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991.
DONALD L. BUTLER MB. BS MERLE de SILVA DMRD RCP & S MRACR 《Journal of paediatrics and child health》1980,16(4):279-283
Intracranial haemorrhage was found in 22 infants with the aid of computerised tomography (CT). Six (27%) of these infants were full-term. Seven infants died (32%). Most infants displayed clinical features normally associated with intracranial haemorrhage (ICH), but In two Infants fever was the most striking presenting sign of the haemorrhage. Lumbar puncture was only helpful in diagnosing intraventricular haemorrhage.
Three types of haemorrhages were seen on the scans: intracerebral, subdivided Into subependymal, intracerebral and cortical; intraventricular; and midline interhemispheric. The latter haemorrhage was shown at autopsy to be located within the falx. This type of haemorrhage was seen in 19 of the 22 cases, both as an isolated haemorrhage and more usually, in combination with the other types. 相似文献
Three types of haemorrhages were seen on the scans: intracerebral, subdivided Into subependymal, intracerebral and cortical; intraventricular; and midline interhemispheric. The latter haemorrhage was shown at autopsy to be located within the falx. This type of haemorrhage was seen in 19 of the 22 cases, both as an isolated haemorrhage and more usually, in combination with the other types. 相似文献
992.
K. H. SIT MB BS PhD H. B. WONG MB BS FRCP FRCP FRACP DCH 《Journal of paediatrics and child health》1980,16(3):201-204
Second trimester abortuses induced by prostaglandin E2 were karyotyped. Twenty (11.9%) had chromosomal aberrations. These were diploid aberrations except for one case of double Y male. Twelve, however, were genetically balanced chromosomal rearrangements, and two had deletions of acrocentric G group chromosome short arms which should have no phenotypic effects. Only 5 cases out of 20 or 2.98% of 168 karyotyped could be classified as having serious chromosomal defects. These were all structural lesions, suggesting a shift from aneuploidy in first trimester abortuses to diploidy in second trimester induced abortuses. The decline In fetal deaths In the second trimester of pregnancy might therefore be associated not so much with a decline in the frequency of chromosomal aberrations but apparently with a limitation of the more extreme variations through selection and greater maturity. 相似文献
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Nancy Habib BS Cristina Salaro MD Khalid Al‐Ghaithi MD Robert G. Phelps MD Sarika Saggar MD Steven R. Cohen MD MPH 《International journal of dermatology》2010,49(1):91-94
Background Aphthous stomatitis, a common mucocutaneous disorder, is a well accepted complication of sirolimus therapy. This association has been reported less frequently with tacrolimus. Case We present an 11‐year old male with Budd‐Chiari syndrome who experienced profound worsening of chronic aphthous ulcers after immunosuppressive therapy was changed from tacrolimus to sirolimus. Conclusion Since these drugs are used widely in the pediatric transplantation population, this report serves to heighten awareness of this debilitating phenomenon, and to stress the importance of exercising caution when sirolimus and tacrolimus are administered in combination to pediatric patients. 相似文献
995.
R. Michael Koch MD ; Nanette S. Roche BS ; W. Tony Parks MD ; Gillian S. Ashcroft MD PhD ; John J. Letterio MD ; Anita B. Roberts PhD 《Wound repair and regeneration》2000,8(3):179-191
Expression of endogenous transforming growth factor-beta1 is reduced in many animal models of impaired wound healing, and addition of exogenous transforming growth factor-beta has been shown to improve healing. To test the hypothesis that endogenous transforming growth factor-beta1 is essential for normal wound repair, we have studied wound healing in mice in which the transforming growth factor-beta1 gene has been deleted by homologous recombination. No perceptible differences were observed in wounds made in 3-10-day-old neonatal transforming growth factor-beta1 null mice compared to wild-type littermates. To preclude interference from maternally transferred transforming growth factor-beta1, cutaneous wounds were also made on the backs of 30-day-old transforming growth factor-beta1 null and littermate control mice treated with rapamycin, which extends their lifetime and suppresses the inflammatory response characteristic of the transforming growth factor-beta1 null mice. Again, no impairment in healing was seen in transforming growth factor-beta1 null mice. Instead these wounds showed an overall reduction in the amount of granulation tissue and an increased rate of epithelialization compared to littermate controls. Our data suggest that release of transforming growth factor-beta1 from degranulating platelets or secretion by infiltrating macrophages and fibroblasts is not critical to initiation or progression of tissue repair and that endogenous transforming growth factor-beta1 may actually function to increase inflammation and retard wound closure. 相似文献
996.
Stamatia Destounis MD Andrea Arieno BS Patricia A. Somerville MD Posy J. Seifert DO Philip Murphy MD Renee Morgan RT Melissa Skolny BA Sarah Hanson BA Wende Young MD 《Journal of ultrasound in medicine》2009,28(10):1337-1346
Objective. The purpose of this study was to assess the utility and efficacy of second‐look breast sonography in the evaluation of abnormalities identified on presurgical breast magnetic resonance imaging (MRI) examinations. Methods. A retrospective review was performed of 152 presurgical breast MRI examinations having 196 unsuspected abnormalities to identify findings that underwent subsequent breast sonography. Eligible examinations had a suspicious abnormality identified on presurgical MRI and documentation of the location and size of the finding on MRI and subsequent second‐look sonography. Fourteen examinations not meeting the criteria were excluded, with 182 abnormalities remaining. Patient medical records were reviewed. Results. Seventy percent (128 of 182) of breast MRI lesions were visible at second‐look sonography; 30% (54 of 182) were sonographically occult. Ninety‐five percent (121 of 128) of sonographically visible abnormalities underwent breast biopsy. Pathologic examinations of sampled sonographically visible lesions revealed 39 cancers, 9 high‐risk lesions, 72 benign lesions, and 1 lesion not specified at surgery; 23% (9 of 128) of cancers were in the contralateral breast. Fifty‐four lesions were sonographically occult. Needle biopsy was performed for 93% (50 of 54) of occult lesions, revealing 8 cancers, 1 high‐risk lesion, and 41 benign lesions; 3 of the benign lesions did not have sufficient pathologic specimens but were benign at follow‐up. Magnetic resonance imaging guidance was used in 86% (43 of 50) of these biopsies. One contralateral cancer was identified in the sonographically occult subset. Of the 182 lesions that underwent second‐look sonography, 20% (36 of 182) had a change in management. Conclusions. Second‐look sonography has value in the evaluation of abnormalities found on breast MRI. We found enhancements in 70% (128 of 182), yielding 39 cancers. 相似文献
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