分化型甲状腺癌手术266例分析

分化型甲状腺癌是最常见的甲状腺恶性肿瘤,约占全身恶性肿瘤的1％。分化型甲状腺癌主要包括乳头状癌和滤泡状癌,发病率占甲状腺癌的90％。除髓样癌外,绝大多数分化型甲状腺癌起源于滤泡上皮细胞。本文通过分析266例分化型甲状腺癌患者的手术治疗的资料,总结分化型甲状腺癌的临床治疗经验。现报告如下。     

自发性血气胸31例外科治疗分析

我们1999年2月至2009年12月共收治自发性血气胸患者31例,采用胸腔闭式引流和开胸手术进行治疗,效果满意,报道如下. 临床资料     

乌司他丁抗腹部手术侵袭的临床观察

手术侵袭、机体发生应激反应，多种炎症因子被激活并相互作用。发生一系列复杂的病理过程，引起急性全身炎症性反应。病人抵抗手术创伤的能力是提高手术成功率，减少手术术后并发症的一个重要问题，现将我院应用乌司他丁(UTI)抗手术侵袭及预防组织损伤的作用的观察结果总结报告如下。     

Cytodext-3微载体/藻酸钠水凝胶作为可注射性支架构建组织工程软骨的可行性

BACKGROUND: Alginate hydrogel and microcarrier both can be used as injectable scaffolds, but their shortcomings such as poor mechanical property and poor plasticity remain unresolved. OBJIECTIVE: To explore the feasibility of constructing an injectable tissue-engineered cartilage with cytodex-3 microcarrier/alginate hydrogel composite. METHODS: Injectable cytodex-3 microcarrier/alginate hydrogel composite scaffold and injectable alginate hydrogel scaffold were established, and the mechanical properties of the two scaffolds were detected. Chondrocytes-seeded cytodex-3 microcarrier was obtained after incubated in the bioreactor, and then composited with alginate hydrogel as experimental group; chondrocytes were co-cultured with alginate hydrogel as control group. Subsequently, cell viability and ability of DNA and glycosaminoglycan synthesis were detected. RESULTS AND CONCLUSION: The Young’s modulus of the experimental group was significantly higher than that of the control group (P < 0.05). And in the control group, chondrocytes were in a round shape and evenly distributed in the alginate hydrogel; in the experimental group, chondrocytes adhered on the scaffold surface and evenly distributed in the scaffold. After 1 day of culture, both viable and numerous dead chondrocytes could be found in both two scaffolds; and after 14-day culture, there were no dead chondrocytes in both two scaffolds, abundant proliferating chondrocytes maintained a high cell viability, and the number of chondrocytes in the experimental group was significantly higer than that of the control group. What’s more, the contents of DNA and glycosaminoglycans were in a rise with time in both two groups, which were significantly higher in the experimental group than the control group (P < 0.05). These results suggest that the cytodex-3 microcarrier/alginate hydrogel composite is a promising injectable scaffold in cartilage tissue engineering.     

肝外伤的非手术治疗

为探讨肝外伤非手术治疗的临床意义及适应症 ,对 43例非手术治疗病例的临床资料进行了分析。结果显示 ,肝外伤行非手术治疗应在严格的监测及密切的观察下正确选择适应症 ,采取积极有效的治疗措施     

钠离子牛磺胆酸共转运多肽缺陷病及其对母胎影响的研究进展

钠离子牛磺胆酸共转运多肽（sodium-taurocholate cotransporting polypeptide,NTCP）缺陷病是一种溶质载体家族10成员1(solute carrier family 10 member 1,SLC10A1)双等位基因突变引起的胆汁酸代谢障碍性疾病,分布具有区域和种族差异,其中SLC10A1 c.800C>T (p.Ser267Phe)是我国的高频突变。NTCP缺陷病患儿主要表现为病理性黄疸,少部分有生长、运动和神经系统发育迟缓的表现,成年患者临床症状和体征不明显,生化检查提示血清总胆汁酸水平升高、部分伴有转氨酶和25-羟维生素D3水平降低。NTCP缺陷病性高胆汁酸血症需与乙型肝炎病毒感染、丁型肝炎病毒感染、自身免疫性肝炎及妊娠期肝内胆汁淤积症等鉴别,妊娠合并NTCP缺陷病性高胆汁酸血症对母胎的影响迄今少有相关报道。综述NTCP缺陷病的分子遗传机制、临床表现、实验室检查、诊断、治疗及其对母胎的影响,为该病患者的明确诊断和正确干预提供依据。     

高血压脑出血手术治疗的选择(附35例分析)

我院自1991年5月至1996年12月对35例高血压脑出血患者施行外科治疗，获得较满意效果，现报告如下。l临床资料（l）一般资料：35例中，男28例，女7例。年龄46～72岁，平均年龄54岁。（2）临床表现：术前深昏迷6例，中度昏迷15例，浅昏迷10例，增俄状态4例；双侧瞳孔散大8例，不对称一侧散大14例，其余对称无散大；四肢肌力0级6例，29例有一侧肢体不同程度瘫痪；29例原有明显的高血压病史。门）血肿部位和大小：脑皮质下白质出血10例，壳核出血19例，丘脑出血5例（破入脑室2例），小脑出血1例。均经CT扫描及术中证实。血肿大小根据多田氏公式…     

尼美舒利治疗脾切除术后发热48例

目的 观察尼美舒利治疗脾切除术后发热的疗效. 方法 选择脾切除术后发热的患者48例,分为对照组和治疗组. 对照组20例,服用吲哚美辛25 mg,tid, 治疗组28例,服用尼美舒利100 mg,bid. 观察治疗后24,48 h的体温变化情况,并对治疗的依从性和不良反应进行评估. 结果 治疗组用药后24,48 h,总有效率分别为78.6%,96.4%;对照组用药后24,48 h,总有效率分别为50.0%,75.0%;两组治疗的依从性差异有显著性（P＜0.05）. 治疗组出现恶心1例,对照组出现恶心、呕吐等消化道不良反应6例. 结论 尼美舒利治疗脾切除术后发热高效,安全,不良反应少,值得推广应用.