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31.
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Salwa AlDahlawi BDS MSc ; Ameneh Eslami MD ; Lari Häkkinen DDS PhD ; Hannu S. Larjava DDS PhD 《Wound repair and regeneration》2006,14(3):289-297
The alphavbeta6 integrin is an exclusively epithelial integrin that is highly expressed during fetal development. In adult tissue, alphavbeta6 integrin is expressed during inflammation, carcinogenesis, and in wound healing. We previously reported that alphavbeta6 integrin is highly expressed in poorly healing human wounds and its over-expression is associated with chronic wounds in a mouse model. The objective of this study was to investigate the role of alphavbeta6 integrin in compromised wound healing induced by hydrocortisone treatment or aging by using young and old mice deficient in or overexpressing the beta6 integrin subunit in the epidermis. Untreated aged beta6 integrin-deficient (beta6-/-) animals showed a significant delay in wound healing when compared to their age-matched controls or younger beta6-/- mice. The most significant delay was observed at the stages where granulation tissue deposition was occurring. Hydrocortisone treatment significantly delayed wound healing in wild-type and beta6 integrin-deficient mice in comparison with the untreated controls. However, hydrocortisone treatment in beta6 integrin overexpressing animals did not cause a significant delay in wound healing. The results of this study suggest that alphavbeta6 integrin plays an important role in wound healing in animals compromised by either age or stress mimicked by hydrocortisone. 相似文献
33.
Eric T. Stoopler DMD res Pinto DMD Faizan Alawi DDS Sree Raghavendra DMD Ricardo Boyce Jr. DDS David Porter MD Thomas P. Sollecito DMD 《Special care in dentistry》2004,24(2):65-69
Acute myelogenous leukemia (AMU is a hematologic disorder that is characterized by an abnormal proliferation of immature myeloid cells. Granulocytic sarcomas are clusters of leukemic myeloid cells that may develop as a result of AML. Oral manifestations of AML are common and often involve enlargements of the gingiva and/or mucosal tissue from direct leukemia cell infiltration. We describe the case history of a 50-year-old man who had an ulcera-tive lesion of the oral mucosa that was determined to be a granulocytic sarcoma of AML-M0 subtype. The combination of both the subtype and clinical presentation of the leukemia makes this presentation unusual, and to the best of our knowledge, of a type that has not been previously reported in the literature. 相似文献
34.
当归对衰老小鼠脑组织细胞凋亡及胸腺指数的影响 总被引:2,自引:0,他引:2
目的:研究当归的抗衰老作用及作用机制。方法:用D—半乳糖诱导小鼠制成衰老模型,同时给予不同剂量的当归水煎剂,观察当归对脑组织细胞凋亡及胸腺指数的影响。结果:当归能明显抑制小鼠脑组织细胞凋亡,提高胸腺指数。结论:当归具有抗衰老作用。 相似文献
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Smith Kevin C. BA BSc MD FACP FRCPC Melnychuk Michael BSc DDS 《Dermatologic surgery》2005,31(S4):1635-1637
Background. Injection of filler substances into the lips is painful, and many patients also find the injection of local or regional anesthesia into the lips painful.
Objective. To develop a highly effective and painless form of anesthesia to facilitate injection of filler substances into the lips.
Methods. Five percent lidocaine cream was applied simultaneously to the skin, vermilion, and mucosa of the lips (with the use of a barrier to keep the cream in contact with the mucosa and out of the rest of the mouth) for 20 to 30 minutes.
Results. Profound anesthesia of the lips was reliably produced, with no complications.
Conclusions. This "anesthetic cream block" is easier to perform and better tolerated than injectable anesthetics. Use of this technique is likely to expand the range of physicians who perform filler injections on the lips and will probably also expand the range of patients who wish to have filler injections done on their lips and who (because they had little or no discomfort) are willing to return for additional filler injections in the future. 相似文献
Objective. To develop a highly effective and painless form of anesthesia to facilitate injection of filler substances into the lips.
Methods. Five percent lidocaine cream was applied simultaneously to the skin, vermilion, and mucosa of the lips (with the use of a barrier to keep the cream in contact with the mucosa and out of the rest of the mouth) for 20 to 30 minutes.
Results. Profound anesthesia of the lips was reliably produced, with no complications.
Conclusions. This "anesthetic cream block" is easier to perform and better tolerated than injectable anesthetics. Use of this technique is likely to expand the range of physicians who perform filler injections on the lips and will probably also expand the range of patients who wish to have filler injections done on their lips and who (because they had little or no discomfort) are willing to return for additional filler injections in the future. 相似文献
37.
做好医疗惠民工作是一项民主工程,对于减轻低保特困人群的医疗负担,构建和谐社会具有重要意义。文章对近2年绍兴市惠民医院的管理实践工作进行总结,作为继续完善这方面工作的参考。 相似文献
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Neslihan Eminkahyagil DDS MSc PhD ; Selim Erkut DDS PhD 《Journal of prosthodontics》2006,15(5):316-320
Immediate chairside replacement of an extracted anterior tooth may contribute to a patient's comfort, treatment acceptance, and expectations of treatment; however, fabrication of a custom restoration in the anterior region of the mouth may result in an esthetic compromise for patients during the fabrication period. Chairside tooth replacement is an excellent application of fiber-reinforced composite resin technology. This article presents an innovative, affordable chairside procedure in which Ribbond Multi-Purpose Bondable Reinforcement Ribbon is used to replace a single extracted anterior tooth using the patient's own tooth. 相似文献
40.