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Influence of Vertical Soft Tissue Thickness on Crestal Bone Changes Around Implants with Platform Switching: A Comparative Clinical Study 下载免费PDF全文
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Fausto Biancari Tomas Gudbjartsson Jouni Heikkinen Vesa Anttila Timo Mäkikallio Anders Jeppsson Linda Thimour-Bergström Carmelo Mignosa Antonino S. Rubino Kari Kuttila Jarmo Gunn Jan-Ola Wistbacka Kari Teittinen Kari Korpilahti Francesco Onorati Giuseppe Faggian Giulia Vinco Corrado Vassanelli Flavio Ribichini Tatu Juvonen Tomas A. Axelsson Axel F. Sigurdsson Pasi P. Karjalainen Ari Mennander Olli Kajander Markku Eskola Erkki Ilveskoski Veronica D'Oria Marisa De Feo Tuomas Kiviniemi K.E. Juhani Airaksinen 《The American journal of cardiology》2014
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We hypothesized that decreasing elevated night‐time heart rate (HR) in hypertension by administering a bradycardic agent (ivabradine) at bedtime could bring cardiovascular benefit. Since rats are nocturnal animals, they exhibit circadian rhythms phase‐shifted relative to humans. Sixty‐six Wistar rats were divided into non‐diseased controls and rats with l ‐NAME‐induced hypertension to compare the haemodynamic effects of daytime‐dosed and night‐time‐dosed ivabradine. l ‐NAME‐induced hypertension inverted the physiological 5.6% night‐to‐day HR dip to an undesirable HR rise by 11.1%. Ivabradine dosed at daytime (the rat's resting phase) reverted a night‐to‐day HR rise to HR dip by 14.2%. These results suggest a cardiovascular benefit of ivabradine dosed at the human's resting phase (night‐time) for hypertensive patients with nondipping HR. 相似文献
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Podhorec P Socha M Sokolowska-Mikolajczyk M Policar T Svinger VW Drozd B Kouril J 《General and comparative endocrinology》2012,175(1):34-38
Tench (Tinca tinca) is apparently the only known member of the Cyprinidae in which ovulation is stimulated following administration of a low dose of GnRH analogue (GnRHa) without a dopamine inhibitor. This study evaluated LH release effectiveness of the most commonly used GnRHa and clarified whether LH secretion followed by ovulation is subject to inhibitory dopaminergic control in tench. Fish were intraperitoneally injected with three types of GnRHa, GnRHa with dopamine inhibitor metoclopramide (combined treatment), or the dopamine inhibitor metoclopramide alone. LH concentrations at five sampling times (0, 6, 12, 24, and 33 h) together with ovulation success and fecundity index were recorded. The combined treatment triggered an almost immediate LH release peak with a gradual decline, and resulted in a high ovulation rate. In contrast to the combined treatment, an application of GnRHa alone at 10 μg kg(-1) induced gradual increase of LH concentrations with peaks close to ovulation time, and with high ovulation success. Significant differences in LH concentrations at 6 and 12h and no differences in ovulation success were found between the combined and the GnRHa alone treatments. Metoclopramide alone induced a small increase in LH with no ovulation. The study presents clear evidence of dopaminergic control of LH release in tench, with a high ovulation rate obtained after application of GnRHa alone or in combination with dopamine inhibitor. 相似文献
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