全文获取类型
收费全文 | 15887篇 |
免费 | 993篇 |
国内免费 | 190篇 |
专业分类
耳鼻咽喉 | 382篇 |
儿科学 | 202篇 |
妇产科学 | 291篇 |
基础医学 | 2761篇 |
口腔科学 | 295篇 |
临床医学 | 1218篇 |
内科学 | 3112篇 |
皮肤病学 | 456篇 |
神经病学 | 1245篇 |
特种医学 | 1046篇 |
外科学 | 2108篇 |
综合类 | 72篇 |
现状与发展 | 3篇 |
一般理论 | 10篇 |
预防医学 | 625篇 |
眼科学 | 431篇 |
药学 | 1324篇 |
中国医学 | 154篇 |
肿瘤学 | 1335篇 |
出版年
2024年 | 12篇 |
2023年 | 135篇 |
2022年 | 376篇 |
2021年 | 671篇 |
2020年 | 274篇 |
2019年 | 449篇 |
2018年 | 532篇 |
2017年 | 425篇 |
2016年 | 618篇 |
2015年 | 880篇 |
2014年 | 965篇 |
2013年 | 1057篇 |
2012年 | 1595篇 |
2011年 | 1465篇 |
2010年 | 852篇 |
2009年 | 720篇 |
2008年 | 909篇 |
2007年 | 923篇 |
2006年 | 793篇 |
2005年 | 637篇 |
2004年 | 531篇 |
2003年 | 477篇 |
2002年 | 390篇 |
2001年 | 303篇 |
2000年 | 243篇 |
1999年 | 187篇 |
1998年 | 73篇 |
1997年 | 58篇 |
1996年 | 34篇 |
1995年 | 37篇 |
1994年 | 24篇 |
1993年 | 30篇 |
1992年 | 42篇 |
1991年 | 43篇 |
1990年 | 36篇 |
1989年 | 38篇 |
1988年 | 31篇 |
1987年 | 33篇 |
1986年 | 20篇 |
1985年 | 16篇 |
1984年 | 10篇 |
1983年 | 11篇 |
1981年 | 14篇 |
1980年 | 9篇 |
1979年 | 15篇 |
1978年 | 10篇 |
1977年 | 10篇 |
1976年 | 10篇 |
1975年 | 9篇 |
1973年 | 6篇 |
排序方式: 共有10000条查询结果,搜索用时 9 毫秒
11.
目的评估十二指肠-空肠导管(Endoluminal Duodeno-Jejunal Tube,EDJT)在活体猪实验动物模型中减缓体重增加的可行性,及其在中短期生存中的安全性。方法本项研究共用8只45kg重的Yorkshire猪,其中3只置入180emEDJT,1只置入360cm EDJT,另4只猪作为对照组。切开十二指肠,将EDJT导管缝合固定在十二指肠近Vater壶腹起始处。结果评估全部猪的不适反应和体重,每日一次,共7周,未发现严重并发症发生。术后7周3组动物的平均体重变化百分率:对照组、180cm组和360cm组分别是22.5%,6%和-2.8%。EDJT组(180cm组、360cm组)体重增加明显减慢,与对照组相比,有统计学意义(P=0.05)。结论EDJT可以安全使用,无肠梗阻、肠套叠或胰腺炎等并发症发生。EDJT可明显减缓体重增加。 相似文献
12.
Epidemiologic studies have demonstrated that trans fat intake increases the risk of some chronic diseases. We hypothesize that trans fat intake would increase the risk of cardiovascular disease and type 2 diabetes mellitus by changing the lipid profile in plasma, the secretion of adipokines in adipose tissue, and the insulin sensitivity. Accordingly, the major objective of present study was to investigate the effect of dietary intake of trans fat on lipid profile, insulin sensitivity, and adipokine levels in plasma. Two groups of Wistar rats were fed a diet containing 4.5% trans fat or a control diet containing no trans fat for 16 weeks. Fasting glucose level was monitored every 2 weeks. At the end of feeding experiment, blood, heart, kidney, liver, omental adipose tissue, and semitendinosus muscle were collected. The trans fat content in organs, lipid profile, adipokine, insulin, and glucose levels in plasma were analyzed. The trans fat content in adipose tissue, heart, kidney, liver, and muscle of rats fed trans fat were 169.9, 0.6, 1.2, 1.7, and 2.5 mg/g samples, respectively. The trans fat content in these organs contributed to 15.9%, 1.2%, 2.3%, 4.3%, and 6.1% of the total fat, respectively. The plasma glucose level, insulin level, and insulin sensitivity index were not significantly different between the trans fat and control groups. The results indicated that trans fat intake might not be related to insulin resistance. However, lipid profile and plasma adipokine levels were significantly changed after trans fat feeding. The trans fat fed group showed significantly lower total cholesterol and high-density lipoprotein cholesterol levels than the control group. The decreased high-density lipoprotein cholesterol level may indicate the detrimental effect of trans fat intake on lipid profile. Adiponectin and resistin levels were significantly higher in the trans fat group than the control group. Leptin levels were significantly lower in the trans fat group than the control group. The results indicated that dietary intake of trans fat can significantly change the adipokine levels, but the possible links between adipokine level change caused by trans fat intake and metabolic effects of this change need further investigations. 相似文献
13.
The coexistence of otosclerosis and endolymphatic hydrops in the temporal bone have been described; however, the mechanism for the development of endolymphatic hydrops in otosclerosis remains unknown. Among 128 temporal bones with otosclerosis, involvement of the vestibular aqueduct by otosclerosis was observed in four temporal bones from two patients. In all four, the vestibular aqueduct was filled with active otosclerotic foci; the lumen of the endolymphatic duct and sac was narrowed as a result of fibrosis, and endolymphatic hydrops, more severe in the pars inferior than the pars superior, was observed. Collapse of the ductus reuniens and dilated saccule was seen in three temporal bones. Our study indicates that otosclerotic obstruction of the vestibular aqueduct may create a disturbance of the outflow and/or absorption of endolymph, leading to the development of endolymphatic hydrops and Meniere's disease, thus supporting the theory of longitudinal flow of endolymph. 相似文献
14.
Hea-Young P. Choo Hea-Ran Yoon Hwha-Soon Park Dong-Hyun Kim Jongsei Park Dong H. Kim 《Archives of pharmacal research》1998,21(2):168-173
The epoxyalkanoyl derivatives were designed and synthesized as ACE inhibitors. Coupling of unsaturated carboxylic acids with amino acids and following epoxidation with dimethyldioxirane gave the epoxyalkanoyls with high yield. The inhibitory activity of synthesized compounds on angiotensin converting enzyme was IC50 values of 0.06≈5.5 μM. 相似文献
15.
Dong Hwee Kim Yoon Kyoo Kang Miriam Hwang Ho Sung Jo Ki Hoon Kim 《Clinical neurophysiology》2004,115(5):1021-1026
OBJECTIVE: To evaluate the usefulness of the TenElectrodes, a new stimulator for inching test, in the diagnosis and localization of ulnar neuropathy at the elbow (UNE). METHODS: Sixty-two ulnar nerves in 40 control subjects and 24 ulnar nerves in 23 patients with typical symptoms and signs of UNE were studied. The inching test of ulnar motor nerve using TenElectrodes was done along 8 cm across the elbow in the extended position. RESULTS: In the inching test of the control group, the mean segmental latency difference was 0.19+/-0.08 ms. Maximal latency difference over a 1 cm segment did not exceed 0.40 ms in any of the controls but exceeded 0.5 ms or more in all clinical UNE patients. In all UNE patients, the lesion sites were identified by the inching test using TenElectrodes: the retroepicondylar groove (54.2%), the humeroulnar arcade (29.2%), and dual compression (16.6%). CONCLUSIONS: TenElectrodes is a useful stimulator for the inching test in the diagnosis of UNE. The precise localization of compression was possible in all patients with UNE and the most common site was the retroepicondylar groove. 相似文献
16.
Hyun Jik Kim Jinna Kim Joo-Heon Yoon 《European archives of oto-rhino-laryngology》2006,263(8):778-782
Olfactory neuroblastoma is a rare, malignant neoplasm arising from the olfactory epithelium. It has an aggressive biological behavior that is characterized by local recurrence, atypical distant metastasis, and poor long-term prognosis. The incidence of cervical lymph node metastasis in olfactory neuroblastoma is variable, and treatment modalities are controversial. Moreover, few reports have been published concerning retropharyngeal lymph node metastasis from olfactory neuroblastoma. We present two cases of olfactory neuroblastoma with retropharyngeal lymph node metastasis. In addition, we provided a review of the current literature regarding olfactory neuroblastoma and retropharyngeal lymph node metastasis from olfactory neuroblastoma. 相似文献
17.
A case of recurrent gastric cancer successfully treated with a combination of cisplatin and carmofur
R Kuwatsuru S Akazawa S Yoon K Yamamoto K Yoshida K Saifuku S Abe T Fujiki Y Kanda K Futatsuki 《Gan to kagaku ryoho. Cancer & chemotherapy》1987,14(11):3143-3147
A 51-year-old man with recurrent gastric cancer was treated by combined administration of Cisplatin and Carmofur. The target sites were the abdominal lymph nodes and the area of invasion to the stomach. Cisplatin (50 mg/body/day) was given for 3 days, while Carmofur (400-800 mg/body/day) was administered daily in 1 course. After 1 course of administration, the target tumor was reduced in size and the therapy was continued. A complete response was confirmed by upper gastrointestinal roentgenography, endoscopy and echography after 8 courses of Cisplatin administration. The patient has survived for 2 years 6 months in a state of CR. This case suggests that a combination therapy of Cisplatin and Fluoropyrimidine derivatives might be effective for gastric cancer. 相似文献
18.
19.
Fontan conversion with arrhythmia surgery. 总被引:2,自引:0,他引:2
Woong-Han Kim Hong Gook Lim Jeong Ryul Lee Joon Ryang Rho Eun Jung Bae Chung Il Noh Yong Soo Yoon Yong Jin Kim 《European journal of cardio-thoracic surgery》2005,27(2):250-257
OBJECTIVE: Hemodynamic abnormalities and refractory atrial arrhythmias in patients late after the Fontan operation result in significant morbidity and mortality. We reviewed our experience with Fontan conversion and concomitant arrhythmia surgery. METHODS: Between January 1996 and February 2004, 16 patients underwent Fontan conversion and arrhythmia surgery. Mean age at the initial Fontan operation was 5.1+/-3.5 (range: 2-15) years and mean age at Fontan conversion was 17.0+/-5.8 (range: 6-30). The initial Fontan operations were atriopulmonary connections in 14 patients, extracardiac lateral tunnel in 1, and intracardiac lateral tunnel in 1. The types of arrhythmia included atrial flutter in 10 patients and atrial fibrillation in 3. Fontan conversion operation was performed with intracardiac lateral tunnel in 5 patients and extracardiac conduit in 11. Arrhythmia surgery included isthmus cryoablation in 10 patients and right-sided maze in 3. RESULTS: There has been no mortality. At Fontan conversion operation, 7 patients required permanent pacemaker. All patients have improved to New York Heart Association class I or II. With a mean follow-up of 26.9+/-30.6 (range:1-87) months, 16 patients had sinus rhythm, 2 patients had transient atrial flutter which was well controlled, and 2 patients required permanent pacemaker during follow-up. CONCLUSIONS: Fontan conversion with concomitant arrhythmia surgery and permanent pacemaker placement is safe, improves New York Heart Association functional class, and has a low incidence of recurrent arrhythmias. In most patients, concomitant permanent pacemakers are needed. 相似文献
20.