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81.
Deniz Peker Vishwas Parekh Ravikumar Paluri Taylor Deal Uma Borate Antonio Di Stasi Shuko Harada Emmanuel Agosto Arroyo Vishnu Reddy 《International journal of hematology》2014,100(5):457-463
Therapy-related myeloid neoplasms (t-MN) have a common origin in prior cytotoxic therapy and/or radiation. These neoplasms include therapy-related acute myeloid leukemia, myelodysplastic syndrome (t-MDS), and myelodysplastic/myeloproliferative neoplasms (t-MDS/MPN). Myeloid sarcoma (MS), on the other hand, is a rare disease manifesting as an extramedullary collection of immature cells of myeloid lineage. Rarer still is therapy-related MS (t-MS), which has not been adequately studied due to its rarity and its lack of recognition as a unique entity among other t-MN. Here, we report what is to our knowledge the first case series of t-MS, with the aim of investigating and establishing salient clinicopathological and molecular features of this entity. 相似文献
82.
Liu Yuan Jaquith Jane M. Mccarthy-Fruin Kathleen Zhu Xingxing Zhou Xian Li Yanfeng Crowson Cynthia Davis John M. Thanarajasingam Uma Zeng Hu 《Clinical rheumatology》2020,39(12):3631-3637
Clinical Rheumatology - To determine the clinical and serologic similarities and differences between inflammatory arthritis induced by immune checkpoint inhibitors (IA-irAE) and rheumatoid... 相似文献
83.
Rashidul Haque Cynthia Snider Yue Liu Jennie Z. Ma Lei Liu Uma Nayak Josyf C. Mychaleckyj Poonum Korpe Dinesh Mondal Mamun Kabir Masud Alam Mark Pallansch M. Steven Oberste William Weldon Beth D. Kirkpatrick William A. Petri Jr. 《Vaccine》2014
Oral vaccines for polio (OPV) and rotavirus are less effective in children in the developing world. The reasons for this are not well understood. We tested for risk factors for poor response to OPV in infants from an urban slum of Dhaka, Bangladesh. Diminished serum neutralizing response to OPV, but not failure of intramuscularly administered vaccines, was associated with malnutrition, diarrhea, and shorter breastfeeding duration. Children with malnutrition (WAZ <−2) had significantly lower OPV 3 titers (p = 0.029). Children who had 2 or more diarrhea episodes during the 1st months of life were more than twice as likely to experience OPV failure as those who had 1 diarrhea episode or no diarrhea (p = 0.0245). In contrast, each additional month in exclusive breastfeeding was associated with an increase in OPV 3 titer by 0.41 (p = 0.0072) and 0.16 (p = 0.0065) at the 25th and 50th percentiles of OPV 3 titers respectively. These data are consistent with a defect in induction of immunity in the gut for OPV but not parenteral vaccines, a defect that may be amenable to intervention in part via promotion of exclusive breastfeeding. 相似文献
84.
Monk Catherine Webster Rachel S. McNeil Rebecca B. Parker Corette B. Catov Janet M. Greenland Philip Bairey Merz C. Noel Silver Robert M. Simhan Hyagriv N. Ehrenthal Deborah B. Chung Judith H. Haas David M. Mercer Brian M. Parry Samuel Polito LuAnn Reddy Uma M. Saade George R. Grobman William A. 《Archives of women's mental health》2020,23(3):361-369
Archives of Women's Mental Health - Maternal stress is a risk factor for adverse pregnancy outcomes (APOs). This study evaluates the associations of prenatal stress and APOs with maternal... 相似文献
85.
Garima Rakheja Uma Handa Ravinder Kaur Phiza Aggarwal Anshu Palta 《Diagnostic cytopathology》2020,48(5):479-482
Primary adrenal lymphoma (PAL) is an extremely rare condition. We describe here, a case of bilateral adrenal lymphoma in a 62‐year‐old man. He later developed subcutaneous masses on the hand and the leg. Fine‐needle aspiration cytology from the adrenals and the soft tissue swellings led to a diagnosis of non‐Hodgkin's lymphoma (NHL). Histopathological examination from the lesion on the leg, confirmed the diagnosis to be B‐cell NHL. The case highlights the cytomorphological findings of this unusual case. Awareness of this entity is essential to differentiate it from other common causes of adrenal enlargement and formulate an appropriate treatment. 相似文献
86.
Garima Rakheja Uma Handa Anita Tahlan Sarabmeet S. Lehl 《Diagnostic cytopathology》2020,48(3):234-238
Amyloidosis is a well‐recognized entity, that can present as a systemic disease, or, uncommonly, as a localized mass. We report here, a rare presentation of amyloidosis presenting as a supraclavicular swelling, diagnosed on fine‐needle aspiration cytology. Subsequent bone marrow examination led to the diagnosis of multiple myeloma. This case highlights the need to be aware of cytological characteristics of amyloidosis, which can have unusual presentation posing a diagnostic dilemma. 相似文献
87.
The National Institute of Child Health and Human Development held a workshop on September 12-13, 2005, to summarize the risks for adverse pregnancy outcomes after assisted reproductive technology (ART), develop an approach to counseling couples regarding these risks, and establish a research agenda. Although the majority of ART children are normal, there are concerns about the increased risk for adverse pregnancy outcomes. More than 30% of ART pregnancies are twins or higher-order multiple gestations (triplets or greater) and more than one half of all ART neonates are the products of multifetal gestations, with an attendant increase in prematurity complications. Assisted reproductive technology singleton pregnancies also demonstrate increased rates of perinatal complications-small for gestational age infants, preterm delivery, and perinatal mortality-as well as maternal complications, such as preeclampsia, gestational diabetes, placenta previa, placental abruption, and cesarean delivery. Although it is not possible to separate ART-related risks from those secondary to the underlying reproductive pathology, the overall increased frequency of obstetric complications, including preterm birth and small for gestational age neonates, should be discussed with the couple. Significant gaps in knowledge were identified, and the basic science and clinical and epidemiologic research required to address these gaps is outlined. 相似文献
88.
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90.
GBT440 increases haemoglobin oxygen affinity,reduces sickling and prolongs RBC half‐life in a murine model of sickle cell disease
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Donna Oksenberg Chihyuan Chuang Zhe Li Qing Xu Abel Silva‐Garcia Chengjing Zhou Athiwat Hutchaleelaha Larysa Patskovska Yury Patskovsky Steven C. Almo Uma Sinha Brian W. Metcalf David R. Archer 《British journal of haematology》2016,175(1):141-153
A major driver of the pathophysiology of sickle cell disease (SCD) is polymerization of deoxygenated haemoglobin S (HbS), which leads to sickling and destruction of red blood cells (RBCs) and end‐organ damage. Pharmacologically increasing the proportion of oxygenated HbS in RBCs may inhibit polymerization, prevent sickling and provide long term disease modification. We report that GBT440, a small molecule which binds to the N‐terminal α chain of Hb, increases HbS affinity for oxygen, delays in vitro HbS polymerization and prevents sickling of RBCs. Moreover, in a murine model of SCD, GBT440 extends the half‐life of RBCs, reduces reticulocyte counts and prevents ex vivo RBC sickling. Importantly, oral dosing of GBT440 in animals demonstrates suitability for once daily dosing in humans and a highly selective partitioning into RBCs, which is a key therapeutic safety attribute. Thus, GBT440 has the potential for clinical use as a disease‐modifying agent in sickle cell patients. 相似文献