Palmar Purpura: An Atypical Presentation of Childhood Dermatitis Herpetiformis

Abstract: Dermatitis herpetiformis (DH) is seen most commonly as a pruritic, papulovesicular eruption in young children or adolescents. Differentiation from other bullous diseases of childhood may be difficult. We report the first case of an adolescent in whom pruritic, palmar, purpuric macules and papules were the only manifestations of DH. The patient later developed typical vesiculobullous extensor lesions and symptomatic gluten-sensitive enteropathy (GSE). All lesions and GSE symptoms resolved with dapsone and a gluten-free diet. Our purpose is to illustrate an unusual presentation of pediatric DH.     

乙型肝炎病毒X基因蛋白诱导人类白细胞抗原DR表达

乙型肝炎病毒(HBV)所致的肝细胞坏死,被认为是与人类白细胞抗原(HLA)有关的MHC限制的T细胞为主的免疫应答的结果。本研究证实,转染HBV基因组或X基因后的人肝癌细胞系可诱导HLAⅡ(即HLA DR)表达。核转录及RNA杂交分析提示表达X基因的细胞其HLA DR mRNA水平增加,X蛋白增加该基因的转录。氯霉索乙酰基转移酶(CAT)基因分析进一步提示,X蛋白通过作用于HLA DR基因上游的调节序列诱导HLA DR表达。结果表明:X蛋白可能通过调节HLA DR表达参与HBV感染的免疫发病机理。     

Dr. Wang Zhengguo received 1998 the Michael E. DeBakey International Military Surgeons Award

Dr. Wang Zhengguo, member of the editorial board of the Chinese Medical Journal, a noted military surgeon of the Research Institute of Surgery, the Third Military Medical University, Chongqing, China, received 1998 the Michael E. DeBakey International Military Surgeons Award on March 23, 1998 in Bethesda, Maryland, USA, in recognition of his many years of dedicated and valuable efforts in supporting the worldwide activities to improve military medicine and surgery.     

Arthrofibrosis: Etiology,classification, histopathology, and treatment

This article provides a complete review of arthrofibrosis following ACL reconstruction, and a complete review of theetiology, classification, and histology of arthrofibrosis. A clinician's guide to the recognition of arthrofibrosis and when the arthrofibrosis is clinically significant, treatment of arthrofibrosis after determination of arthrofibrosis, and its treatment to include surgical and nonsurgical management is noted. We emphasize prevention with appropriate indications and timing of ACL reconstruction and appropriate intraoperative surgical techniques for a correctly performed ACL reconstruction. The appropriate rehabilitation and expected clinical progress and parameters to follow after ACL reconstruction with emphasis on early recognition and early treatment will significantly improve the outcome of treatment of clinically significant arthrofibrosis and hopeful prevention of arthrofibrosis. By applying the techniques reviewed, prevention of arthrofibrosis is the orthopaedic surgeons best weapon.     

Immunohistochemical investigation of voltage-gated potassium channel-interacting protein 1 in normal rat brain and Pentylenettrazole-induced seizures

1 Introduction To discover accessory subunit of the Kv4 A-type channel, three novel proteins termed Kv channel-interact- ing proteins were identified as KChIP1, KChIP2, and KChIP3, and another homologue KChIP4 was found latterly. These novel proteins turn out to have around 40% amino-acid similarity to neuronal calcium sensor-1 (NCS-1) and belong to neuronal calcium sensor (NCS) family, which consists of those EF-hand-containing Ca2 -binding pro- teins that express predominantly or …     

China’s great wall,Israel’s Bar Lev Line,and passive infectious disease surveillance

Emerging infectious diseases are some of modern society’s greatest threats. Like some great construction efforts designed to protect mankind, current public health measures against these emerging pathogens have not always been successful. This paper highlights the importance of embracing new interdisciplinary approaches towards emerging pathogen threats. One such approach, termed One Health, is quickly being embraced by professional organizations and public health institutions across the world as a way forward. This paper briefly discusses the above problems and preliminary steps taken by Chinese academic institutions to embrace the One Health approach.