首页 | 本学科首页   官方微博 | 高级检索  
文章检索
  按 检索   检索词:      
出版年份:   被引次数:   他引次数: 提示:输入*表示无穷大
  收费全文   1995050篇
  免费   152509篇
  国内免费   3563篇
耳鼻咽喉   29130篇
儿科学   63295篇
妇产科学   58838篇
基础医学   289949篇
口腔科学   57025篇
临床医学   173226篇
内科学   384733篇
皮肤病学   40808篇
神经病学   158287篇
特种医学   78601篇
外国民族医学   526篇
外科学   309458篇
综合类   47611篇
现状与发展   3篇
一般理论   578篇
预防医学   152020篇
眼科学   46957篇
药学   151541篇
  1篇
中国医学   3798篇
肿瘤学   104737篇
  2018年   18349篇
  2015年   18364篇
  2014年   25732篇
  2013年   39350篇
  2012年   53733篇
  2011年   57048篇
  2010年   33493篇
  2009年   31555篇
  2008年   54759篇
  2007年   59488篇
  2006年   59780篇
  2005年   58872篇
  2004年   57052篇
  2003年   55180篇
  2002年   53814篇
  2001年   85766篇
  2000年   88000篇
  1999年   74859篇
  1998年   22063篇
  1997年   19965篇
  1996年   19994篇
  1995年   18851篇
  1994年   18015篇
  1993年   16723篇
  1992年   61809篇
  1991年   60833篇
  1990年   59906篇
  1989年   58117篇
  1988年   54263篇
  1987年   53350篇
  1986年   50920篇
  1985年   48903篇
  1984年   37196篇
  1983年   32157篇
  1982年   19667篇
  1981年   17756篇
  1980年   16530篇
  1979年   36244篇
  1978年   25798篇
  1977年   21984篇
  1976年   20623篇
  1975年   22467篇
  1974年   27098篇
  1973年   26173篇
  1972年   24869篇
  1971年   23073篇
  1970年   21733篇
  1969年   21022篇
  1968年   19451篇
  1967年   17452篇
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
81.
82.
A 17‐year‐old boy presented with recurring severe dermatitis of the face of 5‐months duration that resembled impetigo. He had been treated with several courses of antibiotics without improvement. Biopsy showed changes consistent with allergic contact dermatitis and patch testing later revealed sensitization to benzoyl peroxide, which the patient had been using for the treatment of acne vulgaris.  相似文献   
83.
Abstract

Objective: To understand the origin of extremely high gonadotropin levels in a perimenopausal woman.

Methods: A 52-year-old woman with a 2?months of amenorrhea followed spontaneous menstrual cycles recovery was referred to our outpatient clinic with elevated follicle-stimulating hormone (FSH, 483 mUI/ml), luteinizing hormone (LH, 475 mUI/ml) and prolactin (PRL, 173?ng/ml). She was known to take levosulpiride. The gonadotropin levels did not fit with the clinical features.

Results: A gonadotroph tumor was ruled out. Further analysis confirmed constantly high FSH, LH and PRL levels. The measurements were repeated using different analytical platforms with different results. After serial dilutions, nonlinearity was present suggesting an immunoassay interference. After post-polyethylene glycol recovery, hormone levels appeared in the normal range. Anti-goat antibodies were recognized in the serum of the patient.

Conclusions: This case report shows a case of falsely abnormal high gonadotropin and PRL levels in a woman during menopause transition. In the clinical practice the evaluation of gonadotropin profile is not recommended at this age, but the abnormal levels stimulated further evaluation. An interference in the assay due to anti-goat antibodies resulted in abnormally high level of FSH and LH. A strict collaboration between clinicians and the laboratory is needed, when laboratory findings do not correspond to clinical findings.  相似文献   
84.
85.
86.
87.
88.
89.
90.
Background Immune checkpoint blockers (ICBs) activate CD8+ T cells, eliciting both anti-cancer activity and immune-related adverse events (irAEs). The relationship of irAEs with baseline parameters and clinical outcome is unclear.Methods Retrospective evaluation of irAEs on survival was performed across primary (N = 144) and secondary (N = 211) independent cohorts of patients with metastatic melanoma receiving single agent (pembrolizumab/nivolumab—sICB) or combination (nivolumab and ipilimumab—cICB) checkpoint blockade. RNA from pre-treatment and post-treatment CD8+ T cells was sequenced and differential gene expression according to irAE development assessed.Results 58.3% of patients developed early irAEs and this was associated with longer progression-free (PFS) and overall survival (OS) across both cohorts (log-rank test, OS: P < 0.0001). Median survival for patients without irAEs was 16.6 months (95% CI: 10.9–33.4) versus not-reached (P = 2.8 × 10−6). Pre-treatment monocyte and neutrophil counts, but not BMI, were additional predictors of clinical outcome. Differential expression of numerous gene pathway members was observed in CD8+ T cells according to irAE development, and patients not developing irAEs demonstrating upregulated CXCR1 pre- and post-treatment.Conclusions Early irAE development post-ICB is associated with favourable survival in MM. Development of irAEs is coupled to expression of numerous gene pathways, suggesting irAE development in-part reflects baseline immune activation.Subject terms: Immunotherapy, Melanoma  相似文献   
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号