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71.
72.
Hao Lun Luo MD Chih Hsiung Kang MD Yen Ta Chen MD Yao Chi Chuang MD Wei Ching Lee MD Yuan Tso Cheng MD Po Hui Chiang PhD MD 《Annals of surgical oncology》2013,20(9):3121-3126
Background
Little is known about the effects of diagnostic ureteroscopy on intravesical recurrence after nephroureterectomy.Methods
This study was designed to determine the effect of diagnostic ureteroscopy on intravesical recurrence after nephroureterectomy. From 2004 to 2010, 446 patients underwent nephroureterectomy for upper urinary tract cancer at our tertiary medical center. We included 115 patients who underwent preoperative diagnostic ureteroscopy and 281 patients who did not. This study analyzed the impact of the reported risk factors and diagnostic ureteroscopy for intravesical recurrence after nephroureterectomy by multivariate Cox regression model.Results
The rates of metastasis and cancer-specific mortality did not differ significantly between the two groups. Diagnostic ureteroscopy was associated with a higher incidence of intravesical recurrence in patients with (p = 0.02) and without (p = 0.016) a previous history of bladder cancer. Ureter tumor biopsy (p = 0.272) and ureter involvement (p = 0.743) were not associated with the rate of intravesical recurrence in this study. Multivariate Cox regression analysis showed that only bladder cancer history (p < 0.001), multifocal tumor (p = 0.05), and diagnostic ureteroscopy (p = 0.05) were independently associated with intravesical recurrence.Conclusions
Diagnostic ureteroscopy for upper urinary tract cancer was not associated with metastasis and cancer-specific mortality. However, ureteroscopy was associated with an increased incidence of intravesical tumor recurrence. Methods of prevention should be considered to decrease intravesical recurrence and avoid repeated surgical interventions or the development of advanced bladder disease in patients at risk. 相似文献73.
No evidence based management guidelines exist for antibody mediated rejection (AMR) in heart transplantation. The International Society for Heart and Lung Transplantation (ISHLT) recently introduced standardized pathologic based diagnostic criteria for AMR (pAMR 0–3). We evaluated international practice for the management of AMR focusing on pAMR grade, donor specific antibody (DSA) and allograft function. On‐line survey data were analyzed from 184 ISHLT members (physicians‐78%, surgeons‐20%). The majority were from adult‐transplant (84%), medium‐large volume centres (transplants/year: 10–25, 61%; 25–50, 19%) across North America (60%) and Europe (26%). Irrespective of pAMR grade and DSA, 83–90% treated a drop in ejection fraction (EF ≤45% or >25% decrease). In the presence of stable EF, an increasing number elected treatment for progressively severe pAMR grade (p < 0.001) and for accompanying DSA (p < 0.05, pAMR 1–3). Intravenous steroid was the most commonly used therapy followed by intravenous immunoglobulin (IVIG) or plasmapheresis, rituximab and thymoglobulin. Plasmapheresis and rituximab were favored for positive versus negative DSA (p < 0.05). Using a threshold of ≥70% consensus among respondents, treatment for AMR may be considered for a drop in EF, asymptomatic pAMR 3 or asymptomatic pAMR 2 with DSA. Combination steroid, IVIG and plasmapheresis are suggested as initial therapies. 相似文献
74.
Chih‐Cheng Huang MD PhD Tai‐Lin Huang MD Hsuan‐Chih Hsu MD Hui‐Chun Chen MD Hsin‐Ching Lin MD Chih‐Yen Chien MD Fu‐Min Fang MD PhD Hsueh‐Wen Chang PhD Nai‐Wen Tsai MD PhD Wen‐Neng Chang MD Shu‐Fang Chen MD Tzu‐Kong Lin MD PhD Teng‐Yeow Tan MD Chuang‐Rung Chang PhD Hung‐Chen Wang MD Wei‐Che Lin MD PhD Cheng‐Hsien Lu MD MSc 《Muscle & nerve》2013,47(3):344-350
75.
Tzu‐Yu Lin Chih‐Yang Chung Cheng‐Wei Lu Shu‐Kuei Huang Jiann‐Sing Shieh Su‐Jane Wang 《Synapse (New York, N.Y.)》2013,67(9):568-579
Local anesthetics have been widely used for regional anesthesia and the treatment of cardiac arrhythmias. Recent studies have also demonstrated that low‐dose systemic local anesthetic infusion has neuroprotective properties. Considering the fact that excessive glutamate release can cause neuronal excitotoxicity, we investigated whether local anesthetics might influence glutamate release from rat cerebral cortex nerve terminals (synaptosomes). Results showed that two commonly used local anesthetics, lidocaine and bupivacaine, exhibited a dose‐dependent inhibition of 4‐AP‐evoked release of glutamate. The effects of lidocaine or bupivacaine on the evoked glutamate release were prevented by the chelation of extracellular Ca2+ ions and the vesicular transporter inhibitor bafilomycin A1. However, the glutamate transporter inhibitor dl ‐threo‐beta‐benzyl‐oxyaspartate did not have any effect on the action of lidocaine or bupivacaine. Both lidocaine and bupivacaine reduced the depolarization‐induced increase in [Ca2+]C but did not alter 4‐AP‐mediated depolarization. Furthermore, the inhibitory effect of lidocaine or bupivacaine on evoked glutamate release was prevented by blocking the Cav2.2 (N‐type) and Cav2.1 (P/Q‐type) channels, but it was not affected by blocking of the ryanodine receptors or the mitochondrial Na+/Ca2+ exchange. Inhibition of protein kinase C (PKC) and protein kinase A (PKA) also prevented the action of lidocaine or bupivacaine. These results show that local anesthetics inhibit glutamate release from rat cortical nerve terminals. This effect is linked to a decrease in [Ca2+]C caused by Ca2+ entry through presynaptic voltage‐dependent Ca2+ channels and the suppression of the PKA and PKC signaling cascades. Synapse 67:568–579, 2013 . © 2013 Wiley Periodicals, Inc. 相似文献
76.
Biallelic AOPEP Loss-of-Function Variants Cause Progressive Dystonia with Prominent Limb Involvement
Michael Zech MD Kishore R. Kumar MBBS PhD FRACP Sophie Reining MD Janine Reunert PhD Michel Tchan MBBS PhD FRACP Lisa G. Riley PhD Alexander P. Drew PhD Robert J. Adam MA MBBS PhD FRACP FRCP Riccardo Berutti PhD Saskia Biskup MD Nicolas Derive PhD Somayeh Bakhtiari PhD Sheng Chih Jin PhD Michael C. Kruer MD Tanya Bardakjian MS Pedro Gonzalez-Alegre MD PhD Ignacio J. Keller Sarmiento MD Niccolo E. Mencacci MD PhD Steven J. Lubbe PhD Manju A. Kurian PhD Fabienne Clot PhD Aurélie Méneret MD PhD Jean-Madeleine de Sainte Agathe MD Victor S.C. Fung MBBS PhD FRACP Marie Vidailhet MD Matthias Baumann MD Thorsten Marquardt MD Juliane Winkelmann MD Sylvia Boesch MD 《Movement disorders》2022,37(1):137-147
77.
Effect of radial shock wave therapy for carpal tunnel syndrome: A prospective randomized,double‐blind,placebo‐controlled trial
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Yung‐Tsan Wu Ming‐Jen Ke Yu‐Ching Chou Chih‐Ya Chang Ching‐Yueh Lin Tsung‐Ying Li Feng‐Mei Shih Liang‐Cheng Chen 《Journal of orthopaedic research》2016,34(6):977-984
Three recent studies demonstrated the positive effect of extracorporeal shock wave therapy (ESWT) for treating carpal tunnel syndrome (CTS). However, none have entirely proved the effects of ESWT on CTS because all studies had a small sample size and lacked a placebo‐controlled design. Moreover, radial ESWT (rESWT) has not been used to treat CTS. We conducted a prospective randomized, controlled, double‐blinded study to assess the effect of rESWT for treating CTS. Thirty‐four enrolled patients (40 wrists) were randomized into intervention and control groups (20 wrists in each). Participants in the intervention group underwent three sessions of rESWT with nightly splinting, whereas those in the control group underwent sham rESWT with nightly splinting. The primary outcome was visual analog scale (VAS), whereas the secondary outcomes included the Boston Carpal Tunnel Syndrome Questionnaire (BCTQ), cross‐sectional area (CSA) of the median nerve, sensory nerve conduction velocity of the median nerve, and finger pinch strength. Evaluations were performed before treatment and at 1, 4, 8, and 12 weeks after the third rESWT session. A significantly greater improvement in the VAS, BCTQ scores, and CSA of the median nerve was noted in the intervention group throughout the study as compared to the control group (except for BCTQ severity at week 12 and CSA at weeks 1 and 4) (p < 0.05). This is the first study to assess rESWT in a randomized placebo‐controlled trial and demonstrate that rESWT is a safe and effective method for relieving pain and disability in patients with CTS. © 2015 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 34:977–984, 2016. 相似文献
78.
79.
Osteoradionecrosis of mandible bone in patients with oral cancer—associated factors and treatment outcomes
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80.