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31.
Irfan Sahin Ertugrul Okuyan Adnan Kaya Ilhan Ilker Avci Halil İbrahim Biter 《Scandinavian cardiovascular journal : SCJ》2014,48(5):278-283
Objectives. Vitamin D regulates calcium and bone homeostasis, and parathyroid hormone (PTH) secretion. Cross-sectional associations between lower vitamin D levels and cardiovascular diseases have been reported, but the relationship between vitamin D levels and collateral arteries in stable coronary artery disease (CAD) has not been reported before. Design. Two hundred and fourteen patients with above 95% stenosis in at least one epicardial coronary artery were consecutively recruited after coronary angiography (CAG) during the winter season. The coronary collateral circulation (CCC) was graded using Rentrop classification. Poor CCC group included patients with Rentrop Grade 0–1 CCC and control group included patients with Rentrop Grade 2–3 CCC. Vitamin D and PTH levels were measured on the day of CAG. Results. In the poor CCC group, vitamin D levels were lower (34 ± 25 pmol/L vs. 49 ± 33 pmol/L; p = 0.01) and the prevalence of vitamin D deficiency (< 37 pmol/L) was higher (67% vs. 43%; p = 0.01) compared to the controls. PTH levels, calcium, and phosphate levels were not significantly different between the groups. Female gender, lower HDL cholesterol, and lower vitamin D levels were independently correlated with poor CCC in the study population. Conclusion. Lower vitamin D levels may be associated with poor collateral development in patients with stable CAD. 相似文献
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Mehmet İlker Gökçe Parviz Hajıyev Evren Süer Yusuf Kibar Mesrur Selçuk Sılay Serhat Gürocak Hasan Serkan Doğan Hasan Cem Irkılata Tayfun Oktar Bülent Önal Erim Erdem Yüksel Cem Aygün Can Balcı Ahmet Rüknettin Arslan Cevdet Kaya Tarkan Soygür Şaban Sarıkaya Serdar Tekgül Berk Burgu 《The Journal of urology》2014
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G. Kocabay MD C.Y. Karabay A. Kalayci T. Akgun A. Guler V. Oduncu İ.H. Tanboga A. İzgi C. Kirma 《Herz》2014,39(4):522-527
Background
Contrast-induced neurotoxicity (CIN) is a very rare complication of coronary angiography. Clinical presentations include encephalopathy, seizures, cortical blindness, and focal neurological deficits. An inherent difficulty in understanding the natural history of the condition as well as its risk factors and prognosis is the rarity of its occurrence. To date, there are only case reports published on this complication.Patients and methods
This was a retrospective analysis of 9 patients with CIN (8 men, 1 woman; mean age, 64.6?±?7.8 years; range, 47–72 years) and coronary artery disease who were administered iopromide contrast agent.Results
In the last 3 years, we diagnosed 9 patients with CIN. Of these, 8 patients (89?%) had hypertension. The clinical presentations of the patients were different on admission: 6 patients had acute coronary syndrome and 3 patients had stable angina pectoris. One patient had history of previous contrast agent exposure. All patients underwent coronary angiography with a low-osmolar nonionic monomer contrast agent (iopromide; Ultravist®-300, Bayer Healthcare). The mean volume of contrast injected was 177?±?58 ml. The mean time between contrast agent administration and clinical symptoms was 100?±?71 min (range, 30–240 min). While in 5 of the patients (56?%) the clinical sign of CIN was confusion, 2 had ophthalmoplegia, 1 had cerebellar dysfunction, and 1 had monoplegia. In 8 of 9 patients (89?%), neurological symptoms resolved after giving supportive medication and hydration. Only 1 female patient, who had bilateral ophthalmoplegia, did not recover. Neurological recovery occurred at a mean time of 14.2?±?6.7 h (range, 8–30 h).Conclusion
CIN is a very rare condition. Advanced age, male gender, and hypertension are the greatest risk factors for CIN. Although the prognosis of CIN is benign, it can potentially cause permanent neurological deficits or death. We found that patients with ophthalmic involvement had a higher propensity for persistent deficit. On the basis of the current data, we propose 170 ml as the maximal recommended dose for coronary procedures. 相似文献37.
Adalet Meral Güneş Hale Ören Birol Baytan Şebnem Yılmaz Bengoa Melike Sezgin Evim Salih Gözmen Özlem Tüfekçi Tuba Hilkay Karapınar Gülersu İrken 《Annals of hematology》2014,93(10):1677-1684
Dramatic progress in the treatment of childhood acute lymphoblastic leukemia (ALL) has been achieved during the last two decades in Western countries, where the 5-year event-free survival (EFS) rate has risen from 30 to 85 %. However, similarly high cure rates have not always been achieved in all centers in developing countries due to limited sources. We evaluated the treatment results of the ALL-Berlin–Frankfurt–Münster (BFM) 95 protocol as used between 1995 and 2009 in the pediatric hematology departments of two university hospitals. A retrospective analysis of 343 children newly diagnosed with ALL (M/F 200/143, median age 6.8 years) was performed. The overall survival (OS) and EFS according to age, initial leukocyte count, immunophenotype, chemotherapy responses (on days 8, 15, and 33), and risk groups were analyzed by Kaplan–Meier survival analysis. Median follow-up time was 6.4 years. Complete remission was achieved in 97 % of children. Five-year EFS and OS were found to be 78.4 and 79.9 %, respectively. Children younger than 6 years old had significantly better EFS and OS (83.7 and 85.2 %) than children aged ≥6 years (71.4 and 72.8 %). Adolescents achieved 63 % EFS and 65 % OS. Patients who had initial leukocyte counts of <20?×?109/L had better EFS and OS (82.2 and 84.6 %) than children with higher initial leukocyte counts (72.6 and 72.6 %). EFS for B-cell precursor and T-cell ALL was 81.5 and 66.7 %, respectively. Children with a good response to prednisolone on day 8 (87 %) achieved significantly better EFS and OS (81.2 and 81.9 % vs. 55.3 and 60.5 %). Children whose bone marrow on day 15 was in complete remission had higher EFS and OS (83.7 and 86.6.1 % vs. 56.4 and 61.5 %). Children in the standard-risk and medium-risk groups obtained statistically significantly higher EFS (95.5 and 82.7 %) and OS (97.7 and 82.3 %) compared to the high-risk group (EFS 56.3 %, OS 63.4 %). The relapse rate was 14.8 %. The median relapse time from diagnosis was 23.2 months. Death occurred in 69 of 343 patients (20.1 %). The major causes of death were infection and relapse. None of the patients died of drug-related toxicity. The ALL-BFM 95 protocol was applied successfully in these two centers. In developing countries in which minimal residual disease cannot be monitored, this protocol can still be used with high survival rates. 相似文献
38.
Özdemir Zeynep Başak-Türkmen Neşe Ayhan İdris Çiftçi Osman Uysal Mehtap 《Pharmaceutical Chemistry Journal》2019,52(11):923-929
Pharmaceutical Chemistry Journal - In this study, seven new 3(2H)-pyridazinone derivatives expected to show cytotoxic activity in liver and colon cancer cell lines were synthesized. Their... 相似文献
39.
Türk İpek Cüzdan Nihan Çiftçi Volkan Arslan Didem Doğan Muharrem Cem Unal İlker 《Clinical rheumatology》2020,39(1):57-67
Clinical Rheumatology - The aim of this study was to evaluate the associations between malnutrition and the clinical features of the disease and depression in patients with systemic sclerosis... 相似文献
40.
Yayla Müçteba Enes İlgen Ufuk Okatan İlyas Ercan UsluYurteri Emine Torgutalp Murat Keleşoğlu Dinçer Ayşe Bahar Aydemir Gülöksüz Emine Gözde Sezer Serdar Turgay Tahsin Murat Kınıklı Gülay Ateş Aşkın 《Clinical rheumatology》2020,39(1):77-83
Clinical Rheumatology - Neutrophil-to-lymphocyte ratio (NLR), monocyte-to-lymphocyte ratio (MLR), mean platelet volume (MPV), and red cell distribution width (RDW) may potentially reflect... 相似文献