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31.
Yoshio Mii Yoshizumi Miyauchi Kanya Hohnoki Hiroshi Maruyama Masahiro Tsutsumi Kayoko Dohmae Susumu Tamai Yoichi Konishi Takahisa Yamanouchi 《Virchows Archiv : an international journal of pathology》1989,415(1):51-60
Summary In order to clarify the histogenesis of clear cell sarcoma of tendons and aponeuroses (CCS), two cases of human and one nude mouse-transplanted CCS line were studied using an ultrastructural and enzyme cytochemical approach. Most of the tumour cells obtained from the primary and transplanted CCS demonstrated melanosomes in various stages of development within the cytoplasm, whereas no melanosomes could be identified in the metastatic CCS. However, cholinesterase and tyrosinase activities could be demonstrated not only in the melanotic primary and transplanted CCS but also in the amelanotic metastatic CCS. The results therefore support the hypothesis that CCS is a soft tissue tumour derived from the neural crest. 相似文献
32.
Geographic or ethnic differences in the incidence of thyroid carcinoma, as well as in the histologic distribution of thyroid
carcinoma between Japan and Western countries, have been described but are still unclear. The recent establishment of histologic
criteria for the diagnosis of thyroid carcinoma by the WHO committee has facilitated the comparison of clinicopathological
data of patients with thyroid carcinoma all over the world. The aim of the present review article is to clarify the epidemiological
and clinicopathological differences of thyroid carcinoma between Japan and Western countries. We found recently no significant
differences in the incidence, mortality, and histologic distribution of thyroid carcinoma between Japan and Western countries;
this was contrary to our expectation. This is likely attributable to westernization of the Japanese diet, standardized medical
levels, and international standardization of histologic criteria of thyroid carcinoma. 相似文献
33.
Kennichi Kakudo Akira Miyauchi Shin-ichiro Takai Shoichi Katayama Kanji Kuma Hajime Kitamura 《Pathology international》1979,29(4):653-659
Two cases of papillary type of C cell carcinoma of the thyroid were reported. They showed papillary arrangement with Abrovascular stalk in properly Axed tissues. Histochemically argyrophil reaction was positive in the cytoplasm and amyloid deposited in the stroma. Ultrastructurally secretory granules were found in their cytoplasm. The papillary type is not an artifact but one of the histologic variations of this carcinoma. ACTA PATH. SAP. 29: 653–659, 1979. 相似文献
34.
Electron microscopic evidence of a viral nature for osteoclast inclusions in Paget's disease of bone
Y. Mii Y. Miyauchi K. Honoki T. Morishita S. Miura M. Aoki S. Tamai S. Tsunoda M. Nishitani T. Sakaki 《Virchows Archiv : an international journal of pathology》1994,424(1):99-104
Circumstantial evidence from electron microscopic and immunological studies support the view that Paget's disease of bone represents a slow virus infection. However, there is only limited information available regarding its electron microscopic, enzyme and immunocytochemical characteristics. Two cases were studied using electron microscopy with particular emphasis on the inclusions in osteoclasts. Detailed ultrastructural and cytochemical studies including immuno-electron microscopy were performed. Some osteoclasts demonstrated specific virus-like structures composed of aggregations of microtubules in the nucleus and cytoplasm. The structures were easily digested by trypsin or protease, and were sensitive to RNase, which provided substantial evidence of a proteinaceous nature and inclusion of ribonucleic acid. Immunocytochemical examination identified binding of anti-respiratory syncytial virus and anti-measles virus antibodies in the tissue obtained from one of the two cases examined. The presence of viral antigens in structures in the cytoplasm of Pagetic osteoclasts supports the theory of paramyxovirus involvement in this disease. 相似文献
35.
N Yamamoto M Watanabe F Matsuzuka A Miyauchi Y Iwatani 《Clinical and experimental immunology》2004,138(3):555-559
To investigate the roles of soluble CD4 (sCD4) and CD8 (sCD8) in the severity of autoimmune thyroid diseases, we examined serum concentrations of sCD4 and sCD8 in various degrees of severity of Hashimoto's disease (HD) and Graves' disease (GD) by enzyme immunoassay. The serum concentration of sCD8 was lower in euthyroid patients with HD undergoing treatment for hypothyroidism (severe HD) than in untreated, euthyroid patients with HD (mild HD), but the sCD4 concentration did not differ between patients with severe and mild HD. The serum sCD8 concentration was negatively correlated with the proportion of CD25(+) cells in CD8(+) cells in patients with severe HD. Serum sCD4 and sCD8 concentrations did not differ between euthyroid patients with GD in remission and those with intractable GD. These results indicate that serum sCD8 is involved in the severity of HD, possibly by down-regulating the function of cytotoxic T cells. 相似文献
36.
T. Wieloch Y. Miyauchi O. Lindvall 《Experimental brain research. Experimentelle Hirnforschung. Expérimentation cérébrale》1990,83(1):159-163
Summary Transient periods of global cerebral ischemia lead to selective neuronal damage in the striatum. We investigated the effects of unilateral 6-hydroxydopamine lesions of the mesostriatal dopamine (DA) system on the density and distribution of neuronal necrosis in the rat striatum following ischemia induced by bilateral occlusion of the common carotid arteries combined with hypotension. After both 12 and 15 min of ischemia, which caused slight and extensive striatal damage, respectively, there was no difference in the density of neuronal necrosis in the striatum between DA-lesioned and shamoperated animals. We conclude that the DA system alone does not modulate injury following complete cerebral ischemia, but may contribute significantly to damage following conditions such as during hypoglycemia and incomplete cerebral ischemia. 相似文献
37.
This study deals with 11 cases of thyroid medullary carcinoma of which 7 were familial cases including 3 cases of Sipple's syndrome and 4 cases of sporadic cases. There were also 2 cases of Cushing's syndrome. In addition to the previously described English literatures about human medullary carcinoma of the thyroid, the rod-shaped body with cristae and an abundant glycogen particles in the cytoplasm, nuclear inclusion bodies of cytoplasmic invagination and microvilli at the surface membrane of gland formation were found in our cases. The mean and mode diameters of secretory granules of all familial cases with only calcitonin secretion were larger than those of the sporadic cases with ectopic AGTH and beta-MSH in addition to calcitonin secretion. Ultrastructural study on non-cancerous follicles of grossly normal thyroid of two cases of early familial medullary carcinoma disclosed apparently increased C-cells which were not intrathyroidal metastases. It is supposed that the increased C-cells in the thyroid of the familial cases are multicentric C-cell hyperplasia. ACTA PATH. JAP. 27: 605˜622, 1977. 相似文献
38.
Seiji Miyauchi Yuichi Sugiyama Yasufumi Sawada Kaname Morita Tatsuji Iga Manabu Hanano 《Journal of pharmacokinetics and pharmacodynamics》1987,15(1):25-38
Hepatic elimination of 4-methylumbelliferone (4MU), which has been used as a model compound for conjugative metabolism, was studied by means of a multiple indicator dilution (MID) method in the isolated perfused rat liver. Using this method, three intrinsic hepatic clearances, CL
int,inf
, CL
int,eff, and CL
int,seq, which represent the influx, efflux, and sequestration processes, respectively, were obtained. When the dose was increased from a low dose (50 g/rat liver) to a high dose (3000 g/rat liver), the hepatic availability of 4MU increased from 0.11 to 0.73. With increasing dose, the CL
int,eff value increased approximately two times, while the CL
int,seq value decreased to approximately one-third. The remarkable dose dependence of hepatic availability was due to nonlinearity in both CL
int,eff and CL
int,seq values. However, the CLint,inf
value was almost independent of dose. The dose-dependent change in CLint,seq
might be explained by the saturation of conjugative metabolism of 4-MU, while the increase in the CL
int,eff value with increasing dose might be partly explained by the nonlinear tissue binding of 4-MU, since the tissue unbound fraction determined by an ultrafiltration method using liver homogenate increased approximately 1.5 times at higher concentration of 4-MU compared to that at lower concentrations. In addition, based on a comparison of the individual intrinsic clearances, i.e., CL
int,inf
, CL
int,eff, and CL
int,seq, the major determining process of the apparent hepatic intrinsic clearance of 4MU is thought to be the sequestration process at the high dose. However, at the low dose, the membrane transport process (influx and efflux processes) as well as the sequestration process also determine the apparent hepatic intrinsic clearance. 相似文献
39.
H Sato Y Sugiyama S Miyauchi Y Sawada T Iga M Hanano 《Journal of pharmaceutical sciences》1986,75(1):3-8
The effect of a uniform diffusional barrier on hepatic extraction of the parent drug by evenly or unevenly distributed uni-enzyme was quantitatively determined by the present simulation study. Five models of enzymic distribution were defined with regard to the hepatic blood flow path, and the extraction ratios were calculated or simulated under the various conditions of average intrinsic clearances and diffusion clearances across hepatocytes. Differences in the extraction ratios among the five models were evaluated by the "relative extraction ratios," which are the extraction ratios in each model divided by that in the model where the enzymatic activity is evenly distributed. It was found that when a diffusion clearance was high compared to the intrinsic clearance, enzymic distribution was not an important determinant of the extent of hepatic extraction. By contrast, when a diffusional barrier across hepatocytes exists, i.e., the diffusion clearance is low or intermediate compared to the intrinsic clearance, extraction ratios differed widely among the models of enzymic distribution, especially at intermediate average intrinsic clearances. In the presence of a diffusional barrier, the more skewed the distribution of the enzymatic activity is, the lesser the amount of drug eliminated at steady state. The most efficient metabolism occurred when the enzymatic activity was evenly distributed. 相似文献