Association of chloride intracellular channel 4 and Indian hedgehog proteins with survival of patients with pancreatic ductal adenocarcinoma

Pancreatic cancer is the fourth most common cause of cancer‐related mortality. Novel molecular biomarkers need to be identified for personalized medicine and to improve survival. The aim of this study was to examine chloride intracellular channel 4 (CLIC4) and Indian Hedgehog (Ihh) expression in benign and malignant lesions of the pancreas and to examine the eventual association between CLIC4 and Ihh expression, with clinicopathological features and prognosis of pancreatic cancer. A retrospective study of specimens collected from January 2000 to December 2011 at the Department of Pathology of the Second and Third Xiangya Hospitals, Central South University was undertaken to explore this question. Immunohistochemistry of CLIC4 and Ihh was performed with EnVision^? in 106 pancreatic ductal adenocarcinoma specimens, 35 paracancer samples (2 cm away from the tumour, when possible or available), 55 benign lesions and 13 normal tissue samples. CLIC4 and Ihh expression in pancreatic ductal adenocarcinoma were significantly higher than in paracancer tissue and benign lesions (CLIC4: P = 0.009 and Ihh: P < 0.0001; CLIC4: P = 0.0004 and Ihh: P = 0.0001 respectively). CLIC4 and Ihh expression was negative in normal pancreatic tissues. The expression of CLIC4 and Ihh was associated significantly with tumour grade, lymph node metastasis, tumour invasion and poor overall survival. Thus CLIC4 and Ihh could serve as biological markers for the progression, metastasis and/or invasiveness of pancreatic ductal adenocarcinoma.     

以反复腹水为表现的嗜酸细胞性胃肠炎2例

以腹水为表现的嗜酸细胞性胃肠炎临床少见,表现特殊.本文2例嗜酸细胞性胃肠炎以反复腹水为主要临床表现,血及腹水嗜酸性粒细胞增多,骨髓涂片嗜酸比例明显增多,胃黏膜活检阳性率不高,对糖皮质激素治疗有效.临床对原因不明的腹水,应警惕嗜酸细胞性胃肠炎可能.     

高效建立牙齿三维有限元模型

有限元分析法应用于口腔研究首先需要建立计算机口腔模型，目前的文献对建模的过程没有做详细的阐述。本文运用高端的建模与分析软件，以建立一个牙齿计算机模型为例，阐述一种高效建立有限元分析模型的基本思路和方法，为从事医学有限元分析法相关研究的科研人员提供参考。     

本草名词艾叶演变探析

艾作为一味中药,其名称最早出现在《诗经》中,其后又在本草古籍中称为艾蒿、灸草、蕲艾、黄草、医草、家艾、甜艾、草蓬、艾蓬、狼尾蒿子、香艾、野莲头、阿及艾、艾叶等等,其功用和主治也发生了变化,文章试就艾的发展演变进行探讨。     

血尿康方治疗对IgA肾病患者炎性因子的影响

目的探讨血尿康方对IgA肾病患者炎症因子的影响。方法选取IgA肾病患者60例,将其随机分为治疗组和对照组,各30例。对照组给予常规治疗,治疗组在对照组的基础上辅以血尿康方治疗,两组均连续治疗12周。比较两组临床疗效和临床症状改善情况,检测并比较两组患者血清炎症因子的变化。结果治疗组总有效率为93.33%,显著高于对照组的73.33%(P0.05);与治疗前比较,治疗后两组24 h UTP、尿RBC计数显著降低,且治疗组低于对照组(P0.05或P0.01);与治疗前比较,治疗后两组血清IL-12、IL-15及IL-18水平均明显降低,且治疗组低于对照组(P0.01)。结论血尿康方可明显改善IgA肾病患者血尿和蛋白尿等症状,有效抑制机体炎症反应,疗效显著优于常规治疗。