全文获取类型
收费全文 | 153934篇 |
免费 | 50760篇 |
国内免费 | 5443篇 |
专业分类
耳鼻咽喉 | 2294篇 |
儿科学 | 5294篇 |
妇产科学 | 1357篇 |
基础医学 | 23161篇 |
口腔科学 | 6309篇 |
临床医学 | 22863篇 |
内科学 | 33152篇 |
皮肤病学 | 8228篇 |
神经病学 | 16164篇 |
特种医学 | 4980篇 |
外国民族医学 | 29篇 |
外科学 | 21182篇 |
综合类 | 17101篇 |
现状与发展 | 15篇 |
一般理论 | 24篇 |
预防医学 | 10795篇 |
眼科学 | 3547篇 |
药学 | 15057篇 |
77篇 | |
中国医学 | 5942篇 |
肿瘤学 | 12566篇 |
出版年
2024年 | 232篇 |
2023年 | 1029篇 |
2022年 | 2773篇 |
2021年 | 4865篇 |
2020年 | 7800篇 |
2019年 | 12835篇 |
2018年 | 12279篇 |
2017年 | 13821篇 |
2016年 | 14090篇 |
2015年 | 15383篇 |
2014年 | 16283篇 |
2013年 | 16784篇 |
2012年 | 10729篇 |
2011年 | 11272篇 |
2010年 | 14143篇 |
2009年 | 9663篇 |
2008年 | 7366篇 |
2007年 | 5835篇 |
2006年 | 5727篇 |
2005年 | 4616篇 |
2004年 | 3700篇 |
2003年 | 3416篇 |
2002年 | 3069篇 |
2001年 | 2594篇 |
2000年 | 2283篇 |
1999年 | 1609篇 |
1998年 | 899篇 |
1997年 | 863篇 |
1996年 | 708篇 |
1995年 | 649篇 |
1994年 | 598篇 |
1993年 | 317篇 |
1992年 | 371篇 |
1991年 | 302篇 |
1990年 | 205篇 |
1989年 | 193篇 |
1988年 | 192篇 |
1987年 | 171篇 |
1986年 | 140篇 |
1985年 | 102篇 |
1984年 | 55篇 |
1983年 | 39篇 |
1982年 | 20篇 |
1981年 | 24篇 |
1980年 | 12篇 |
1979年 | 14篇 |
1978年 | 7篇 |
1974年 | 6篇 |
1971年 | 5篇 |
1949年 | 5篇 |
排序方式: 共有10000条查询结果,搜索用时 31 毫秒
52.
目的探讨1 470 nm激光剜除治疗高危前列腺增生的手术技巧及临床效果。
方法回顾分析2018年6月至2018年9月中山大学附属第三医院泌尿外科采用1 470 nm激光治疗共89例高危前列腺增生患者的临床资料,年龄平均(68±3)岁,前列腺体积(57.4±2.6)ml。所有患者均采用"寻找层面,先易后难,剜切结合"的层面递进法思路行激光腔内前列腺剜除术,比较患者术中及术后情况。
结果89例均顺利完成手术,与术前相比,术后3个月患者最大尿流率明显增加,[(6.9±2.1) ml/s vs(19.8±3.6) ml/s]。国际前列腺症状评分显著好转,[(24.6±1.7) vs(8.0±1.2)]。术中无输血、无电切综合征、无直肠和膀胱穿孔病例,无输尿管损伤、大出血、心脑血管意外等严重并发症发生。
结论层面递进法激光剜除技术构想对于高危前列腺增生外科包膜层面的寻找、减少术后并发症有独到优势,且易于掌握,或可为业界同行提供一个新的思路。 相似文献
53.
54.
目的探讨不同介入模式在肝癌治疗中的应用分析。方法选取我院肝癌患者130例,将其分为三组,其中,一组患者采用经肝动脉化疗栓塞术(TACE)治疗,二组患者采用肝门静脉化疗栓塞术(PVCE)治疗,三组患者在前两组患者治疗的基础上进行经皮肝穿刺乙醇消融(PEI)治疗,对比分析三组患者的治疗效果。结果一组治疗总有效率为27.5%,二组治疗总有效率为35%,三组治疗总有效率为92%,三组相对于一、二组来说治疗效果更佳,差异具有统计学意义(P0.05)。结论肝动脉化疗栓塞术、肝门静脉化疗栓塞术和经皮肝穿刺乙醇消融治疗相结合治疗肝癌患者,能够有效提高患者治疗效果,稳定患者病情。 相似文献
55.
The Transient Receptor Potential Vanilloid 1 Antagonist Capsazepine Improves the Impaired Lung Mechanics during Endotoxemia
下载免费PDF全文
![点击此处可从《Basic & clinical pharmacology & toxicology》网站下载免费的PDF全文](/ch/ext_images/free.gif)
Layla D. M. Cabral Alexandre Giusti‐Paiva 《Basic & clinical pharmacology & toxicology》2016,119(5):421-427
Acute lung injury (ALI) caused by systemic inflammatory response remains a leading cause of morbidity and mortality in critically ill patients. Management of patients with sepsis is largely limited to supportive therapies, reflecting an incomplete understanding of the underlying pathophysiology. Furthermore, there have been limited advances in the treatments for ALI. In this study, lung function and a histological analysis were performed to evaluate the impact of transient receptor potential vanilloid‐1 receptor (TRPV1) antagonist (capsazepine; CPZ) on the lipopolysaccharide (LPS)‐induced lung injury in mice. For this, adult mice pre‐treated with CPZ or vehicle received intraperitoneal injections of LPS or saline and 24 hr after, the mice were anaesthetized, and lung mechanics was evaluated. The LPS‐challenged mice exhibited substantial mechanical impairment, characterized by increases in respiratory system resistance, respiratory system elastance, tissue damping and tissue elastance. The pre‐treatment with CPZ prevented the increase in respiratory system resistance and decreased the increase in tissue damping during endotoxemia. In addition, mice pre‐treated with CPZ had an attenuated lung injury evidenced by reduction on collapsed area of the lung parenchyma induced by LPS. This suggests that the TRPV1 antagonist capsazepine has a protective effect on lung mechanics in ALI during endotoxemia and that it may be a target for enhanced therapeutic efficacy in ALI. 相似文献
56.
57.
Weiyu Ye Anna Olsson-Brown Robert A. Watson Vincent T. F. Cheung Robert D. Morgan Isar Nassiri Rosalin Cooper Chelsea A. Taylor Umair Akbani Oliver Brain Rubeta N. Matin Nicholas Coupe Mark R. Middleton Mark Coles Joseph J. Sacco Miranda J. Payne Benjamin P. Fairfax 《British journal of cancer》2021,124(10):1661
Background Immune checkpoint blockers (ICBs) activate CD8+ T cells, eliciting both anti-cancer activity and immune-related adverse events (irAEs). The relationship of irAEs with baseline parameters and clinical outcome is unclear.Methods Retrospective evaluation of irAEs on survival was performed across primary (N = 144) and secondary (N = 211) independent cohorts of patients with metastatic melanoma receiving single agent (pembrolizumab/nivolumab—sICB) or combination (nivolumab and ipilimumab—cICB) checkpoint blockade. RNA from pre-treatment and post-treatment CD8+ T cells was sequenced and differential gene expression according to irAE development assessed.Results 58.3% of patients developed early irAEs and this was associated with longer progression-free (PFS) and overall survival (OS) across both cohorts (log-rank test, OS: P < 0.0001). Median survival for patients without irAEs was 16.6 months (95% CI: 10.9–33.4) versus not-reached (P = 2.8 × 10−6). Pre-treatment monocyte and neutrophil counts, but not BMI, were additional predictors of clinical outcome. Differential expression of numerous gene pathway members was observed in CD8+ T cells according to irAE development, and patients not developing irAEs demonstrating upregulated CXCR1 pre- and post-treatment.Conclusions Early irAE development post-ICB is associated with favourable survival in MM. Development of irAEs is coupled to expression of numerous gene pathways, suggesting irAE development in-part reflects baseline immune activation.Subject terms: Immunotherapy, Melanoma 相似文献
58.
59.
Maxime Lafond Shin Yoshizawa Shin‐ichiro Umemura 《Journal of ultrasound in medicine》2019,38(3):567-580
Sonodynamic therapy (SDT) consists of the synergetic interaction between ultrasound and a chemical agent. In SDT, the cytotoxicity is triggered by ultrasonic stimuli, notably through cavitation. The unique features of SDT are relevant in the clinical context more than ever: the need for efficacy, accuracy, and safety while being noninvasive and preserving the patient's quality of life. However, despite the promising results of this technique, only a few clinical reports describe the use of SDT. The objective of this article is to provide an extensive overview of the clinical and preclinical research conducted in vivo on SDT, to identify the limitations, and to detail the developed strategies to overcome them. 相似文献
60.
Sarah E. Sheppard Laura Elizabeth Anderson Cathryn Sibbald Colleen Cotton Elizabeth Bhoj Marissa J. Perman Leslie Castelo‐Soccio 《Pediatric dermatology》2019,36(6):1007-1009
Epidermolysis bullosa simplex (EBS) is a skin fragility disorder resulting from mutations of structural proteins in the epidermis. We provide a brief report of long‐term survival and reproduction in a mother with EBS due to keratin 5 (KRT5) c.1429G > A (p.E477K) mutation, which causes a particularly severe form of the disease. 相似文献