芳香基硼氨配合物AsCl_2NMesBMes_2的合成与结构测定

合成了芳香基硼氨配合物MesNHBMes_2及其As的衍生物AsCl_2NMesBMes_2(Mes=Me_3C_6H_2-),并通过X线衍射进行了结构测定。结果表明,带有配体的N-B中心呈平面形,平面间扭曲的角度一般小于10°,B-N原子之间多重键的性质无改变。用M_0K_a(λ=0.0071069nm)在130K低温下X线衍射所得的晶体数据为:1.MesNHBMes_2,C_(27)H_(34)BN,a=0.8200(1)nm,b=1.0370(3)nm,C=1.5134(3)nm,α=109.38(2)°,β=80.96(2)°,γ=108.71(2)°,三斜晶体,空间群p(?),R=0.063。2.AsCl_2NMesBMes_2,C_(27)H_(33)AsBCl_2N,a=2.2681(3)nm,b=8.3510(9)nm,C=2.7961(3)nm,β=98.80(1)°,单斜晶体,空间群P2_(1/a)。     

Simultaneous esophageal pH monitoring and scintigraphy during the postprandial period in patients with severe reflux esophagitis

To compare reflux events detected by intraesophageal pH monitoring with that of scintigraphy, we simultaneously performed both techniques along with esophageal manometry in nine patients with severe reflux esophagitis. Two hundred eighteen reflux events were detected in the recumbent posture after a meal during a 40-min interval. Both techniques simultaneously detected only 23% of all reflux events. Scintigraphy alone detected 61% of all reflux events as opposed to 16% for pH monitoring. Of those reflux events diagnosed only by scintigraphy, more occurred while the intraesophageal pH was less than 4 (ie, during an acid-clearing interval) than while the intraesophageal pH was greater than 4 (ie, when intragastric contents were neutralized by the meal). Most reflux events occurred during periods of stable, but low LES pressure. While reflux events diagnosed by scintigraphy significantly decreased during the second of two 20-min postprandial intervals, those by pH monitoring tended to increase. That simultaneous scintigraphy and pH monitoring agreed on less than 1/3 of all reflux events not only underscores the fact that both techniques measured different physical components of the esophageal refluxate (ie, volume vs acid concentration, respectively), but also were influenced by different physiologic events such as the ingestion of a meal, gastric emptying, and esophageal acid clearance.     

国际生命伦理学和伦理的相对性

该文详尽论述了“伦理相对性”（即基于不同的文化支撑而不同的伦理观），“文化多元性”的内容及动作程序，并对其与生命伦理学研究的关系阐释的独到的见解。     

生物活化黄曲霉毒素对病毒干扰素诱生的抑制作用

用鼠肝匀浆(S_9)代谢活化黄曲霉毒素B族和G族,研究它们对流感病毒在恒河猴肾细胞(LLC-MK_2)诱导干扰素-α/β的抑制作用。结果显示活化与未活化的黄曲霉毒素对干扰素诱生都有抑制作用。但代谢活化后,抑制作用增强,抑制作用的大小按B_1>G_1>B_2>G_2顺序排列,显示有结构-活性关系。而干扰素赋予细胞的抗病毒能力并不受黄曲霉毒素的影响。     

Coronary artery disease in aortic surgery

The incidence of coronary artery disease in patients coming to aortic surgery and the impact of aggressive preoperative cardiac catheterization and myocardial revascularization was prospectively analyzed in 59 patients. Seventy-five percent of patients had at least one-vessel involvement, and 32% had three-vessel or left main involvement. Patients with electrocardiographic evidence of coronary artery disease had at least one-vessel involvement 84% of the time and three-vessel, left main involvement 36% of the time. Sixty-four percent of patients with no preoperative indications of coronary artery disease had at least one-vessel involvement and 29% had three-vessel, left main involvement. Resting (39 patients) and exercise multiple-gated acquisition scans (22 patients) did not predict the presence of coronary artery disease in patients without a history or electrocardiographic evidence of coronary artery disease. Myocardial revascularization was performed prior to aortic surgery in 17 patients (29%). The operative mortality was 3.7% with two patients dying from noncardiac-related complications. There were two additional deaths prior to aortic surgery with one patient dying during coronary artery bypass grafting, and one dying of aneurysm rupture prior to repair, making the overall mortality associated with this approach 7.4%. Preoperative cardiac catheterization and an aggressive approach toward coronary artery bypass grafting reduces the risk of cardiac complications in aortic surgery.     

大鼠膀胱泛素样分子的分离纯化及其N-端氨基酸序列分析

作者用醋酸冲洗膀胱粘膜,所得冲洗液经反相高压液相层析纯化出泛素样分子,N-端部分氨基酸序列测定显示其N-端25个氨基酸序列与人泛素一致。结合粘膜上皮抗菌多肽分子的发现,作者由此提出粘膜上皮也可能是一类免疫细胞的新见解。