全文获取类型
收费全文 | 7091篇 |
免费 | 372篇 |
国内免费 | 76篇 |
专业分类
耳鼻咽喉 | 28篇 |
儿科学 | 141篇 |
妇产科学 | 133篇 |
基础医学 | 1071篇 |
口腔科学 | 161篇 |
临床医学 | 425篇 |
内科学 | 1741篇 |
皮肤病学 | 252篇 |
神经病学 | 601篇 |
特种医学 | 250篇 |
外科学 | 1074篇 |
综合类 | 23篇 |
预防医学 | 178篇 |
眼科学 | 73篇 |
药学 | 515篇 |
中国医学 | 18篇 |
肿瘤学 | 855篇 |
出版年
2023年 | 27篇 |
2022年 | 89篇 |
2021年 | 148篇 |
2020年 | 76篇 |
2019年 | 102篇 |
2018年 | 149篇 |
2017年 | 158篇 |
2016年 | 169篇 |
2015年 | 170篇 |
2014年 | 242篇 |
2013年 | 279篇 |
2012年 | 468篇 |
2011年 | 518篇 |
2010年 | 305篇 |
2009年 | 243篇 |
2008年 | 425篇 |
2007年 | 501篇 |
2006年 | 490篇 |
2005年 | 488篇 |
2004年 | 482篇 |
2003年 | 502篇 |
2002年 | 475篇 |
2001年 | 74篇 |
2000年 | 55篇 |
1999年 | 91篇 |
1998年 | 123篇 |
1997年 | 81篇 |
1996年 | 69篇 |
1995年 | 73篇 |
1994年 | 65篇 |
1993年 | 53篇 |
1992年 | 42篇 |
1991年 | 39篇 |
1990年 | 36篇 |
1989年 | 41篇 |
1988年 | 19篇 |
1987年 | 22篇 |
1986年 | 10篇 |
1985年 | 14篇 |
1984年 | 13篇 |
1983年 | 7篇 |
1982年 | 18篇 |
1981年 | 9篇 |
1980年 | 12篇 |
1979年 | 13篇 |
1978年 | 8篇 |
1977年 | 7篇 |
1976年 | 7篇 |
1973年 | 7篇 |
1969年 | 5篇 |
排序方式: 共有7539条查询结果,搜索用时 62 毫秒
101.
Takuya HASEGAWA Chiyoe MURATA Takashi NINOMIYA Tomoko TAKABAYASHI Tatsuya NODA Shinya HAYASAKA Mieko NAKAMURA Toshiyuki OJIMA 《Industrial health》2013,51(5):490-500
Problem drinking is a serious public health problem in the workplace. However, few
Japanese epidemiological studies have investigated the occupational characteristics of
problem drinking. The purpose of this study is to clarify the occupational risk factors
for problem drinking among a Japanese working population. We used data from a
random-sampling survey about mental health and suicide, conducted among Hamamatsu City
residents aged 15 to 79 yr old during May and June in 2008. The relation between
occupational factors and problem drinking was analyzed with multiple logistic regression
models stratified by gender. CAGE questionnaire was used to assess problem drinking. With
regard to employment types, problem drinkers were more prevalent among self-employed
women. With regard to occupational types, clerical and service professions had more
problem drinkers of either sex, while administrative/managerial and sales professions had
more women with such problem. With regard to company size, male problem drinkers were more
prevalent in smaller companies than in larger ones. These results indicate that the
prevalence of problem drinkers in the workplace depends on where one works. It is
necessary to consider these characteristics to provide effective measures to address
problem drinking in the workplace. 相似文献
102.
103.
104.
105.
Neonatal lupus erythematosus (LE) is a rare immune-mediated disease caused by placental transport of maternal anti-SSA/Ro, anti-SSB/La and/or anti-U1RNP antibodies. Here, we demonstrate two cases of neonatal LE, in both of which cutaneous LE was exacerbated by inoculation. To our knowledge, cases worsening neonatal LE after administration of vaccines have not been reported. In case 1, not only exacerbation of pre-existing annular erythema but also spreading of new erythematous lesions to the trunk and extremities were induced following vaccination. Of interest, all of the lesions simultaneously improved. By contrast, in case 2, pre-existing facial erythema became prominent without spreading to other sites. The mother of case 1 had Sjögren’s syndrome, whereas in case 2, the mother was diagnosed with Sjögren’s syndrome on this occasion for the first time. Immunohistochemistry in case 1 revealed interleukin (IL)-17-positive cells infiltrating into the papillary dermis, and CD123-positive plasmacytoid dendritic cells in the papillary dermis and the deep reticular dermis. Both innate immune response and IL-17 mediated inflammation following vaccination are speculated as a possible mechanism of the deterioration of LE lesions in our juvenile cases. Caution is necessary since neonatal LE can be worsened following vaccination. 相似文献
106.
Junya Sakamoto Yoshitaka Manabe Joichi Oyamada Hideki Kataoka Jiro Nakano Kazunobu Saiki Keishi Okamoto Toshiyuki Tsurumoto Minoru Okita 《Clinical anatomy (New York, N.Y.)》2018,31(5):705-709
Introduction : Referred pain in the anterior knee joint is the most common symptom in hip disease patients. The development of referred pain is considered to be related to dichotomizing peripheral sensory fibers. However, no gross anatomical findings identify any dichotomizing fibers innervating both the hip and knee joints. We dissected the femoral and obturator nerves in human cadavers to investigate the distribution of the articular branches in the hip and knee joints. Fourteen embalmed left lower limbs from 14 Japanese adult cadavers (five from females, nine from males, average age 73.8 ± 14.1 years) were observed macroscopically. The articular branches of the femoral and obturator nerves were dissected at the anterior margin of the groin toward the thigh region. After dissections of the articular nerves of the hip joints, the femoral and obturator nerves were exposed from proximally to distally to identify the articular nerves of the knee joints. The branching pattern of the articular branches in the hip and knee joints was recorded. In six of 14 limbs (42.9%), the femoral nerve supplied articular branches to the anteromedial aspect of both the hip and knee joints. These articular branches were derived from the same bundle of femoral nerve. These gross anatomical findings suggested that dichotomizing peripheral sensory fibers innervate the hip and knee joints and these could relate to the referred pain confirmed in the anterior knee joints of patients with hip disease. Clin. Anat. 31:705–709, 2018. © 2018 Wiley Periodicals, Inc. 相似文献
107.
108.
Mai Shimura Hiroshi Ishikawa Hiromi Nagase Akihiko Mochizuki Futoshi Sekiguchi Naho Koshimizu Toshiyuki Itai Mizuha Odagami 《Congenital anomalies》2018,58(5):167-170
We investigated whether it was possible to predict the prognosis of fetuses with cystic hygroma in early pregnancy based on the degree of neck thickening. We retrospectively analyzed 57 singleton pregnancies with fetuses with cystic hygroma who were examined before the 22nd week of pregnancy. The fetuses were categorized according to the outcome, structural abnormalities at birth, and chromosomal abnormalities. Here, we proposed a new sonographic predictor with which we assessed neck thickening by dividing the width of the neck thickening by the biparietal diameter, which is expressed as the cystic hygroma width/biparietal diameter ratio. The median cystic hygroma width/biparietal diameter ratio in the intrauterine fetal death group (0.51) was significantly higher than that in the live birth group (0.27). No significant difference in the median cystic hygroma width/biparietal diameter ratio was found between the structural abnormalities group at birth and the no structural abnormalities group, and no significant difference in the median cystic hygroma width/biparietal diameter ratio was found between the chromosomal abnormality group and the no chromosomal abnormality group. We used receiver operating characteristic analysis to evaluate the cystic hygroma width/biparietal diameter ratio to predict intrauterine fetal death. When the cystic hygroma width/biparietal diameter ratio cut‐off value was 0.5, intrauterine fetal death could be predicted with a sensitivity of 52.9% and a specificity of 100%. It is possible to predict intrauterine fetal death in fetuses with cystic hygroma in early pregnancy if cystic hygroma width/biparietal diameter ratio is measured. However, even if cystic hygroma width/biparietal diameter ratio is measured, predicting the presence or absence of a structural abnormality at birth or a chromosomal abnormality is difficult. 相似文献
109.
Possible genes responsible for developmental delay observed in patients with rare 2q23q24 microdeletion syndrome: Literature review and description of an additional patient
下载免费PDF全文
![点击此处可从《Congenital anomalies》网站下载免费的PDF全文](/ch/ext_images/free.gif)
Cases of 2q23q24 microdeletion syndrome are rare. Patients with chromosomal deletions in this region often show language impairment and/or developmental delay of variable severity. Previous genotype–phenotype correlation study suggested GALNT13 and KCNJ3 as possible candidate genes for such phenotypes. We identified a new overlapping deletion in a patient with severe developmental delay. The identified deletion extended toward the distal 2q24.1 region, and more severe phenotypes in the present patient were considered to be related to the additionally deleted genes including NR4A2 and GPD2. Previously reported chromosomal translocation and the mutation identified in GPD2 suggested that this gene would be responsible for the developmental delay. Re‐evaluation for the critical region for behavior abnormalities commonly observed in the patients with overlapping deletions of this region suggested that KCNJ3 rather than GALNT13 may be responsible for abnormal behaviors, although there was phenotypic variability. Combinatory deletions involving KCNJ3 and GPD2 may lead to more severe developmental delay. Further studies would be necessary to establish clearer genotype–phenotype correlation in patients with 2q23q24 microdeletion syndrome. 相似文献
110.
Propensity score‐matched study of laparoscopic and open surgery for colorectal cancer in rural hospitals
下载免费PDF全文
![点击此处可从《Journal of gastroenterology and hepatology》网站下载免费的PDF全文](/ch/ext_images/free.gif)
Toshihiro Nakao Mitsuo Shimada Kozo Yoshikawa Jun Higashijima Takuya Tokunaga Masaaki Nishi Chie Takasu Hideya Kashihara Ichio Suzuka Takashi Nishizaki Hiroshi Okitsu Toshiyuki Yagi Hidenori Miyake Murato Miura Mitsutoshi Fukuyama Daisuke Wada Yoshiaki Bando 《Journal of gastroenterology and hepatology》2016,31(10):1700-1704