全文获取类型
收费全文 | 1979篇 |
免费 | 127篇 |
国内免费 | 11篇 |
专业分类
耳鼻咽喉 | 55篇 |
儿科学 | 107篇 |
妇产科学 | 96篇 |
基础医学 | 163篇 |
口腔科学 | 105篇 |
临床医学 | 232篇 |
内科学 | 418篇 |
皮肤病学 | 94篇 |
神经病学 | 115篇 |
特种医学 | 57篇 |
外科学 | 301篇 |
综合类 | 26篇 |
一般理论 | 1篇 |
预防医学 | 70篇 |
眼科学 | 104篇 |
药学 | 99篇 |
中国医学 | 3篇 |
肿瘤学 | 71篇 |
出版年
2024年 | 3篇 |
2023年 | 38篇 |
2022年 | 65篇 |
2021年 | 92篇 |
2020年 | 64篇 |
2019年 | 91篇 |
2018年 | 102篇 |
2017年 | 69篇 |
2016年 | 95篇 |
2015年 | 101篇 |
2014年 | 119篇 |
2013年 | 167篇 |
2012年 | 172篇 |
2011年 | 135篇 |
2010年 | 74篇 |
2009年 | 81篇 |
2008年 | 110篇 |
2007年 | 84篇 |
2006年 | 93篇 |
2005年 | 77篇 |
2004年 | 78篇 |
2003年 | 43篇 |
2002年 | 45篇 |
2001年 | 13篇 |
2000年 | 13篇 |
1999年 | 12篇 |
1998年 | 24篇 |
1997年 | 14篇 |
1996年 | 11篇 |
1995年 | 10篇 |
1994年 | 7篇 |
1993年 | 2篇 |
1992年 | 4篇 |
1991年 | 2篇 |
1990年 | 1篇 |
1988年 | 1篇 |
1985年 | 2篇 |
1984年 | 1篇 |
1983年 | 1篇 |
1979年 | 1篇 |
排序方式: 共有2117条查询结果,搜索用时 15 毫秒
1.
2.
Gülin Vural Mustafa Ünlü Tamer Atasever Izlem Özur Ayşegül Özdemir Nahide Gökçora 《European journal of nuclear medicine and molecular imaging》1997,24(3):312-315
Indium-111 octreotide and thallium-201 scintigraphic studies were compared in 21 patients (16 with palpable and five with non-palpable lesions) suspected of having breast malignancies on the basis of mammography. Early (15 min) and late (3 h)201Tl (111 MBq) and 4-h and 24-h111In-octreotide (111–148 MBq) static planar anterior images (matrix 256×256) were obtained on separate days. Images were evaluated both visually and quantitatively. Biopsy was performed following the imaging studies. Histopathology revealed 17 breast carcinomas (15 cases of invasive ductal carcinoma, one mucinous adenocarcinoma and one intraductal carcinoma) and four benign breast lesions (two fibroadenomas, one abscess and one case of fat necrosis). The means histopathologcial tumour size (mean largest diameter) was 3.38±1.9 cm.111In-octreotide detected 16 of the 17 breast cancers (94%) while201Tl detected 13 of them (76%). Both111In-octreotide and201Tl missed one nonpalpable carcinoma showing only an isolated cluster of microcalcifications on mammography. The smallest tumour size detected by both agents 1.5×1.5 cm. Of the four benign lesions, only the breast abscess revealed both201Tl and111In-octreotide uptake.111In-octreotide scan also showed tracer uptake in five of the six patients with histologically proven axillary metastases, while four of these six patients showed201Tl uptake. The tumour/background (T/B) ratios of late111In-octreotide and201Tl images were 1.71±0.38 and 1.46±0.30 respectively (P=0.039). In this preliminary study,111In-octreotide yielded more favourable results than201Tl in the detection of breast carcinomas. However, the diagnostic efficacy of111In-octreotide imaging needs to be investigated in larger patient series. 相似文献
3.
Sodium Hydroxide Chemical Matricectomy for the Treatment of Ingrown Toenails: Comparison of Three Different Application Periods 总被引:2,自引:1,他引:1
Kocyigit Pelin MD Bostanci Seher MD Özdemir Esin MD Gürgey Erbak MD 《Dermatologic surgery》2005,31(7):744-748
Objective Sodium hydroxide matricectomy is a successful method for the treatment of ingrown toenails. This study was designed to evaluate the optimal sodium hydroxide application period providing high success rates with minimal postoperative morbidity.
Materials and Methods Sixty-six patients with 225 ingrown nail edges were treated in three groups receiving 30-second, 1-minute, and 2-minute applications of sodium hydroxide. Each patient was reviewed postoperatively for pain, drainage, and tissue damage. The median long-term follow-up period was 14 months.
Results The success rate of the therapy was 70.9% in the first group, 92.7% in the second group, and 94.4% in the third group. In all groups, about half of the patients experienced minimal pain within 48 hours following the operation, but only in the third group, 20% of the patients had minimal pain, which continued about 1 week. Drainage and tissue damage were minimal or mild in all groups and disappeared within 3 weeks in the first and second groups but were prolonged to 6 weeks in the third group.
conclusion The success rate of 30-second application is significantly lower than 1-minute and 2-minute applications. Although the success rates of the latter two procedures are similar, the prolonged healing time is the disadvantage of the 2-minute application. We conclude that 1-minute application of 10% sodium hydroxide is simple, safe, and highly effective for the treatment of ingrown nails. 相似文献
Materials and Methods Sixty-six patients with 225 ingrown nail edges were treated in three groups receiving 30-second, 1-minute, and 2-minute applications of sodium hydroxide. Each patient was reviewed postoperatively for pain, drainage, and tissue damage. The median long-term follow-up period was 14 months.
Results The success rate of the therapy was 70.9% in the first group, 92.7% in the second group, and 94.4% in the third group. In all groups, about half of the patients experienced minimal pain within 48 hours following the operation, but only in the third group, 20% of the patients had minimal pain, which continued about 1 week. Drainage and tissue damage were minimal or mild in all groups and disappeared within 3 weeks in the first and second groups but were prolonged to 6 weeks in the third group.
conclusion The success rate of 30-second application is significantly lower than 1-minute and 2-minute applications. Although the success rates of the latter two procedures are similar, the prolonged healing time is the disadvantage of the 2-minute application. We conclude that 1-minute application of 10% sodium hydroxide is simple, safe, and highly effective for the treatment of ingrown nails. 相似文献
4.
Emine Sözeri Dietrich Feist Hans Ruder Karl Schärer 《Pediatric nephrology (Berlin, Germany)》1997,11(3):307-311
Renal lesions have repeatedly been described in Wilson’s disease (WD). We investigated the excretion of total protein, albumin,
low (LMW) and high molecular weight (HMW) proteins, N-acetyl-β-D-glucosaminidase (NAG), and calcium, as well as creatinine clearance, in 24-h urine samples of 41 patients with WD aged 6 – 37
(mean 17) years who had been treated for a period of 0 – 15 (mean 4.5) years with D-penicillamine (900 mg/day). The amount of all protein excreted was significantly increased compared with controls, 39% of
patients presenting with total proteinuria more than two standard deviations from the mean of controls. The changes in protein
excretion depended on the duration of treatment. LMW proteinuria was elevated almost exclusively in the first 2 years after
the start of treatment, indicating early tubular damage. This is supported by an initially high excretion of β2-microglobulin, NAG, and calcium. Increased excretion of HMW proteins, including albumin, persisted over longer periods, which
suggests glomerular injury in some patients, possibly related to the use of D-penicillamine. Creatinine clearance remained roughly within normal limits. We propose that renal function should regularly
be checked in patients with WD.
Received October 26, 1995; received in revised form August 27, 1996; accepted September 20, 1996 相似文献
5.
6.
Emine Cagnur Ulukus H Aydanur Kargi Banu Sis Banu Lebe Ilhan Oztop Atilla Akkoclu Ahmet Onen Aydin Sanli 《Applied immunohistochemistry & molecular morphology》2007,15(1):31-37
The role of survivin that regulates the biological behavior of non-small-cell lung carcinoma (NSCLC) is still controversial. We aimed to investigate survivin expression in NSCLC and to define any correlation with expressions of p53, bcl-2, bax, apoptotic index (AI), tumor cell proliferation, clinicopathologic variables, and overall survival. Tumors of 63 patients with NSCLC were examined for expressions of survivin, p53, bcl-2, bax, and Ki-67 by immunohistochemistry. AI was also evaluated. Results for each antibody were correlated with each other, and with clinicopathologic variables including age, sex, histologic subtype, TNM (T: primary tumor, N: regional lymph node metastasis, M: distant metastasis) stage, lymph node status, smoking history, and prognosis. Nuclear survivin expression was inversely correlated with p53 expression (P = 0.04, r = - 0.367), and tumor stage (P = 0.03, r = - 0.273), and positively correlated with tumor cell proliferation (P = 0.009, r = 0.329). Cytoplasmic survivin expression positively correlated with smoking history (P = 0.02, r = 0.282). Survivin/bax ratio was inversely correlated with AI (r: - 0.004). By Kaplan-Meier analysis, TNM stage (P < or = 0.001), lymph node metastasis (P = 0.04), and Ki-67 index (P < or = 0.001) were associated with survival, whereas survivin was not. In multivariate analysis, only TNM stage was an independent predictor. Although survivin and other apoptosis-related protein expressions fail to predict the clinical outcome, the present findings suggest that survivin is involved in tumor cell apoptosis and proliferation and may play a role in critical steps of cancer progression in NSCLC. 相似文献
7.
Interdigitating dendritic cell tumor with breast and cervical lymph-node involvement: a case report and review of the literature 总被引:3,自引:0,他引:3
Uluoğlu O Akyürek N Uner A Coşkun U Ozdemir A Gökçora N 《Virchows Archiv : an international journal of pathology》2005,446(5):546-554
Interdigitating dendritic cell tumor (IDCT) is an extremely rare malignancy. It occurs primarily in lymph nodes, but extranodal involvement has also been reported. A 38-year-old woman with IDCT with breast and cervical lymph-node involvement is reported in this paper. To our knowledge, this is the first case of IDCT originating from the breast. In the breast and lymph node, the tumor displayed diffuse sheets, fascicles and storiform growth pattern. It was composed of oval to spindle cells with pale to eosinophilic cytoplasm, ill-defined cell outlines, oval nuclei with vesicular chromatin and prominent eosinophilic nucleoli. Mitotic activity was three per ten high-power fields. The neoplastic cells were intermingled with small mature lymphocytes and plasma cells. Immunohistochemical studies showed that the tumor cells were strongly and diffusely positive for vimentin, CD68, S-100 protein, CD45/leukocyte common antigen and fascin and focally positive for lysozyme, alpha-1 antitrypsin and CD4. Ki-67 labeling index was 10%. The patient was treated with combined therapeutic approaches, including surgery, radiotherapy and chemotherapy. IDCT has the potential for an aggressive clinical course. However, 32 months after the initial diagnosis, the patient is still alive and being followed with a stable tumor burden. 相似文献
8.
Mahmut C. Ergoren Gokce Akan Ender Volkan Emine Kandemis Emine U. Evren Hakan Evren Eliz Volkan Gulten Tuncel Kaya Suer Tamer Sanlidag 《Journal of medical virology》2023,95(1):e28309
There is a significant body of evidence showing that efficient vaccination schemes against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is helping control the coronavirus disease 2019 (COVID-19) pandemic. However, this goal cannot be achieved without real world data highlighting the impact of vaccines against viral spread. In this study, we have aimed at differentially investigating the impact of COVID-19 vaccines (CoronaVac, Pfizer/BioNTech, Astra/Zeneca Oxford, Janssen) used in North Cyprus in limiting the viral load of Delta and Omicron variants of SARS-COV-2. We have utilized real-time quantitative polymerase chain reaction cycle threshold values (Ct values) as a proxy of viral load of the two SARS-CoV-2 variants. Our results indicate that the administration of at least two doses of the messenger RNA-based Pfizer/BioNTech vaccine leads to the lowest viral load (highest Ct values) obtained for both Omicron and Delta variants. Interestingly, regardless of the vaccine type used, our study revealed that Delta variant produced significantly higher viral loads (lower Ct values) compared with the Omicron variant, where the latter was more commonly associated with younger patients. Viral spread is a crucial factor that can help determine the future of the pandemic. Thus, prioritizing vaccines that will play a role in not only preventing severe disease but also in limiting viral load and spread may contribute to infection control strategies. 相似文献
9.
10.
Dokucu AI Ozdemir E Oztürk H Otçu S Onen A Ciğdem K Kaya M Bükte Y Yücesan S 《International urology and nephrology》2000,32(1):3-8
We analysed the inter-relationships of the cause and the type of trauma, the presence of pelvic fracture, the associated intraabdominal
organ injuries,and the morbidity and mortality rates in 154 patients presenting and being treated for UGT between 1983 and
1997.The cause of injury was blunt in 77% of cases and penetrating in 13%. The most frequently injured organs were kidney
followed by urethra and bladder. Bowels, liver and spleen were the most frequently associated injured organs. Moreover, bladder
injuries were strongly associated with bowel injuries (p < 0.0001). Hemodynamically normal 49 children with minor or major kidney injuries were managed conservatively. Hemodynamically
non-stable 11 patients were explored.The majority of urogenital injuries can be managed conservatively evenwhen associated
with intraabdominal organ injuries. Solid genitourinary organ injuries may accompany more frequently to intraperitoneal solidorgan
injury. Whereas, non-solid genitourinary organ injuries may more frequently associated with injuries of intraperitoneal hollow
viscus.
This revised version was published online in August 2006 with corrections to the Cover Date. 相似文献