Physicochemical and antimicrobial properties of chlorine-containing compositions ciaref and DP-1

The paper presents the results of the physicochemical properties and corrosive activity of the new chlorine-containing compositions Ciaref and DP-1. Various microbiological, biochemical, and biophysical studies were conducted to examine different aspects of the mechanism of action of Ciaref and DP-1 on vegetative (Francisella tularensis) and sporal (Bacillus turingiensis) microorganisms. Suspension, test-surface irrigation, and aerosol techniques were employed under close industrial conditions to study the disinfecting properties of the agents in bacterial and sporal contamination.     

Low-intensity infrared laser radiation in the diagnosis and combined treatment of acute nonspecific lymphadenitis of the face and neck in children

Clinical course of acute nonspecific lymphadenitis of the face and neck is studied in 241 patients aged 1-14 years in order to improve the diagnosis and therapy of this condition. General clinical examinations were supplemented by laser biophotometry and assessment of the activities of some local defense factors (lysozyme, beta-lysine, secretory and serum IgA). Multiple-modality treatment for the first time included magnetic laser therapy (MLT), and its efficacy is assessed. Results of biophotometry helped define objective criteria for the diagnosis and evaluation of treatment efficacy in children with acute lymphadenitis of the face and neck. MLT proved to be a highly effective treatment modality, decreasing the inflammation and correcting local (oral) defense factors. Use of MLT accelerated all phases of the inflammatory process, promoted its regression at the serous stage, and decreased the incidence of suppurative forms of acute lymphadenitis by 40%.     

Changes in the level of DNA minor bases in salivary gland inflammation and its correction with antioxidants

In the experiment with guinea pigs at contact sialoadenitis reproduction (karragenine inflammation of soft tissues of the oral cavity) it was established that in DNA of salivary glands cells and the neighbouring tissues the content of 5-methylcytosine was decreased, it being normalized at "Triovit" antioxidant complex together with cvercitynum correction. The content of DNA 8-hydroxyguanine is characterized by a wide range of data and in absolute values increases in inflammation, but decreases after antioxidant correction. The role of the changes discovered is discussed.     

The dynamics of the healing of experimentally reproduced bone defects filled with different polyacrylamide gel-based compounds

Time course of healing of standard osseous defects by introduction of polyacrylamide gel (PAG)-based materials was studied in rat experiments. PAG did not prevent the formation of soft-tissue and osseous regenerate in bone defects. Addition of hydroxyapatite, bactericidal agent, and lysozyme to PAG-based composition led in some cases to development of chronic inflammation and giant-cell reaction in osseous wound and to inhibition of the reparative processes.     

Potentialities of life quality evaluation for gastroenterological patients

Quality of life (QL) was studied in 112 patients with gastroenterological diseases: 29 cases of gastric ulcer (GU), 53 cases of duodenal ulcer (DU) and 30 cases of chronic pancreatitis (CP). QL was judged according to the test of the Cardiological Research Center of the RAMS. QL in the above gastroenterological diseases was related to restrictions in the diet, emotional and muscular load, long-term treatment. The integral quantitative indices of QL were worse in CP and GU than in DU, and deteriorated with the disease duration and severity. A close correlation was found between QL and subjective symptoms of the disease, especially pain syndrome. The proposed approach to qualitative and quantitative assessment of gastroenterological patients's quality of life adequately reflects this complex phenomenon and closely correlated with clinical evidence.