全文获取类型
收费全文 | 1176篇 |
免费 | 62篇 |
国内免费 | 7篇 |
专业分类
耳鼻咽喉 | 17篇 |
儿科学 | 12篇 |
妇产科学 | 42篇 |
基础医学 | 81篇 |
口腔科学 | 31篇 |
临床医学 | 80篇 |
内科学 | 261篇 |
皮肤病学 | 12篇 |
神经病学 | 71篇 |
特种医学 | 31篇 |
外科学 | 416篇 |
综合类 | 5篇 |
预防医学 | 47篇 |
眼科学 | 30篇 |
药学 | 29篇 |
中国医学 | 1篇 |
肿瘤学 | 79篇 |
出版年
2024年 | 1篇 |
2023年 | 21篇 |
2022年 | 31篇 |
2021年 | 61篇 |
2020年 | 38篇 |
2019年 | 37篇 |
2018年 | 49篇 |
2017年 | 37篇 |
2016年 | 47篇 |
2015年 | 54篇 |
2014年 | 93篇 |
2013年 | 86篇 |
2012年 | 93篇 |
2011年 | 111篇 |
2010年 | 63篇 |
2009年 | 61篇 |
2008年 | 62篇 |
2007年 | 68篇 |
2006年 | 28篇 |
2005年 | 33篇 |
2004年 | 27篇 |
2003年 | 18篇 |
2002年 | 21篇 |
2001年 | 14篇 |
2000年 | 15篇 |
1999年 | 17篇 |
1998年 | 3篇 |
1997年 | 1篇 |
1996年 | 1篇 |
1994年 | 1篇 |
1993年 | 4篇 |
1992年 | 8篇 |
1991年 | 6篇 |
1990年 | 5篇 |
1989年 | 2篇 |
1988年 | 6篇 |
1987年 | 3篇 |
1986年 | 1篇 |
1985年 | 2篇 |
1984年 | 3篇 |
1983年 | 1篇 |
1981年 | 1篇 |
1980年 | 2篇 |
1979年 | 5篇 |
1978年 | 1篇 |
1976年 | 1篇 |
1970年 | 1篇 |
1966年 | 1篇 |
排序方式: 共有1245条查询结果,搜索用时 46 毫秒
71.
Marko Topalovic Vasileios Exadaktylos Marc Decramer Thierry Troosters Daniel Berckmans Wim Janssens 《Medical & biological engineering & computing》2014,52(12):997-1006
Chronic obstructive pulmonary disease (COPD) is characterized by expiratory airflow limitation, but current diagnostic criteria only consider flow till the first second and are therefore strongly debated. We aimed to develop a data-based individualized model for flow decline and to explore the relationship between model parameters and COPD presence. A second-order transfer function model was chosen and the model parameters (namely the two poles and the steady state gain (SSG)) from 474 individuals were correlated with COPD presence. The capability of the model to predict disease presence was explored using 5 machine learning classifiers and tenfold cross-validation. Median (95 % CI) poles in subjects without disease were 0.9868 (0.9858–0.9878) and 0.9333 (0.9256–0.9395), compared with 0.9929 (0.9925–0.9933) and 0.9082 (0.9004–0.9140) in subjects with COPD (p < 0.001 for both poles). A significant difference was also found when analysing the SSG, being lower in COPD group 3.8 (3.5–4.2) compared with 8.2 (7.8–8.7) in subjects without (p < 0.0001). A combination of all three parameters in a support vector machines corresponded with highest sensitivity of 85 %, specificity of 98.1 % and accuracy of 88.2 % to COPD diagnosis. The forced expiration of COPD can be modelled by a second-order system which parameters identify most COPD cases. Our approach offers an additional tool in case FEV1/FVC ratio-based diagnosis is doubted. 相似文献
72.
Vasileios A Kontogeorgakos Dionysios J Papachristou Konstantinos N Malizos 《Pediatrics international》2014,56(3):417-419
Langerhans cell histiocytosis is a rare neoplastic proliferative disorder of the Langerhans cells. The clinical course is variable, ranging from a low symptomatic single bone lesion to fatal multiple organ involvement. Rarely, the sternum can be the first and single location of the disease. We report on a 12‐year‐old boy who presented with an aggressive lytic lesion of the proximal sternum associated with local pain and afternoon fever. Histopathological analysis of the closed biopsy specimen indicated eosinophilic granuloma of bone/Langerhans cell histiocytosis. Soon after the biopsy procedure the pain and fever subsided. Computed tomography at 2 months showed healing of the lytic lesion. The patient received no other type of treatment. At 2 year follow up he was symptom and disease free. 相似文献
73.
Ioannis Tamposis Ioannis Tsougos Anastasios Karatzas Katerina Vassiou Marianna Vlychou Vasileios Tzortzis 《Applied clinical informatics》2022,13(1):91
Background and Objective Prostate cancer (PCa) is a severe public health issue and the most common cancer worldwide in men. Early diagnosis can lead to early treatment and long-term survival. The addition of the multiparametric magnetic resonance imaging in combination with ultrasound (mpMRI-U/S fusion) biopsy to the existing diagnostic tools improved prostate cancer detection. Use of both tools gradually increases in every day urological practice. Furthermore, advances in the area of information technology and artificial intelligence have led to the development of software platforms able to support clinical diagnosis and decision-making using patient data from personalized medicine. Methods We investigated the current aspects of implementation, architecture, and design of a health care information system able to handle and store a large number of clinical examination data along with medical images, and produce a risk calculator in a seamless and secure manner complying with data security/accuracy and personal data protection directives and standards simultaneously. Furthermore, we took into account interoperability support and connectivity to legacy and other information management systems. The platform was implemented using open source, modern frameworks, and development tools. Results The application showed that software platforms supporting patient follow-up monitoring can be effective, productive, and of extreme value, while at the same time, aiding toward the betterment medicine clinical workflows. Furthermore, it removes access barriers and restrictions to specialized care, especially for rural areas, providing the exchange of medical images and patient data, among hospitals and physicians. Conclusion This platform handles data to estimate the risk of prostate cancer detection using current state-of-the-art in eHealth systems and services while fusing emerging multidisciplinary and intersectoral approaches. This work offers the research community an open architecture framework that encourages the broader adoption of more robust and comprehensive systems in standard clinical practice. 相似文献
74.
Serial computed tomography is rarely necessary in patients with acute pancreatitis: a prospective study in 102 patients 总被引:7,自引:0,他引:7
Munoz-Bongrand N Panis Y Soyer P Riché F Laisné MJ Boudiaf M Valleur P 《Journal of the American College of Surgeons》2001,193(2):146-152
BACKGROUND: CT has proved to be helpful in patients with acute pancreatitis for differentiating between mild and severe forms. Followup of acute pancreatitis with CT has been advocated but rarely studied. The aim of this study was to determine if late CT performed at day 7 might be helpful in establishing the prognosis or the type of complications, and to select a subgroup of patients in whom CT could be beneficial. STUDY DESIGN: Contrast-enhanced CT was performed at the admission day and 7 days after admission in 102 patients admitted for acute pancreatitis. The extent of pancreatic inflammation was classified according to Balthazar grade, and intrapancreatic necrosis on these examinations was prospectively assessed and compared with clinical and biologic data and with patient outcomes. RESULTS: Among 102 patients, complications developed in 24 (23%). Complications developed in only 8% of patients with Ranson score <2, making routine early CT unnecessary. For the patients with Ranson score <2 and Balthazar grades A and B at day 1 CT, late CT seemed to be useless. Complication was suspected by clinical and biologic tests before day 7 in 22 of 24 complicated patients (92%), suggesting that CT could be proposed only in cases of clinical or biologic deterioration. Late CT was correlated with a complicated course in patients with Balthazar grades D and E or intrapancreatic necrosis >50%. Late CT was predictive of complications in cases of intrapancreatic necrosis enlarging since the first examination. CONCLUSIONS: Our study showed that in acute pancreatitis: 1) there is little justification for systematic early CT, especially in patients with Ranson score <2, and 2) late CT does not need to be performed routinely, but only in cases of clinical or biologic worsening. 相似文献
75.
Konstantinos Malizos Maria Ioannou Vasileios Kontogeorgakos 《Strategies in trauma and limb reconstruction (Online)》2013,8(1):63-66
Ancient schwannomas are benign long standing schwannomas of the neural sheaths. Histological findings are these seen as in conventional schwannomas, but ancient schwannomas additionally demonstrate cystic hemorrhagic changes and degenerative nuclei with pleomorphism and hyperchromasia. Due to the nuclear atypia, and cystic degeneration, ancient schwannomas might be confused with malignant tumors on histology and imaging, leading to a radical surgical approach. The median nerve is rarely affected. We present a rare case of an ancient schwannoma involving the median nerve at the mid humerus. The tumor slowly grew up within ten years and become symptomatic with local pain, mild numbness in the distribution of the median nerve in the palm and Tinel’s test. The tumor was successfully removed by separating it from the nerve fascicles to negative margins. Post-operatively local symptoms relieved but minor sensory loss in the median nerve distribution in the palm was noticed which improved in the following six months. Ancient schwannomas can be misdiagnosed as sarcomas due to specific imaging and histologic findings. Patients’ physical examination, history and fine radiologic and pathology features should be cautiously interpreted in order to achieve correct diagnosis and avoid unnecessary wide tumor excisions. 相似文献
76.
A. Senéjoux Y. Panis L. Siproudhis J. Lefevre J. D. Zeitoun X. Treton 《C?lon & Rectum》2012,6(4):263-271
77.
78.
79.
80.
Factors Associated with Clinically Significant Anastomotic
Leakage after Large Bowel Resection: Multivariate Analysis of 707
Patients 总被引:20,自引:0,他引:20
Alves A Panis Y Trancart D Regimbeau JM Pocard M Valleur P 《World journal of surgery》2002,26(4):499-502
The aim of this study was to determine by
univariate and multivariate analyses the factors associated with
clinically significant anastomotic leakage (AL) after large bowel
resection. From 1990 to 1997 a series of 707 patients underwent
colonic or rectal resection (without a stoma). Patients were divided
into two groups: those with clinical anastomotic leakage (group 1) and
those without it (group 2). AL occurred in 43 of 707 patients (6%).
The overall mortality was 2.2% and was significantly higher in
patients with AL than in those without: 5 of 43 (12%) versus 11 of 664
(1.6%), p <0.001. Univariate analysis showed 15
variables associated with the risk of AL: previous abdominal or pelvic
irradiation (p = 0.02), American Society of
Anesthesiologists (ASA) score > 2 (p = 0.04),
leukocytosis (p = 0.02), renal failure
(p = 0.03), steroid treatment (p =
0.01), duration of operation (p = 0.001),
intraoperative septic conditions (p = 0.006), total
colectomy (p = 0.009), transverse colectomy
(p = 0.02), difficulties encountered during
anastomosis (p = 0.001), ileorectal anastomosis
(p = 0.02), colocolic anastomosis (p
= 0.01), abdominal drainage (p = 0.05), and blood
transfusion intraoperatively (p = 0.006) and
postoperatively (p = 0.001). Multivariate analysis
showed that only preoperative leukocytosis (p = 0.04),
intraoperative septic conditions (p = 0.001),
difficulties encountered during anastomosis (p =
0.007), colocolic anastomosis (p = 0.004), and
postoperative blood transfusion (p = 0.0007) were
independent factors associated with AL. The risk of AL increased from a
range of 12% to 30% if one risk factor was present, to 38% with two
factors, to 50% with three factors. After colorectal resection and
intraperitoneal anastomosis, a temporary protective stoma is proposed
in selected patients with high risk factors for AL, as observed in our
study. 相似文献