全文获取类型
收费全文 | 3146篇 |
免费 | 157篇 |
国内免费 | 20篇 |
专业分类
耳鼻咽喉 | 23篇 |
儿科学 | 31篇 |
妇产科学 | 42篇 |
基础医学 | 310篇 |
口腔科学 | 94篇 |
临床医学 | 283篇 |
内科学 | 751篇 |
皮肤病学 | 48篇 |
神经病学 | 295篇 |
特种医学 | 77篇 |
外科学 | 524篇 |
综合类 | 11篇 |
一般理论 | 1篇 |
预防医学 | 82篇 |
眼科学 | 44篇 |
药学 | 311篇 |
中国医学 | 4篇 |
肿瘤学 | 392篇 |
出版年
2023年 | 43篇 |
2022年 | 85篇 |
2021年 | 125篇 |
2020年 | 56篇 |
2019年 | 67篇 |
2018年 | 79篇 |
2017年 | 58篇 |
2016年 | 83篇 |
2015年 | 73篇 |
2014年 | 99篇 |
2013年 | 153篇 |
2012年 | 205篇 |
2011年 | 196篇 |
2010年 | 108篇 |
2009年 | 95篇 |
2008年 | 136篇 |
2007年 | 163篇 |
2006年 | 178篇 |
2005年 | 156篇 |
2004年 | 110篇 |
2003年 | 127篇 |
2002年 | 135篇 |
2001年 | 64篇 |
2000年 | 62篇 |
1999年 | 52篇 |
1998年 | 25篇 |
1997年 | 31篇 |
1996年 | 27篇 |
1995年 | 15篇 |
1994年 | 9篇 |
1993年 | 16篇 |
1992年 | 79篇 |
1991年 | 58篇 |
1990年 | 62篇 |
1989年 | 35篇 |
1988年 | 40篇 |
1987年 | 27篇 |
1986年 | 32篇 |
1985年 | 32篇 |
1984年 | 24篇 |
1983年 | 28篇 |
1979年 | 9篇 |
1977年 | 5篇 |
1975年 | 7篇 |
1973年 | 10篇 |
1972年 | 8篇 |
1971年 | 3篇 |
1970年 | 3篇 |
1968年 | 4篇 |
1966年 | 3篇 |
排序方式: 共有3323条查询结果,搜索用时 15 毫秒
61.
M Nishimura Y Kumamoto T Hirose M Koroku M Hojo S Sakai T Tsukamoto K Deguchi 《Kansenshōgaku zasshi. The Journal of the Japanese Association for Infectious Diseases》1992,66(6):743-753
Epidemiological and bacteriological studies on Neisseria gonorrhoeae isolated in Sapporo, Japan, in 1980 and 1991 performed and the following results were obtained. 1. The range of age in the patients infected with Neisseria gonorrhoeae tended to be younger than those in the whole country. 2. Male patients in the early 20s or younger with gonococcal urethritis were often infected by bon-professional females but those in their late 20s or older were often infected from professional females, for example prostitutes and hostesses. 3. The rate of professional females who were positive to gonococci reached 17.4% and young females in their teens with cervicitis had the highest morbidity rate of gonococci than those in the older females. 4. The latent period in gonococcal infections tended to become longer gradually. 5. The isolation rate of penicillinase producing Neisseria gonorrhoeae (PPNG) showed a peak of 23.9% (61/255) in 1985, but gradually declined thereafter and it was 3.7% (1/27) in 1991. 6. An investigation on auxotype showed a decline of proto and Pro-strains and an increase of AHU-strains in non-PPNG. And most of the PPNG belonged to proto or Pro-strains. 7. With the relationship between auxotype and sensitivity to AMPC, AHU-strains were more sensitive than proto or Pro-strains. 相似文献
62.
Deguchi H Fernandez JA Hackeng TM Banka CL Griffin JH 《Proceedings of the National Academy of Sciences of the United States of America》2000,97(4):1743-1748
Anticardiolipin (anti-CL) antibodies, diagnostic for antiphospholipid antibody syndrome, are associated with increased risks of venous and arterial thrombosis. Because CL selectively enhances activated protein C/protein S-dependent anticoagulant activities in purified systems and because CL is not known to be a normal plasma component, we searched for CL in plasma. Plasma lipid extracts [chloroform/methanol (2:1, vol/vol)] were subjected to analyses by using TLC, analytical HPLC, and MS. A plasma lipid component was purified that was indistinguishable from reference CL (M:1448). When CL in 40 fasting plasma lipid extracts (20 males, 20 females) was quantitated by using HPLC, CL (mean +/- SD) was 14.9 +/- 3.7 microgram/ml (range 9.1 to 24.2) and CL was not correlated with phosphatidylserine (3.8 +/- 1.7 microgram/ml), phosphatidylethanolamine (64 +/- 20 microgram/ml), or choline-containing phospholipid (1,580 +/- 280 microgram/ml). Based on studies of fasting blood donors, CL (>/=94%) was recovered in very low density, low density, and high density lipoproteins (11 +/- 5.3%, 67 +/- 11.0%, and 17 +/- 10%, respectively), showing that the majority of plasma CL (67%) is in low density lipoprotein. Analysis of relative phospholipid contents of lipoproteins indicated that high density lipoprotein is selectively enriched in CL and phosphatidylethanolamine. These results shows that CL is a normal plasma component and suggest that the epitopes of antiphospholipid antibodies could include CL or oxidized CL in lipoproteins or in complexes with plasma proteins (e. g., beta(2)-glycoprotein I, prothrombin, protein C, or protein S) or with platelet or endothelial surface proteins. 相似文献
63.
Hirota Tomoya McElroy Eoin So Ryuhei 《Journal of autism and developmental disorders》2021,51(8):2764-2772
Journal of Autism and Developmental Disorders - In the present study, we employed network analysis that conceptualizes internet addiction (IA) as a complex network of mutually influencing symptoms... 相似文献
64.
65.
Huan Li Yanan Wang Yutaro Aoki Saki Nishiyama Xiaofan Yang Tomoya Taguchi Akari Miura Ai Suzuki Lei Zhi Hidenori Goto Ritsuko Eguchi Takashi Kambe Yen-Fa Liao Hirofumi Ishii Yoshihiro Kubozono 《RSC advances》2020,10(45):26686
A superconducting KBi2 sample was successfully prepared using a liquid ammonia (NH3) technique. The temperature dependence of the magnetic susceptibility (M/H) showed a superconducting transition temperature (Tc) as high as 3.6 K. In addition, the shielding fraction at 2.0 K was evaluated to be 87%, i.e., a bulk superconductor was realized using the above method. The Tc value was the same as that reported for the KBi2 sample prepared using a high-temperature annealing method. An X-ray diffraction pattern measured based on the synchrotron X-ray radiation was analyzed using the Rietveld method, with a lattice constant, a, of 9.5010(1) Å under the space group of Fdm (face-centered cubic, no. 227). The lattice constant and space group found for the KBi2 sample using a liquid NH3 technique were the same as those reported for KBi2 through a high-temperature annealing method. Thus, the superconducting behavior and crystal structure of the KBi2 sample obtained in this study are almost the same as those for the KBi2 sample reported previously. Strictly speaking, the magnetic behavior of the superconductivity was different from that of a KBi2 sample reported previously, i.e., the KBi2 sample prepared using a liquid NH3 technique was a type-II like superconductor, contrary to that prepared using a high-temperature annealing method, the reason for which is fully discussed. These results indicate that the liquid NH3 technique is effective and simple for the preparation of a superconducting KBi2. In addition, the topological nature of the superconductivity for KBi2 was not confirmed.A superconducting KBi2 sample was successfully prepared using a liquid ammonia (NH3) technique. 相似文献
66.
Masahiro Seiryu Hiroto Ida Atsushi Mayama Satoshi Sasaki Shutaro Sasaki Toru Deguchi Teruko Takano-Yamamoto 《The Angle orthodontist》2020,90(1):3
ObjectivesTo investigate the hypothesis that there is difference in the treatment outcomes of milder skeletal Class III malocclusion between facemask and facemask in combination with a miniscrew in growing patients.Materials and MethodsPatients were randomly divided into two groups. In one group, the patients were treated with facemask therapy (FM group: 12 males, eight females, average age: 10 years, 5 months ± 1 year, 8 months). In the other group, patients were treated with facemask therapy along with a miniscrew (FM+MS group: 12 males, seven females, average age: 11 years, 1 month ± 1 year, 3 months). A lingual arch with hooks was fixed to the maxillary arch in both groups and a protractive force of 500 g was applied from the facemask to the hooks. The patients were instructed to use the facemask for 12 hours per day. In the FM+MS group, a miniscrew was inserted into the palate and fixed to the lingual arch.ResultsMobility and loosening of the miniscrew were not observed during treatment. Lateral cephalometric analysis showed that SNA, SN-ANS, and ANB values were significantly increased in the FM+MS group compared with those for the FM group (SNA, 1.1° SN-ANS, 1.3° ANB, 0.8°). Increase in proclination of maxillary incisors was significantly greater in the FM group than in the FM+MS group (U1-SN, 5.0°).ConclusionsDuring treatment of milder skeletal Class III malocclusion, facemask therapy along with a miniscrew exhibits fewer negative side effects and delivers orthopedic forces more efficiently to the maxillary complex than facemask therapy alone. 相似文献
67.
Eisuke Suganuma Hideaki Sakata Nodoka Adachi Satoshi Asanuma Mihoko Furuichi Yoji Uejima Satoshi Sato Tomoya Abe Daigo Matsumoto Ryohei Takahashi Sachi Yamamoto Yutaka Kawano Takashi Arai Tsutomu Oh-ishi 《Journal of infection and chemotherapy》2021,27(2):185-191
ObjectivesValganciclovir (VGCV) has been shown to improve sensorineural hearing loss (SNHL) and neurological outcomes in patients with neonatal symptomatic congenital cytomegalovirus (cCMV) infection. However, reports on the pharmacokinetics, efficacy and safety of oral VGCV are limited. The aim of this study is to evaluate the pharmacokinetics of VGCV for use in the treatment of cCMV.MethodsThis was a single-center, retrospective observational study conducted at Saitama Children's Medical Center in Japan between 2012 and 2017. CMV DNA copy number, maximum plasma VGCV concentration (Cmax), and adverse events (ADEs) during treatment were evaluated.ResultsA total of 26 patients with cCMV who received VGCV were included in this study. The median age at VGCV initiation was 9.5 months (range 0–46). Twenty-one patients (81%) had SNHL at baseline. Of these, five patients (19%) presented with improved SNHL, and none experienced worsened SNHL during treatment. The mean VGCV Cmax was 3.5 μg/mL (range 2–5.3), with no significant variation among individual values, and the values were maintained during treatment. Furthermore, there were no correlations between the Cmax values and age, sex, SNHL improvement or ADEs. Neutropenia (<1000/mm3) was observed in six patients (23%); however, no serious ADEs occurred.ConclusionsVGCV prevented the progression of SNHL without serious ADEs due to its stable pharmacokinetics. This study provides safety and tolerability of VGCV for the treatment of cCMV patients. 相似文献
68.
69.
Igarashi Y Mita T Mizuno R Watada H Tanaka Y Kawamori R Hirose T 《Endocrine journal》2005,52(6):683-689
In this retrospective longitudinal study, we focused on the clinical characteristics of Japanese individuals with recent onset impaired glucose tolerance (IGT) who have been followed up for insulin secretory function and 75-gram oral glucose tolerance test (OGTT) for more than 3 years annually before they progressed from normal glucose tolerance (NGT) to IGT. Subjects whose body weight did not show significant change for the period were selected and labeled as either NGT (no change in OGTT over 3 years) or IGT (progressors from NGT to IGT) groups (n = 24, each). We compared the basal biochemical data and response of plasma glucose and serum insulin after OGTT of the two groups. In the IGT progressors, significant increase of plasma glucose at 30 to 120 minutes during OGTT and significant decrease of HDL-cholesterol were observed since 3 years before onset of IGT. In addition to increase of serum glucose and decrease of HDL-cholesterol, serum insulin at 120 minutes during OGTT were significantly and remarkably high at onset and 3 years before onset of IGT. Plasma glucose at 30-120 minutes and serum insulin level at 120 minutes after glucose load are potentially significant predictors of progression from NGT to IGT even in subjects who do not show increase of body weight. 相似文献
70.