南四湖区渔民发汞含量的调查

长时间食用被水体污染的生物,会造成机体生理、生化功能的改变。我们从1985年开始,对南四湖湖区渔民进行了发汞含量的调查,以评价人体对汞的蓄积水平。     

《中国血栓研究会》(筹)第三次常务理事会会议纪要

会议于1994年5月2日～5月4日在杭州华北饭店召开,会上听取了1993年主要工作汇报并讨论了1994年工作计划。一致同意:需继续发展会员和进一步完善组织,因血栓性疾病涉及临床各科,要发展相关学科从事血栓防治和研究(如     

中国颚口线虫(Gnathostoma)的研究 1.乌鳢(Ophicephalus argus)体内颚口线虫幼虫的调查研究

笔者于1989年10月25日～11月1日在上海市就九江、南昌、上海青浦、上海淀山湖、上海南汇、上海昆山、镇江和南京八个地区乌鳢共80.35公斤(120条)。进行颚口线虫幼虫的     

Synthesis of a new hydroxyethylene dipeptide isostere Phe ψ[CH2CH(OH)]Phe as HIV-1 protease inhibitor

A new type of pseudodipeptide isostere exampled by Phe ψ[CH2CH(OH)]Phe was synthesized from phenylalanine. The H]V protease inhibitory activity (IC50) of Noa-His-Pheψ[CH2CH(OH)]Phe-Ile-Amp was 0. 8 pmol·L-1.     

愈肾汤治疗小儿急性肾炎

笔者自1985～1990年以来,应用愈肾汤治疗小儿急性肾炎100例,结果:痊愈(症状消失,小便化验正常,随访1年无复发)64例,好转(症状改善,小便化验有少量红、白细胞)28例,无效8例。总有效率92%。     

Effects of Volatile Anesthetics on Glutamate Transporter, Excitatory Amino Acid Transporter Type 3: The Role of Protein Kinase C

Background: Glutamate transporters play an important role in maintaining extracellular glutamate homeostasis. The authors studied the effects of volatile anesthetics on one type of glutamate transporters, excitatory amino acid transporter type 3 (EAAT3), and the role of protein kinase C in mediating these effects.

Methods: Excitatory amino acid transporter type 3 was expressed in Xenopus oocytes by injection of EAAT3 mRNA. Using two-electrode voltage clamp, membrane currents were recorded before, during, and after application of l-glutamate. Responses were quantified by integrating the current trace and are reported as microcoulombs. Data are mean +/- SEM.

Results: l-Glutamate-induced responses were increased gradually with the increased concentrations of isoflurane, a volatile anesthetic. At 0.52 and 0.70 mm isoflurane, the inward current was significantly increased compared with control. Isoflurane (0.70 mm) significantly increased Vmax (maximum velocity) (3.6 +/- 0.4 to 5.1 +/- 0.4 [mu]C;P < 0.05) but not Km (Michoelis-Menten Constant) (55.4 +/- 17.0 vs. 61.7 +/- 13.6 [mu]m;P > 0.05) of EAAT3 for glutamate compared with control. Treatment of the oocytes with phorbol-12-myrisate-13-acetate, a protein kinase C activator, caused a significant increase in transporter current (1.7 +/- 0.2 to 2.5 +/- 0.2 [mu]C;P < 0.05). Responses in the presence of the combination of phorbol-12-myrisate-13-acetate and volatile anesthetics (isoflurane, halothane, or sevoflurane) were not greater than those when volatile anesthetic was present alone. Oocytes pretreated with any of the three protein kinase C inhibitors alone (chelerythrine, staurosporine, or calphostin C) did not affect basal transporter current. Although chelerythrine did not change the anesthetic effects on the activity of EAAT3, staurosporine or calphostin C abolished the anesthetic-induced increase of EAAT3 activity.     

Oxygenation of Liver Transplants as a Predictor of Success

ＯｘｙｇｅｎａｔｉｏｎｏｆＬｉｖｅｒＴｒａｎｓｐｌａｎｔｓａｓａＰｒｅｄｉｃｔｏｒｏｆＳｕｃｃｅｓｓＹＥＱｉｆａ（ＤｅｐａｒｔｍｅｎｔｏｆＳｕｒｇｅｒｙ，ＴｏｎｇｊｉＨｏｓｐｉｔａｌ，ＴｏｎｇｊｉＭｅｄｉｃａｌＵｎｉｖｅｒｓｉｔｙ，Ｗｕｈａｎ４３００...     

大剂量鲁米那钠加安定静脉滴入治疗新生儿破伤风

近年来新生儿破伤风有增加趋势,死亡率高,我院子1985年起,试用大剂量鲁米那钠加安定静脉滴入,治疗住院病儿52例,疗效满意,现报告如下: 临床资料治疗组52例,男36例,女16例,平均发病日龄9.19天。对照组123例,男91例,女32例,平均发病日龄9.75天。诊断标准参照教科书。痉挛强度用计分法:单纯牙关紧闭为1分,牙关紧闭+角弓反张+刺激性痉挛为2分,频繁自发性痉挛为3分,持久而严重的自发性痉挛+紫绀或呼吸暂停为4分。     

FDA审查Pfizer改变Norvasc标签的要求

美国FDA的心血管肾脏药物咨询委员会将在4月5日审查Pfizer公司请求修改Norvasc（amlodipine besylate，氨氯地平）（Ⅰ）的商标资料，其中包括具有里程碑意义的2002年ALLHAT研究中减少冠心病发作危险的结果。这项降压降脂预防心脏病发作试验共有42000多名高危的高血压病人参加。