微创清除颅内血肿前CT导引下定位在基层医院的应用价值

颅内血肿是神经科常见的危急重症 ,病死率和致残率均较高。 CT导引下微创清除颅内血肿作为一种操作简便 ,定位准确 ,损伤小 ,在较短时间内就可清除大部分血肿 ,以达到迅速减压作用的治疗方法 ,则大大降低了颅内血肿患者的病死率和致残率。 2 0 0 1年 10月～ 2 0 0 2年 12月我院     

柔肝冲剂抗肝纤维化的临床研究

为观察柔肝冲剂抗肝纤维化的作用,62例慢性乙肝患者以柔肝冲剂(黄芪、丹参、郁金等组成)治疗6个月.结果症状与体征有较大的改善;血清肝功能指标ALT、AST、GGT、SB下降非常显著(P＜0.01),AKP、G也有明显下降(P＜0.05);B超显示,肝脏大小、门静脉、脾静脉、脾厚等指标均有一定程度的改善;血清HA、CⅣ、PⅢNP、AGA与肝纤维化呈正相关关系,而LN、APoAI、TRF与肝纤维化呈负相关关系.病毒学观察显示可能有一定抑制病毒复制的作用;病理观察结果显示有一定的抗炎、抗肝纤维化作用.表明柔肝冲剂具有较明显的抗肝纤维化的作用.     

茵陈蒿汤分煎液与合煎液中大黄酚含量的测定

目的 研究单味中药精制颗粒剂在临床应用的药效物质基础。方法 采用Hypersil C18,甲醇-0．1％磷酸水溶液(85：15)作流动相,检到波长254nm。结果 大黄酚峰能与其它峰完全分离,分煎液大黄酚平均回收率99．41％,RSD＝2．27％,合煎液大黄酚平均回收率101．01％,RSD＝0．45％。结论 分煎液大黄酚含量高于合煎液。     

经尿道膀胱肿瘤电气化术治疗膀胱肿瘤的研究

目的　观察经尿道膀胱肿瘤电气化术 (TVBt)治疗浅表性膀胱肿瘤的疗效。方法　对15 6例浅表性膀胱肿瘤患者行TVBt,其中 17例并发良性前列腺增生 (BPH)者同时行经尿道前列腺电气化术 (TVP)。结果　TVBt平均手术时间为 2 7min ,TVBt加TVP为 90min。全组未发生大出血及膀胱穿孔。术后平均留置尿管 4d。获得随访 6～ 4 0个月的 15 1例患者中复发 70例。结论　TVBt具有操作简单、出血少、恢复快等优点。     

肺栓塞的影像诊断

目的：提高胸部X线平片、CT对肺栓塞诊断的认识。方法：对26例肺栓塞的影像学表现进行回顾性分析。结果：胸部X线平片中11例肺血管纹理改变为肺少血“缺血区”,6例表现多发小片斑片影,5例肺浸润或肺不张影,5例胸部X线平片无阳性表现。而CT阳性率为100％。结论：两者各具优缺点,两者结合,更有利于肺栓塞的诊断和治疗。     

人股动脉血管的径向拉伸性能

OBJECTIVE： To summarize the development of electroacupuncture stimulation in the treatment of stroke-induced limb spasm, to provide research possibilities or clinical development, and to clarify the mechanism and therapeutic effects of electroacupuncture stimulation. DATA SOURCES： Articles relating to therapeutic effects of electroacupuncture stimulation on treatment of stroke-induced limb spasm, as well as clinical studies （which are not limited to age, sex and race）, were retrieved from the China Journal Fulltext Database from January 2000 to December 2007. The key words were stroke, apoplexy, spasm, and electroacupuncture in Chinese. Other articles were obtained from specific journals or books. STUDY SELECTION： Data were first selected by title and abstract. Clinical and rehabilitative studies relating to the effects of electroacupuncture and acupuncture on the treatment of stroke-induced limb spasm were included. Clinical studies related to the rehabilitative treatment of limb spasm were excluded, unless the effects of electroacupuncture stimulation were recorded. DATA EXTRACTION： A total of 338 references were collected; however, 295 of these were excluded. Therefore, 43 articles were analyzed, comprising 40 in Chinese and 3 in English. DATA SYNTHESIS： At present, acupuncture is widely used at home to treat stroke-induced limb spasm; however, acupuncture at different acupoints might cause different clinical effects. Electroacupuncture, which is characterized by analgesia and relief of spasm, can preclude inflammatory edema, improve blood circulation and blood viscosity, inhibit platelet aggregation and adherence, relieve formation of atheromatous plaque in tunica intima of artery, and resist cerebral anoxia, so as to relieve stroke-induced limb spasm. Meanwhile, electroacupuncture combined with rehabilitation can effectively decrease the degree of spasm and improve motor function. CONCLUSION： Acupuncture and moxibustion therapy are superior in the rehabilitative treatment of stroke-induced li     

急性脑梗死早期血中miRNAs水平与脑侧支循环建立的关系

目的探讨急性脑梗死早期外周血清中miRNAs水平与侧支循环建立的关系及临床意义。方法选择2014年1月-2015年11月在我院住院的急性脑梗死患者,根据其脑侧支循环状况,分为侧支循环良好组(42例)与不良组(28例),另设31例健康体检者为对照。比较各组间一般临床资料及梗死早期血清中一组miRNAs的分子变化,并进一步用Logistic回归分析miRNAs水平与梗死患者侧支循环建立的关系。结果血清中抑制血管新生的MIR-15b、MIR-92a及促血管新生的MIR-126、MIR-132和MIR-210水平在侧支循环良好、不良组及对照组间存在差异表达,部分特异性miRNAs分子组间比较有显著性差异(P0.05,P0.01);Logistic回归显示,这些抑制或促血管新生的miRNAs,特别是促血管新生的MIR-126、MIR-132和MIR-210是急性脑梗死侧支循环建立好坏的影响因素。结论早期血清中一组特异性miRNAs分子可能作为一种预测急性脑梗死患者脑内侧支循环状况的便捷指标。     

静态尿道测压中气态测压导管的可重复性研究

回顾性纳入2021年5月至2022年3月于北京朝阳医院因下尿路症状(LUTS)行静态尿道压力测定(RUPP)的患者共53例(男9例, 女44例);年龄(55±16)(25～76)岁。纳入患者的LUTS初步临床诊断分类为:良性前列腺增生症9例, 间质性膀胱炎1例, 压力性尿失禁11例, 非梗阻性排尿困难32例。全套尿动力学检查由充盈期膀胱测压+压力-流率测定(PFS)+RUPP三部分组成, 所有尿动力检查均采用气态测压导管(ACC)及相应设备完成。所有患者均进行两次RUPP测定, 膀胱压(Pves)分别为(35.30±6.15)、(35.81±5.91)cmH2O(1 cmH2O=0.098 kPa);最大尿道压(Pura@max)分别为(141.91±36.53)、(145.02±38.85)cmH2O;功能尿道长度(FUL)分别为(41.70±16.34)、(42.55±16.40)mm;最大尿道闭合压(MUCP)分别为(106.57±36.44)、(109.41±39.27)cmH2O, 两次RUPP数据差异均无统计学意义(均P>0.05)。ACC所得RUPP测定数据的可重复...     

老年骨质疏松症合并肌少症患者营养状态及血清生物化学指标的变化

目的研究老年骨质疏松症(OP)合并肌少症患者营养状态和血清生物化学指标的变化及两者之间的关系。 方法选取老年OP合并肌少症患者102例为观察组,同期健康体检者100例为对照组。根据微型营养评价(MNA)量表评估营养状态,按营养状态结果将其分亚组。检测并比较各组血清生物化学指标。另采用Pearson积差系数分析MNA评分和生物化学指标的相关性。 结果观察组体质指数、基础代谢率、腰椎L2~4骨密度、上臂肌围、MNA评分、血红蛋白、白蛋白、前白蛋白、甘油三酯和总胆固醇水平均低于对照组(P＜0.05)。观察组血清磷高于对照组(P＜0.05)。观察组血清钙、维生素D3、骨碱性磷酸酶(BALP)及Ⅰ型胶原交联C末端肽(ICTP)水平均低于对照组,且随营养状态改善呈明显上升趋势(P＜0.05)。MNA评分与血清钙、维生素D3、BALP和ICTP呈明显正相关(P＜0.05)。 结论老年OP合并肌少症患者营养状态与血清生物化学指标存在明显相关性,提升患者营养状态可能对控制病情进展和改善预后具有积极作用。     

一种新的HBeAg阴性慢性乙型肝炎病毒变异机制

Objective To investigate mutation patterns in core promoter(CP)region of hepatitis B virus(HBV).Methods HBV DNA was extracted from sera of patients with chronic HBV infection.The CP sequence was amplified by polymerase chain reaction(PCR)and cloned into pMD19 T vector.The positive clones were then sequenced.The sequences were compared with known HBV genome in GenBank to identify the mutation sites and patterns of patients with chronic HBV infection.Results There were 74 clones from 21 patients with chronic HBV infection which were sequenced.The sequence comparisons showed that there was a 234-nucleotide deletion in CP region of HBV genome in 54 clones and a 245-nucleotide deletion in one clone.These deletion regions included CP,HBeAg initiation codon and direct repeat sequence(DR)Ⅰ regions,which named CP deletion(CPD).A1585T replacement mutation was also found in HBV strain with CPD,which indicated that there was linkage between these two mutations.Conclusions A novel mechanism of HBeAg negative chronic hepatitis B is observed,which includes deletions of CP and HBeAg initiation codon.Meanwhile,a simple and useful PCR method is developed to detect CPD.