A Review of Autism Spectrum Disorders (ASD) from A Perspective of Classical Chinese Medicine (CCM)

Introduction Autism is a complex developmental disability that typically appears during the first two years of man's life and is the result of a neurological disorder that affects the functioning of the brain,and the     

Peripheral blood stem cell donation: an analysis from the International Bone Marrow Transplant Registry (IBMTR) and European Group for Blood and Marrow Transplant (EBMT) databases

Donation-related data for 1488 allogeneic peripheral blood stem cell (PBSC) transplants reported to the International Bone Marrow Transplant Registry (IBMTR) or the European Blood and Marrow Transplant Group (EBMT) by 152 teams worldwide between 1994 and 1998 were reviewed. In 1998, 26% of allografts registered with the IBMTR were collected from blood. Median age of PBSC donors was 38 years (range <1-76), and 55% were male. Of 1486 donor-recipient pairs evaluable for HLA compatibility, 1322 (89%) were HLA-identical siblings. Recombinant human granulocyte colony-stimulating factor (G-CSF) was employed to mobilize PBSCs in almost all (99%) cases. One hundred and seventy (20%) of 828 evaluable PBSC donors had a central catheter placed for leukapheresis. Eighty-five percent of 1321 evaluable PBSC grafts were collected with one or two leukaphereses. There were 15 reported donation-related adverse events (1% of evaluable donors). Complications were catheter-related in five. No donation-related fatalities were reported. These data suggest that PBSC donation is becoming more prevalent worldwide. It appears to have a safety profile comparable to marrow harvesting, although experience with the latter is much more extensive.     

Hyperpolarization-activated Cyclic nucleotide-gated Channel and Cardiac Biological Pacemaker:Part Ⅰ

Hyperpolarization-activated cyclic-nucleotide-gated (HCN) channels in the heart modulate cardiac automaticity via the hyperpolarization-activated cation current ( named Ⅰf, Ⅰh, or Ⅰq). Recent studies have unveiled the molecular identity of HCN (HCN1-4) channels. HCN isoforms are unevenly expressed in the heart, even in the sinoatrial node. Features of HCN currents have been characterized in cardiac and other types of cells or in cell lines transfected with the HCN isoforms. The factors modulating Ih and the physiological significance of HCN channels in the heart have been extensively investigated in recent years. The hypothesis for transplanting and/or creating biological pacemakers to replace diseased sinoatrial and/or atrioventricular nodes has been postulated and tested in animal models. Local overexpression of HCN2 channels in the left atrium or in the left conductive bundle branch of the left ventricle via gene delivery induced significant Ⅰh and escape rhythms during vagal stimulation in canines. In addition, implantation of human mesenchymal stem cells with overexpression of HCN2 channels to the canine left ventricular wall was associated with formation of spontaneous escape rhythms of left-sided origin during vagal-stimulation-induced sinus arrest. This preliminary data suggest that the use of HCN channels may hold great promise in,the development of biological pacemakers.     

Resuscitation from Prolonged Ventricular Fibrillation by Epinephrine Combined with Sodium-Hydrogen Exchanger Isoform-1 Inhibitor Cariporide

Formorethan４０years，epinephrinehasbeenthevasopressoragentofchoiceforcardiopulmonaryresus－citation（CPR）andcurrentlyisstillbesuggestedbyAmericanHeartAssociationandwidelyuseinclinicCPR．However，recentstudiesquestionthevalueofepinephrineadministrationdu     

Attending rounds

To determine attitudes regarding attending rounds, the authors surveyed all internal medicine residents and attending physicians at the eight Army teaching hospitals. The response rate was 86%, including 166 (76%) of 217 residents and 246 (93%) of 264 attendings. Of 12 educational activities, attending rounds were randked seventh by residents in their perceived value. Both residents and attendings favored sessions that lasted 90 minutes or less and were held three to four times per week. Most respondents felt case presentations should take 5 minutes or less and be delivered away from the patient’s bedside. On average, residents preferred less time at the bedside than did attendings (25% vs. 34% of attending round time). Residents desired substantial control of the agenda for rounds and also wanted to be responsible for one-third of the teaching. The attending-physician attributes that residents valued most highly were fund of knowledge, availability, and relating well to housestaff. Since residents’ and attending physicians’ attitudes may differ, expectations regarding attending rounds should be clarified at the beginning of a ward rotation so that mutually acceptable goals can be established. Presented in part at the 12th Annual Meeting of the Society of General Internal Medicine, Washington, D.C., April 28, 1989.     

血吸虫病洲岛型疫区单纯化疗的防治成效考核

洲岛型日本血吸虫病重疫区,连续三年采用选择性人群化疗控制措施。以改良Kato法考核其防治效果,并用IHA检测抗体水平,结果表明:洲岛型疫区单纯选择性人群化疗难以阻挡血吸虫病传播,但可以降低流行率。     

美国针灸中医教育概况

针灸中医教育是中医事业的重要组成部分,通过对它的起源、发展、历史背景、针灸立法、针灸管理机构的探讨,可更好地了解美国的针灸和中医的现况.这对中国发展海外教育与合作、制定海外交流和发展策略有一定的参考价值,也为各国中医教育提供了信息平台.在过去的40年中,美国针灸教育经历了上世纪70年代的起步期,80年代的增长期,90年...