分侧肾静脉肾素测定确诊肾血管性高血压1例报告

患者,男,16岁,于1988年2月23日以头痛、呕吐1个月,右眼视力模糊1O天为主诉入本院神经科诊治。做过脑血管造影和颅脑CT等没有明确诊断。按“脑蛛网膜炎治疗”病情有好     

高原人睾丸酮,雌二醇水平与年龄和血红蛋白相关性研究

本资料研究高原地区（３２００ｍ）３７５例正常人（１５－８５岁）的血浆睾酮（Ｔ）、雌二醇（Ｅ２）浓度与年龄和血红蛋白（Ｈｂ）等之间的相互关系，结果：（１男性Ｔ值在６０岁前高于平原值（Ｐ〈０．０５），在６０岁后，Ｔ随龄增加而下降，Ｅ２随龄增而上升。Ｈｂ和睾丸体积（Ｖ）在５０岁后，逐渐下降或减少，Ｈｂ与Ｔ之间呈正相关（ｒ＝０．２０２，Ｐ〈０．０５）；Ｔ／Ｅ２幽会在男性中随龄增而下降，在女性中则上升。提示     

平平淡淡度春秋

人老了,是自然规律;退休了,是国家政策规定,谁也抗拒不了。我是1980年离开工作岗位,加入到银发队伍的,转眼间二十多年矣。回首往事,觉得二十多年来,虽然过得平平淡淡,却也坦坦荡荡,自由自在,身心舒畅。退休后没有工作的劳累,身心轻松多了。有人说我,退休了该享福了;也有人说,参加工作早,什么“长“也没混上,退休后是普通老百姓……言外之意是有点吃亏。我并不这样想,我家祖祖辈辈务农,出了我这个有文化的人,又有令人羡慕的工作,当不当官又怎样呢?官位在人生大河中只是一把椅子,坐也好,不坐也罢,何必为它朝思暮想,伤心劳神?人生在世,诱惑多多…     

糖尿病酮症酸中毒十例治疗体会

近年来,糖尿病发病率明显升高,糖尿病酮症酸中毒(DKA)的病人随之增多,我院近3a来收治DKA共10例,现报告如下.     

低蛋白饮食对环孢素A肾病大鼠肾间质纤维化的作用

Objective To investigate whether low-protein diet has protective effect on the progression of renal interstitial fibrosis in rats with cyclosporine A (CsA)-induced nephropathy. Methods Eighteen male Sprague-Dawley rats were randomly divided into three groups (6 rats in each group). The rats in control group (C group) received common diet; in model group (M group) low-salt diet; in intervention group (Ⅰ group) low-salt and low-protein diet. After diet adaptation period of one week, the rats in C group received subcutaneous injection of olive oil 1 mg/kg daily for 5 weeks, while M group and Ⅰ group subcutaneous injection of CsA (diluted into 25 g/L with olive oil) 1 ml/kg for 5 weeks. All the rats were sacrificed at the end of the 5th week. The food-intake and body weight were measured daily. The creatinine clearance (Ccr) was examined before rats were sacrificed. The semi-quantitative pathological analysis on kidney sections was performed. The mRNA and protein expression of transforming growth factor-β1 (TGF-βI) and type Ⅰ collagen (Col Ⅰ) in kidney tissue was determined with real time PCR and immunohistochemical staining, respectively. Results The food-intake and body weight of rats in M and I groups were significantly lower than those in C group (P<0.05). Compared with C group, the Ccr levels in M and Ⅰ groups were significantly reduced [(0.65±0.15) ml/min, (0.40+0.13) ml/min vs (1.55±0.29) ml/min, P<0.05], the relative fibrosis areas of kidney interstitium in M and I groups were significantly increased (3.60%±0.46%, 3.26%±0.75% vs 0.44%±0.24%, P<0.05), the mRNA and protein expression of TGF-β1 in M and I group was significantly up-regulated (by 2.6 and 3.1 times in mRNA and by 1.5 and 1.6 times in protein, respectively, P<0.05), and the mRNA and protein expression of Col Ⅰ in M and I groups was also significantly up-regulated (by 3.0 and 3.5 times in mRNA and by 2.3 and 2.1 times in protein, respectively, P<0.05). There were no significant differences between M and I groups in every parameters above-mentioned except the rat body weight and Ccr. Both the body weight and Ccr in Ⅰ group were significantly lower than those in M group (P<0.05). Compared with C group, the urine osmotic pressure in M group and in I group were deceased (for M group, P>0.05; for I group, P<0.05). Compared with C group, the serum cholesterol levels in M and I groups were significantly increased (P<0.05), and the serum phosphorus level in I group was significantly decreased (P<0.05). The levels of serum albumin and serum calcium of all three groups had no statistical differences (P>0.05). Conclusion Low-protein diet has no renoprutective effects on the rat model of cyclosporin A nephropathy, on the contrary, may induce body weight loss.     

高果糖诱导IR大鼠模型血清脂质代谢的改变及意义

目的: 评估高果糖膳食对机体胰岛素敏感性及血清脂质代谢的影响及意义.方法:以高果糖膳食(果糖占总热量34.5%)诱导并经钳夹技术证实建立胰岛素抵抗(IR)大鼠模型,生化比色法测定血清游离脂肪酸(FFA),生化酶法测定血清甘油三酯(TG)及总胆固醇(TC).结果:高果糖膳食喂养4周后,实验组大鼠葡萄糖输注率由(11.5±0.6)mg/kg·min-1下降至(6.6±0.4)mg/kg·min-1(P<0.01);血清FFA由(0.45±0.09)mmol/L增至(0.78±0.19)mmol/L(P<0.01);TG由(0.54±0.10)mmol/L增至(0.96±0.22)mmol/L(P<0.01);TC由(1.96±0.32)mmol/L增至(2.42±0.21)mmol/L(P<0.01).结论:高果糖膳食可导致机体严重IR,是建立IR大鼠模型的有效手段;该模型同时伴有血清脂代谢各相关指标的明显异常,血脂的变化既是IR的结果,也是IR向纵深发展的原因和必要条件.     

医院感染统计监测系统的探讨

医院感染统计监测系统是医院现代化管理的重要手段 ,也是医院感染管理工作的基本方法。通过医院感染统计监测系统工作 ,为医院感染管理提供大量数据 ,研究医院感染的现状及可能导致医院感染的危险因素 ,预测医院感染的流行趋势 ,评估医院感染管理工作质量 ,为制订预防和控制医院感染的决策和措施提供科学依据。现就医院感染统计监测系统的建立、系统配置、指标体系和应用中的注意事项等探讨如下。1 医院感染统计监测系统的建立( 1)医院感染统计监测系统的作用　医院感染统计监测系统是把医学统计学的原理与方法应用于医院感染状况及感染危险…     

川芎嗪对弥漫性轴索损伤影像学变化及预后的影响

目的：探讨川芎嗪对弥漫性轴索损伤（DAI）的治疗作用。方法：42例DAI患者随机分为两组，治疗组除常规治疗加用川芎嗪，对照组仅常规治疗。结果：两组在伤后影像学及预后方面均有显著性差异。结论：伤后早期应用川芎嗪能明显促进挫伤及出血灶的吸收，改善DAI的预后。     

活得简单一点

采访一位百岁寿星,问及长寿秘诀时,老人以6字作答:“活得简单一点。”见我大惑不解的样子,他随后举了两个实例加以佐证: 老人80岁那年,他惟一的儿子撒手尘寰。家人怕老人经不住老来丧子的打击,日夜恭候左右,说着宽慰的话。老人一捋须髯说,人死不能复生,我会善待自己,好好活下去的。“这就是活得简单一点,不该苛求的事不去想,不去求。”老人如是诠释。