全文获取类型
收费全文 | 1167篇 |
免费 | 444篇 |
国内免费 | 4篇 |
专业分类
耳鼻咽喉 | 19篇 |
儿科学 | 40篇 |
妇产科学 | 20篇 |
基础医学 | 170篇 |
口腔科学 | 38篇 |
临床医学 | 135篇 |
内科学 | 387篇 |
皮肤病学 | 32篇 |
神经病学 | 118篇 |
特种医学 | 8篇 |
外科学 | 282篇 |
综合类 | 9篇 |
预防医学 | 48篇 |
眼科学 | 9篇 |
药学 | 150篇 |
中国医学 | 13篇 |
肿瘤学 | 137篇 |
出版年
2023年 | 2篇 |
2022年 | 11篇 |
2021年 | 30篇 |
2020年 | 83篇 |
2019年 | 138篇 |
2018年 | 108篇 |
2017年 | 113篇 |
2016年 | 126篇 |
2015年 | 112篇 |
2014年 | 124篇 |
2013年 | 149篇 |
2012年 | 74篇 |
2011年 | 71篇 |
2010年 | 119篇 |
2009年 | 74篇 |
2008年 | 53篇 |
2007年 | 26篇 |
2006年 | 35篇 |
2005年 | 24篇 |
2004年 | 29篇 |
2003年 | 30篇 |
2002年 | 28篇 |
2001年 | 10篇 |
2000年 | 14篇 |
1999年 | 7篇 |
1998年 | 6篇 |
1997年 | 4篇 |
1996年 | 3篇 |
1995年 | 1篇 |
1994年 | 1篇 |
1991年 | 1篇 |
1990年 | 1篇 |
1988年 | 1篇 |
1987年 | 2篇 |
1985年 | 2篇 |
1984年 | 1篇 |
1978年 | 1篇 |
1976年 | 1篇 |
排序方式: 共有1615条查询结果,搜索用时 500 毫秒
81.
Nationwide epidemiology and prognosis of dialysis‐requiring acute kidney injury (NEP‐AKI‐D) study: Design and methods
下载免费PDF全文
![点击此处可从《Nephrology (Carlton, Vic.)》网站下载免费的PDF全文](/ch/ext_images/free.gif)
Chih‐Chung Shiao Pei‐Chen Wu Vin‐Cent Wu Jui‐Hsiang Lin Heng‐Chih Pan Ya‐Fei Yang Tai‐Shuan Lai Tao‐Min Huang Che‐Hsiung Wu Wei‐Shun Yang Chih‐Jen Wu Chih‐Chin Kao Chiao‐Yin Sun Chun‐Te Huang Kuo‐Hua Lee Chan‐Yu Lin Te‐Chuan Chen Fu‐Chang Hu Hung‐Hsiang Liou Kuo‐Cheng Lu Kuo‐Liong Chien Jian‐Jhong Wang Wei‐Chih Kan Feng‐Chi Kuo Hugo You‐Hsien Lin Cheng‐Min Chen Zi‐hong You Jen‐Pi Tsai Chih‐Jen Weng Hung‐Yuan Chen Chao‐Fu Chang Wen‐Ding Hsu Mai‐Szu Wu Chiu‐Ching Huang Kwan‐Dun Wu 《Nephrology (Carlton, Vic.)》2016,21(9):758-764
82.
Chun‐Chih Chen Ying‐Tzu Lin 《The International journal of health planning and management》2018,33(2):321-328
Chronic diseases, also known as non‐communicable diseases (NCDs), have become the leading causes of deaths and disability around the world. Cardiovascular disease, cancer, and diabetes are also listed in the top 10 causes of deaths in Taiwan for decades. This study aims to investigate the relationship the chronic diseases and the mid‐age employment in Taiwan. We estimate the impact of the chronic diseases on employment using the 2009 NHIS data of Taiwan using 2 kinds of probit model. In addition, we show that a usual probit model can underestimate the negative effect of NCDs on mid‐age employment. To reduce the productivity loss from the NCDs, policymakers can increase the awareness of risk of these chronic diseases through media and the adult preventive care services, which is free for the people aged 40 and above in Taiwan. 相似文献
83.
Chou CC Cardoso Eda S Chan F Tsang HW Wu M 《International journal of rehabilitation research. Internationale Zeitschrift für Rehabilitationsforschung. Revue internationale de recherches de réadaptation》2007,30(4):261-271
The aim of this study was to validate a Task-Specific Self-Efficacy Scale for Chinese people with mental illness. The study included 79 men and 77 women with chronic mental illness. The Task-Specific Self-Efficacy Scale for People with Mental Illness (TSSES-PMI) and Change Assessment Questionnaire for People with Severe and Persistent Mental Illness were used as measures for the study. Factor analysis of the TSSES-PMI resulted in four subscales: Symptom Management Skills, Work-Related Skills, Help-Seeking Skills, and Self-Emotional-Regulation Skills. These community living skills were found to be related to the level of readiness for psychiatric rehabilitation among Chinese people with mental illness. In conclusion the results support the construct validity of the TSSES-PMI for the Chinese population and the TSSES-PMI can be a useful instrument for working with Chinese people with mental illnesses. 相似文献
84.
Aws Almufleh Liyong Zhang Lisa M. Mielniczuk Ellamae Stadnick Ross A. Davies Qiujiang Du Katey Rayner Peter P. Liu Sharon Chih 《Clinical transplantation》2020,34(1):e13765
Cardiac allograft vasculopathy (CAV) limits long-term survival after heart transplantation. Non-invasive evaluation is challenging, and currently, there is no validated biomarker for CAV diagnosis or prognostication. To identify potential candidate CAV biomarkers, we utilized the Slow Off-rate Modified Aptamer (SOMAscan) assay, which evaluates over 1000 serum proteins, including many relevant to biological pathways in CAV. We evaluated three heart transplant patient groups according to angiographic ISHLT CAV grade: CAV1-2 (mild-moderate CAV), CAV3 (severe CAV), and CAV0 (normal control). SOMAscan assays were performed and proteins quantitated. Comparisons of proteins between study groups were performed using one-way ANOVA (false discovery rate q-value < 0.10). Thirty-one patients (12 mild-moderate CAV, 9 severe CAV, 10 controls) were included: 81% male, median age 57 years and median 1.1 years post-transplant. Compared to controls, patients with mild-moderate CAV had similar characteristics, while patients with severe CAV had longer time from transplant and increased allosensitization. Statistical/bioinformatics analysis identified 14 novel biomarkers for CAV, including 4 specific for mild-moderate CAV. These proteins demonstrated important actions including apoptosis, inflammation, and platelet/coagulation activation. Upon preliminary receiver operating characteristics curve analysis, our protein biomarkers showed moderate-to-high discriminative ability for CAV (area under curve: 0.72 to 0.94). These candidate biomarkers are being validated in prospective studies. 相似文献
85.
Erik Loewen Friesen Farid Foroutan John Krakovsky Sharon Chih Heather Ross Filio Billia Vivek Rao Ana Carolina Alba 《Clinical transplantation》2020,34(3):e13796
The Interagency Registry of Mechanically Assisted Circulatory Support (INTERMACS) profiles are associated with mortality in heart failure patients undergoing ventricular assist device (VAD) implantation and heart transplantation (HTx). We assessed the prognostic value of the INTERMACS profile at the time of assessment for HTx or durable VAD implantation as bridge to candidacy (BTC). A total of 503 consecutive patients considered for HTx or VAD between 2006 and 2016 were included. The associations between INTERMACS profile and (a) waitlist mortality or delisting, (b) probability of HTx, and (c) overall mortality or delisting were evaluated using multivariable analysis. Median follow-up time was 2.9 years (IQR: 0.9-5.5) during which 184 received VAD, 347 received HTx, and 73 died (27 waitlist, 46 post-transplant). INTERMACS I-II profile was associated with higher waitlist mortality or delisting (HR: 3.83, 95% CI: 1.22-12.03), and this risk was reversed by VAD implantation (HR: 0.12, 95% CI: 0.03-0.50). INTERMACS III-IV profile was associated with a higher probability of HTx (HR: 1.82, 95% CI: 1.37-2.40). INTERMACS profile was not associated with the composite outcome of overall mortality or delisting. These results emphasize the prognostic utility of INTERMACS at time of decision for advanced therapies and its potential value in selecting patients for different interventions. 相似文献
86.
87.
Yi‐Shih Ma Shu‐Chun Hsu Shu‐Wen Weng Chien‐Chih Yu Jai‐Sing Yang Kuang‐Chi Lai Jing‐Pin Lin Jaung‐Geng Lin Jing‐Gung Chung 《Environmental toxicology》2014,29(9):969-980
Crude extract of Rheum palmatum L (CERP) has been used to treat different diseases in the Chinese population for decades. In this study, we investigated the effects of CERP on LS1034 human colorectal cancer cells in vitro and also examined possible mechanisms of cell death. Flow cytometric assays were used to measure the percentage of viable cells, cell cycle distribution including the sub‐G1 phase (apoptosis), the activities of caspase‐8, ‐9, and ‐3, reactive oxygen species (ROS) and Ca2+ levels, and mitochondrial membrane potential (ΔΨm). DNA damage, nuclei condensation, protein expression, and translocation were examined by Comet assay, 4′‐6‐diamidino‐2‐phenylindole (DAPI) staining, Western blotting, and confocal laser system microscope, respectively. CERP induced apoptosis as seen by DNA fragmentation and DAPI staining in a concentration‐ and time‐dependent manner in cancer cells. CERP was associated with an increase in the Bax/Bcl‐2 protein ratio and CERP promoted the activities of caspase‐8, ‐9, and ‐3. Both ROS and Ca2+ levels were increased by CERP but the compound decreased levels of ΔΨm in LS1034 cells. Laser confocal microscope also confirmed that CERP promoted the expressions of AIF, Endo G, cytochrome c, and GADD153 to induce apoptosis through mitochondrial‐dependent pathway. © 2013 Wiley Periodicals, Inc. Environ Toxicol 29: 969–980, 2014. 相似文献
88.
89.
Szu‐Chun Hung Ko‐Lin Kuo Der‐Cherng Tarng Chih‐Cheng Hsu Mai‐Szu Wu Tung‐Po Huang 《Nephrology (Carlton, Vic.)》2014,19(12):735-739
The introduction of erythropoiesis‐stimulating agents (ESAs) markedly improved the lives of many anaemic patients with chronic kidney disease (CKD). In Taiwan, the strategy of management of anaemia in patients with CKD was different from many other parts of the world. In 1996, the National Health Insurance Administration of Taiwan applied a more restrictive reimbursement criteria for ESA use in patients with CKD. ESA is to be initiated when non‐dialysis CKD patients have a serum creatinine >6 mg/dL and a hematocrit <28% to maintain a hematocrit level not exceeding 30%. The maximal dose of epoetin‐α or β was 20 000 U per month. The target haemoglobin range and dose limitation for ESAs were the same for dialysis CKD patients. Thus, long before randomized controlled trials showing an increased risk for cardiovascular events at nearly normal haemoglobin concentrations and higher ESA doses in CKD, nephrologists in Taiwan had avoided the use of disproportionately high dosages of ESAs to achieve a haemoglobin level of 10–11 g/dL. Moreover, intravenous iron supplementation was encouraged earlier in Taiwan in 1996, when we reached consensus on the diagnostic criteria for iron deficiency (serum ferritin <300 ng/mL and/or transferrin saturation <30%). The experience of CKD anaemia management in Taiwan demonstrated that a reasonable haemoglobin target can be achieved by using the lowest possible ESA dose and intravenous iron supplementation. 相似文献
90.