全文获取类型
收费全文 | 10082篇 |
免费 | 881篇 |
国内免费 | 12篇 |
专业分类
耳鼻咽喉 | 258篇 |
儿科学 | 554篇 |
妇产科学 | 316篇 |
基础医学 | 1085篇 |
口腔科学 | 650篇 |
临床医学 | 899篇 |
内科学 | 1879篇 |
皮肤病学 | 261篇 |
神经病学 | 811篇 |
特种医学 | 435篇 |
外国民族医学 | 2篇 |
外科学 | 2061篇 |
综合类 | 44篇 |
一般理论 | 3篇 |
预防医学 | 513篇 |
眼科学 | 243篇 |
药学 | 588篇 |
中国医学 | 14篇 |
肿瘤学 | 359篇 |
出版年
2023年 | 150篇 |
2022年 | 97篇 |
2021年 | 268篇 |
2020年 | 224篇 |
2019年 | 267篇 |
2018年 | 474篇 |
2017年 | 371篇 |
2016年 | 465篇 |
2015年 | 490篇 |
2014年 | 556篇 |
2013年 | 926篇 |
2012年 | 507篇 |
2011年 | 511篇 |
2010年 | 513篇 |
2009年 | 316篇 |
2008年 | 273篇 |
2007年 | 206篇 |
2006年 | 361篇 |
2005年 | 314篇 |
2004年 | 202篇 |
2003年 | 183篇 |
2002年 | 217篇 |
2001年 | 285篇 |
2000年 | 265篇 |
1999年 | 266篇 |
1998年 | 193篇 |
1997年 | 131篇 |
1996年 | 158篇 |
1995年 | 104篇 |
1994年 | 126篇 |
1993年 | 94篇 |
1992年 | 107篇 |
1991年 | 115篇 |
1990年 | 91篇 |
1989年 | 73篇 |
1988年 | 74篇 |
1987年 | 76篇 |
1986年 | 71篇 |
1985年 | 53篇 |
1984年 | 54篇 |
1983年 | 50篇 |
1982年 | 49篇 |
1981年 | 46篇 |
1980年 | 43篇 |
1979年 | 51篇 |
1978年 | 29篇 |
1977年 | 35篇 |
1976年 | 27篇 |
1973年 | 35篇 |
1967年 | 24篇 |
排序方式: 共有10000条查询结果,搜索用时 31 毫秒
991.
992.
Background: Inpatient aggression among female forensic psychiatric patients has been shown to be associated with self-harm, that is considered to be a historical risk factor for violence. Research on associations between previous or current self-harm and different types of inpatient aggression is missing.Aim: The aim of this register study was to investigate the prevalence of self-harm and the type of inpatient aggression among female forensic psychiatric inpatients, and to study whether the patients’ self-harm before and/or during forensic psychiatric care is a risk factor for inpatient aggression.Methods: Female forensic psychiatric patients (n?=?130) from a high security hospital were included.Results: The results showed that 88% of the female patients had self-harmed at least once during their life and 57% had been physically and/or verbally aggressive towards staff or other patients while in care at the hospital. Self-harm before admission to the current forensic psychiatric care or repeated self-harm were not significantly associated with inpatient aggression, whereas self-harm during care was significantly associated with physical and verbal aggression directed at staff.Conclusions: These results pointed towards self-harm being a dynamic risk factor rather than a historical risk factor for inpatient aggression among female forensic psychiatric patients. Whether self-harm is an individual risk factor or a part of the clinical risk factor ‘Symptom of major mental illness’ within the HCR-20V3 must be further explored among women. Thus, addressing self-harm committed by female patients during forensic psychiatric care seems to be important in risk assessments and the management of violence, especially in reducing violence against staff in high-security forensic psychiatric services. 相似文献
993.
994.
Imaging of Anterior Nucleus of Thalamus Using 1.5T MRI for Deep Brain Stimulation Targeting in Refractory Epilepsy 下载免费PDF全文
995.
R. Becher S. Öhl U. W. Schaefer E. Wendehorst F. Quiskamp H. K. Mahmoud F. Schüning C. G. Schmidt 《Annals of hematology》1984,48(4):247-250
Summary Clonal chromosomal evolution was observed in a 16-year-old boy suffering from Ph1-positive CML. An isodicentric Ph1 chromosome appeared 20 weeks after the initial diagnosis. At that time an allogeneic bone marrow transplantation was performed.Thereafter, during an observation period of more than 13 months, chromosome analyses showed neither the Ph1 chromosome nor the abnormal isodicentric variant. Close cytogenetic monitoring is suggested to reveal early unfavourable prognostic signs of the onset of blast crisis before it becomes evident in the bone marrow morphology. 相似文献
996.
Lentiviral vectors have turned out to be an efficient method for stable gene transfer in vitro and in vivo. Not only do fields of application include cell marking and tracing following transplantation in vivo, but also the stable delivery of biological active proteins for gene therapy. A variety of cells, however, need immediate transplantation after preparation, for example, to prevent cell death, differentiation or de-differentiation. Although these cells are usually washed several times following lentiviral transduction, there may be the risk of viral vector shuttle via transplanted cells resulting in undesired in vivo transduction of recipient cells. We investigated whether infectious lentiviral particles are transmitted via ex vivo lentivirally transduced cells. To this end, we explored potential viral shuttle via ex vivo lentivirally transduced cardiomyocytes in vitro and following transplantation into the brain and peripheral muscle. We demonstrate that, even after extensive washing, infectious viral vector particles can be detected in cell suspensions. Those lentiviral vector particles were able to transduce target cells in transwell experiments. Moreover, transmitted vector particles stably transduced resident cells of the recipient central nervous system and muscle in vivo. Our results of lentiviral vector shuttle via transduced cardiomyocytes are significant for both ex vivo gene therapy and for lentiviral cell tracing, in particular for investigation of stem cell differentiation in transplantation models and co-cultivation systems. 相似文献
997.
Paul Hengster Rolf Linke Clemens Decristoforo Johann Feichtinger Leo Fridrich Thomas Eberl Dietmar Öfner Georg Riccabona Raimund Margreiter 《Zeitschrift für die gesamte experimentelle Medizin einschliesslich experimenteller Chirurgie》1997,197(5):255-262
Fatty acids are promptly taken up, metabolised and eliminated by healthy cardiomyocytes. Cardiomyopathy, coronary heart disease and chronic rejection are known to be associated with an impaired fatty acid metabolism. It was the aim of this study to investigate fatty acid metabolism in a rat heart transplant model and to correlate scintigraphic findings with histological changes. After right-side nephrectomy of Lewis recipients Brown Norway cardiac allografts were anastomosed to the renal vessels. Animals were given no immunosuppression. The metabolism of carrier-free 17-123 jodo-heptadecanoic acid (123J-HDA) with a specific activity of >2×1017 Bq/ml was scintigraphically measured between days 1 and 11. An increase in the grade of rejection was observed over time. Fifty-six frames of 30 s duration each were recorded. For the region of interest (native heart, transplanted heart, left kidney) frames 10–56 were superimposed, time-activity curves generated and monoexponentially fitted. Furthermore, elimination half-life and intercepts were calculated. Following scintigraphic evaluation the animals were killed and graft as well as native hearts excised for histological examination. The uptake of the tracer identified severe grades of rejection. Elimination half-life of the tracer was twice as long from hearts with mild rejection and more than 14 times as long in severe rejection compared with no rejection. Elimination half-life and amplitude did not permit discrimination between grades 1, 2 and 3 a, but significantly decreased in groups 3 b and 4. This method therefore seems to be a valuable tool for the noninvasive detection of severe acute cardiac allograft rejection. Since fatty acid metabolism is clearly stress-dependent it remains to be seen whether this method allows detection of earlier rejection in loaded hearts. 相似文献
998.
Aggressive behavior is a basic form of human social interaction, yet little is known about its neural substrates. We used a laboratory task to investigate the neural correlates of reactive aggression using functional magnetic resonance imaging. The task is disguised as a reaction-time competition between the subject and two opponents and entitles the winner to punish the loser. It seeks to elicit aggression by provocation of the subject. As each single trial in this task is separated into a decision phase, during which the severity of the prospective punishment of the opponent is set, and an outcome phase, during which the actual punishment is applied or received, the paradigm enables us to analyze the neural events during each of these phases. Specific neural responses in areas related to negative affect, cognitive control and reward processing provide additional information about the cognitive, emotional and motivational processes underlying reactive aggressive behavior and afford us with the possibility to test and expand theories on aggression such as the General Aggression Model. 相似文献
999.
Prevalences of diabetes and impaired glucose regulation in a Danish population: the Inter99 study 总被引:16,自引:0,他引:16
OBJECTIVE: To determine the age- and sex-specific prevalence of impaired fasting glycemia, impaired glucose tolerance, screen-detected diabetes, and known diabetes in a Danish population aged 30-60 years and to examine the phenotype and the cardiovascular risk profile in individuals with impaired glucose regulation. RESEARCH DESIGN AND METHODS: In the Inter99 study, 13,016 inhabitants living in Copenhagen County were invited. All participants underwent anthropometric measurements, blood samples, and a 75-g standardized oral glucose tolerance test. RESULTS: The age-specific prevalences in men were as follows: impaired fasting glycemia: 1.4-16.3%; impaired glucose tolerance: 6.9-17.8%; screen-detected diabetes: 0.7-9.7%; and known diabetes: 0-5.8%. The corresponding figures in women were 0-5.1, 10.5-17.3, 0.6-6.3, and 0.5-9%. The prevalence of impaired glucose regulation increased with age. Among individuals with diabetes, 65.6% were previously undiagnosed; this proportion was highest in the youngest age-group (82% among 45-year-old men vs. 63% among 60-year-old men, and 70% among 45-year-old women vs. 52% among 60-year-old women). Mean BMI, waist, HbA(1c), systolic blood pressure, diastolic blood pressure, and total cholesterol were significantly higher (P < 0.0001) in the individuals with impaired glucose regulation compared with individuals with normal glucose tolerance. CONCLUSIONS: This study revealed that the prevalence of type 2 diabetes is high and that still two out of three individuals are undiagnosed, indicating a need for more attention to the disease in society. 相似文献
1000.