全文获取类型
收费全文 | 762536篇 |
免费 | 54144篇 |
国内免费 | 1434篇 |
专业分类
耳鼻咽喉 | 9942篇 |
儿科学 | 24840篇 |
妇产科学 | 19088篇 |
基础医学 | 119936篇 |
口腔科学 | 21517篇 |
临床医学 | 69272篇 |
内科学 | 145738篇 |
皮肤病学 | 17035篇 |
神经病学 | 54925篇 |
特种医学 | 28221篇 |
外国民族医学 | 116篇 |
外科学 | 111932篇 |
综合类 | 15312篇 |
现状与发展 | 2篇 |
一般理论 | 237篇 |
预防医学 | 55938篇 |
眼科学 | 17378篇 |
药学 | 58121篇 |
3篇 | |
中国医学 | 2499篇 |
肿瘤学 | 46062篇 |
出版年
2021年 | 6379篇 |
2019年 | 6286篇 |
2018年 | 8891篇 |
2017年 | 6819篇 |
2016年 | 7659篇 |
2015年 | 8551篇 |
2014年 | 11512篇 |
2013年 | 17526篇 |
2012年 | 23247篇 |
2011年 | 24356篇 |
2010年 | 14756篇 |
2009年 | 13671篇 |
2008年 | 22571篇 |
2007年 | 24238篇 |
2006年 | 24588篇 |
2005年 | 23008篇 |
2004年 | 22608篇 |
2003年 | 21318篇 |
2002年 | 20912篇 |
2001年 | 38180篇 |
2000年 | 38779篇 |
1999年 | 32119篇 |
1998年 | 8680篇 |
1997年 | 7333篇 |
1996年 | 7559篇 |
1995年 | 7243篇 |
1994年 | 6598篇 |
1993年 | 6149篇 |
1992年 | 24291篇 |
1991年 | 24183篇 |
1990年 | 23518篇 |
1989年 | 23260篇 |
1988年 | 21053篇 |
1987年 | 20428篇 |
1986年 | 19415篇 |
1985年 | 18178篇 |
1984年 | 13332篇 |
1983年 | 11334篇 |
1982年 | 6348篇 |
1979年 | 12115篇 |
1978年 | 8476篇 |
1977年 | 7160篇 |
1976年 | 6872篇 |
1975年 | 7617篇 |
1974年 | 8886篇 |
1973年 | 8475篇 |
1972年 | 7980篇 |
1971年 | 7410篇 |
1970年 | 7117篇 |
1969年 | 6518篇 |
排序方式: 共有10000条查询结果,搜索用时 640 毫秒
81.
82.
Quang Ngoc Nguyen Linh Dieu Vuong Van-Long Truong To Van Ta Nam Trung Nguyen Hung Phi Nguyen Ha Hoang Chu 《Pathology, research and practice》2019,215(5):885-892
Genetic and epigenetic alterations importantly contribute to the pathogenesis of lung cancer. In the study, we measured the frequency and distribution of molecular abnormalities of EGFR as well as the aberrant promoter methylations of BRCA1, MGMT, MLH1, and RASSF1A in Vietnamese lung adenocarcinomas. We investigated the association between genetic and epigenetic alteration, and between each abnormality with clinicopathologic parameters. Somatic EGFR mutation that was found in 49/139 (35.3%) lung adenocarcinomas showed a significant association with young age, female gender, and non-smokers. EGFR overexpression was identified in 82 tumors (59.0%) and statistical relationships with EGFR or BRCA1 methylation but not EGFR mutation. In addition, EGFR, BRCA1, MGMT, MLH1, and RASSF1A methylations were found in 33 (23.7%), 41 (29.5%), 46 (33.1%), 28 (20.1%), and 41 (29.5%) cases of a total of 139 lung adenocarcinomas, respectively. The RASSF1A methylation was found to be linked to the smoking habit. Methylations in MGMT and RASSF1A were also found to correlate with metastasis status. Furthermore, the distribution of EGFR mutation and that of BRCA1, MGMT or RASSF1A methylation were significantly exclusive in lung adenocarcinomas. The main finding of our study demonstrate that epigenetic abnormalities might play a critical role for the lung tumorigenesis in patients with smoking history and metastasis, and partly affect the predictive value of EGFR mutations through blocking expression due to promoter EGFR hypermethylation. Mutually exclusive distribution of genetic and epigenetic alterations reflects differently biological characteristics in the etiology of lung adenocarcinomas. 相似文献
83.
84.
C. M. de Bont N. Eerden W. C. Boelens G. J. M. Pruijn 《Clinical and experimental immunology》2020,199(1):1-8
Neutrophils can form neutrophil extracellular traps (NETs) to capture microbes and facilitate their clearance. NETs consist of decondensed chromatin decorated with anti-microbial proteins. Here, we describe the effect of neutrophil proteases on the protein content of NETs. We show that the neutrophil serine proteases degrade several neutrophil proteins associated with NETs. Interestingly, the anti-bacterial proteins associated with NETs, such as myeloperoxidase, calgranulin B and neutrophil elastase (NE), seem to be less susceptible to proteolytic degradation than other NET proteins, such as actin and MNDA. NETs have been proposed to play a role in autoimmune reactions. Our data demonstrate that a large number of the autoepitopes of NET proteins that are recognized by autoantibodies produced by systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA) patients are also removed by the proteases. In conclusion, neutrophil serine proteases have a major impact on the NET proteome and the proteolytic changes of NET-associated proteins may counteract autoimmune reactions to NET components. 相似文献
85.
Fast,sensitive and specific diagnosis of infections with Leishmania spp. in formalin‐fixed,paraffin‐embedded skin biopsies by cytochrome b polymerase chain reaction
下载免费PDF全文
![点击此处可从《The British journal of dermatology》网站下载免费的PDF全文](/ch/ext_images/free.gif)
M. Gebhardt B. Ertas T.M. Falk N. Blödorn‐Schlicht D. Metze A. Böer‐Auer 《The British journal of dermatology》2015,173(5):1239-1249
86.
87.
88.
89.