防治作用。为中医临床防治糖尿病微血管病变的研究提供理论依据。     

糖络通对防治糖尿病大鼠早期肾损害的实验研究

目的 研究糖络通对糖尿病大鼠早期肾脏损害的防治作用及其作用机制.方法 随机将33只正常雄性Wistar大鼠分为正常对照组(N)11只,糖尿病对照组(D)11只,糖络通治疗组(DT)11只,连续给药8周后观察大鼠体重、空腹血糖(FPG)、糖化血红蛋白(HbAlc)、24 h尿微量白蛋白(mAlb)、ALT、AST、肌酐(Cr)、尿素氮(BUN).并通过光镜电镜观察大鼠肾脏组织病变情况.结果 实验研究表明:糖络通在消除糖尿病大鼠蛋白尿方面有较好疗效,组间比较有差异性(P<0.01).ALT、AST、Cr、BUN未出现异常,组间比较无统计学差异(P>0.05).光镜电镜观察表明糖络通对糖尿病大鼠的肾脏具有保护作用,抑制或延缓肾小球系膜细胞和系膜基质弥漫性增生,肾小球足突规整,基底膜增厚减慢.结论 本研究证明糖络通对糖尿病大鼠早期即可保护其肾组织,减轻肾脏负担,延缓了糖尿病肾病的发展,为中医临床防治糖尿病微血管病变的研究提供理论依据.     

重用白术、草决明治疗帕金森病有良效

白术、草决明配伍且大剂量等量使用是广东省名中医沈英森教授的用药经验。笔者有幸随诊左右,亲睹其娴熟辨证施治于帕金森病患者,疗效显著。     

邓铁涛教授治疗失眠的经验

失眠是临床比较常见而又难治的病症 ,长时间的失眠会给患者带来很大的身心损害 ,甚至诱发或加重其他病症。现将邓老治疗失眠的经验介绍如下。1　痰阻为多 ,当化痰为先失眠的病因病机相当复杂 ,病因有七情所伤、饮食失节、劳倦过度等 ,但以情志所伤为最多见 ,病位则以心、肝、胆、脾、胃为主 ,总的病机是阳盛阴衰 ,阴阳失交 ,临床上可概括为虚、实两大类。虚者以心脾血虚、心胆气虚、心肾不交为主 ;实者以痰热、内火、瘀血为多 ,其中以痰阻为最多见。临床表现为患者难以入睡或彻夜难眠 ,伴胸闷 ,头晕 ,大便不爽 ,或恶心 ,平素喜酒或肥甘饮食 …     

Clinical Study of Dahuang Zhechong Pill (大黄■虫丸) in Treating Posthepatitis B Hepatic Fibrosis

Hepatic fibrosis is the only way for all kinds of chronic hepatic diseases to develop into liver cirrhosis. How to block and reverse hepatic fibrosis is the key issue for treatment of all kinds of chronic hepatic disease. After many years' arduous effort in treating hepatic fibrosis, no satisfactory results in western medical treatment have been obtained. Though hepatic fibrosis could be definitely re-