The Study on the Correlation Between Plasma Adiponectin Level and Coronary Heart Disease

Objectives To investigate the relationship between plasma adiponectin level and coronary heart disease （CHD）, and some established cardiovascular risk factors and to probe its probable pathogenesis which adiponectin results in CHD. Methods The levels of plasma adiponectin, fasting plasma insulin （FINS）, C-reactive protein （CRP） and P-selectin were measured by ELISA, plasma ET-1 was measured by radioimmunoassay （RIA） in 75 male patients with CHD and 30 healthy male people. Body mass index （BMI）, waist / hip ratio （WHR） and insulin resistance index （Homa-IR） were calculated respectively. Results （1）The plasma adiponectin levels in CHD group were lower compared with control group[（5.18±2.57）mg / L vs（8.94±2.59）mg / L, P〈 0.001 ], there was no significant difference of plasma adiponectin levels in CHD sub-groups （P 〉 0.05）.（2） Based on multinominal stepwise logistic regression analysis, adiponectin was one of significant and independent risk factors for CHD. （3） Multivariate liner stepwise regression analysis showed that adiponectin had significant correlation with BMI and TG, BMI and TG were independent factors influencing on plasma adiponectin levels. （4） Pearson correlation analysis indicated plasma adiponectin levels were inversely related to FINS levels , Homa-IR, CRP, P-selectin and ET-1. Conclusions （ 1 ）Plasma adiponectin levels are lower in CHD patients compared the control　subjects, there are no significant difference of plasma adiponectin levels in patients with SAP, UAP and AMI. （2） Plasma adiponectin levels are relative with CHD. Hypoadiponectinemia is an independent risk factor for CHD. （3）Established cardiovascular risk factors such as BMI and TG have an obvious influence on adiponectin. （4）The probable pathogenesis by which adiponectin involves in CHD is suggested that adiponectin relates to insulin resistance, inflammatory reaction and dysfunction of vessel endothelium.     

植物神经性癫痫误诊为冠心病8年一例

植物神经性癫痫误诊为冠心病８年一例李士玉，张金国，魏广和，朱红患者，男，５８岁。１９８３年开始出现无明显原因的头痛、头晕、心悸、胸闷、出汗、面色苍白，呈阵发性发作。发作时伴有一过性意识障碍，每天发作２～３次，每次３～５ｍｉｎ自行缓解，发作与终止均突然...     

多虚实并调方抗衰老作用的实验研究

将多虚实并调方设定5个药物浓度组，对二倍体细胞进行传代观察2个月，最后从中选定适宜的浓度进行再传代实验；将32只大鼠分四组，测定心肌脂褐素、血浆超氧化物歧化酶（SOD）、脂质过氧化物（MDA）及血清总胆固醇（TC）和甘油三酯（TG）；电镜观察其脑组织超微结构。结果证明，该方能明显增加入胚肺二倍体细胞的传代次数，改善老龄大鼠脑超微结构，降低脂褐色及血MDA、TC、TG，提高SOD，具有明显延缓衰老的作用。     

Ox-LDL和hs-CRP与冠心病患者冠脉病变的相关性

目的 探讨血氧化型低密度脂蛋白(Ox-LDL)、高敏C反应蛋白(hs-CRP)水平判断冠脉病变程度的价值.方法 将117例疑诊冠心病患者按选择性冠脉造影结果分为冠心病组78例和对照组39例(排除冠心病);采用ELISA法检测两组血浆Ox-LDL水平,免疫比浊法检测其hs-CRP水平.结果 冠心病组血浆Ox-LDL、hs-CRP水平均显著高于对照组(P均<0.01),稳定型心绞痛、不稳定型心绞痛、急性心肌梗死患者上述指标水平依次升高(P均<0.01);Gensini's分级≤10分、10～15分、15～20分和>20分者Ox-LDL水平依次升高(P均<0.01),但hs-CRP水平无显著差异.结论 Ox-LDL、hs-CRP与冠心病的发生、发展密切相关;Ox-LDL水平可用于评价冠脉严重程度.     

重组人组织型纤溶酶原激酶衍生物治疗下肢急性动脉栓塞的临床疗效观察

目的:观察重组人组织型纤溶酶原激酶衍生物(瑞通立)动脉灌注治疗急性下肢动脉栓塞的疗效及安全性。方法:在DSA下采用瑞通立动脉插管灌注治疗急性下肢动脉栓塞18例,并与尿激酶动脉置管溶栓治疗的37例比较治疗效果、血管开通率、下肢缺血改善时间及出血等并发症。结果:治疗组有效率94%,对照组86%,(P<0.05);治疗组血管开通率平均为92%,优于对照组75%(P<0.05)。治疗组缺血改善时间为(1.46±0.53)h,对照组为(4.35±0.25)h(P<0.05)。结论:瑞通立治疗急性下肢动脉栓塞是一种疗效肯定且安全的方法。     

食管型颈椎病1例

颈椎病又称颈椎综合征,是一种以退行性病理改变为基础的颈椎间盘突出、增生性颈椎炎的总称,是中老年人群的常见病。颈椎病分颈型、脊髓型、交感型、神经根型、椎动脉型、特殊型6型。食管型颈椎病临床少见。我科收治1例,报道如下。1临床资料患者男,68岁,发作性胸闷、心悸20余年,加重伴吞咽困难9d。既往"缺血性心肌病、高血压病、双膝关节炎"病史多年。门诊以"缺血性心肌病、心功能不全,食管占位"     

白细胞介素开发现状

白细胞介素(Interleukin,IL)是一类联系白细胞间相互作用的细胞因子。它们具有多种生物学功能,在机体免疫活性细胞的活化、增殖、成熟、分化以及免疫效应细胞功能发挥方面均起着重要作用,对多种恶性肿瘤、病毒感染,包括艾滋病等顽疾治疗效果明显。因此国内外对这类细胞因子的研究非常重视,开发很快,迄今已陆续发现13种IL,并     

西地那非治疗肺动脉高压临床观察（附20例报告）

目的评价西地那非治疗肺动脉高压的有效性和安全性。方法对肺动脉高压患者给予西地那非25 mg每日3次口服,观察治疗前和服药12周后的6 min步行距离、右室收缩压、平均肺动脉压、肺血管阻力等。结果治疗12周后,除病情恶化1例死亡外,其余患者与基线值比较,6 min步行距离（P〈0.01）增大,右心导管测定右室收缩压、平均肺动脉压和肺血管阻力均有下降（P〈0.01）。结论西地那非对肺动脉高压患者有肯定的长期疗效,且安全性较高。     

The role of mitochondrial autophagy in Doxorubicininduced cardiotoxicity

Background Doxorubicin is a widely used drug in all kinds of chemotherapy, but its application is limited by its cardiac toxicity to some extent. Most of scholars have studied doxorubicin induced myocardial injury and cardiomyocytes death, but the specific mechanism remains unclear. Autophagy is a metabolic pathway of degrading longevity protein and organelles by lysosome, especially selective autophagy which called mitochondrial autophagy exists in various cells. The normal range of mitochondrial autophagy helps to maintain the physiological function, otherwise, could lead to the development of disease. Recent studies have suggested that mitochondrial autophagy is involved in the progress of doxorubicin-induced cardiotoxicity. This article reviews the role of mitochondrial autophagy in doxorubicin-induced cardiotoxicity, and how mitochondrial autophagy is involved in the occurrence and development of the progress, in order to provide a theoretical basis of prevention and treatment.     

红霉素高产菌株的选育

以红霉素链霉菌0－11－26为出发菌株，经LiCl和紫外线复合诱变处理，再用含有4种不同结构类似物的培养基定向筛选，获得4株突变株，其中M－03－59摇瓶效价6876u/ml，比起始菌株（5328u/ml）提高29.1%，在10t发酵罐上连续6批验证，平均发酵效价7016u/ml，比原生产水平（5652u/ml）提高24.1%，并且质检全部合格，对生产实际具有重要意义。