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31.
Sujino Yasumori Kuroda Kensuke Yoshitake Koichi Yagi Nobuichiro Anegawa Eiji Mochizuki Hiroki Iwasaki Keiichiro Nakajima Seiko Watanabe Takuya Yanase Masanobu Fukushima Satsuki Fujita Tomoyuki Kobayashi Junjiro Fukushima Norihide 《Journal of artificial organs》2021,24(2):265-268
Journal of Artificial Organs - Aortic insufficiency (AI) is an important adverse event in patients with continuous-flow (CF) left ventricular assist device (LVAD) support. AI is often progressive,... 相似文献
32.
Bosutinib-induced osteonecrosis of the jaw in a patient with chronic myeloid leukemia: a case report
Myoken Yoshinari Fujita Yoshinori Imanaka Ryota Toratani Shigeaki 《Oral and maxillofacial surgery》2021,25(3):421-425
Oral and Maxillofacial Surgery - Medication-related osteonecrosis of the jaw (MRONJ) is an uncommon adverse drug reaction that can be induced by certain therapeutic drugs, including antiresorptive... 相似文献
33.
Hirochika Kitagawa Ikuko Yamaoka Chihiro Akimoto Ikuko Kase Yoshihiro Mezaki Takafumi Shimizu Shigeaki Kato 《Genes to cells : devoted to molecular & cellular mechanisms》2013,18(12):1146-1146
Retraction: The above article in Genes to Cells (doi: 10.1111/j.1365‐2443.2007.01131.x ), published online on 2 November 2007 in Wiley Online Library ( http://onlinelibrary.wiley.com/ ), has been retracted by agreement between the authors, the journal Editor in Chief, Mitsuhiro Yanagida, and Wiley Publishing Asia Pty Ltd. The retraction has been agreed to due to lack of the gel images for the lanes 1, 2, 5, 6, 9 and 10 of ‘GR’ and lanes 1, 2, 9 and 10 of ‘Brg‐1’ in Figure 3(D) and the multiple usage of the gel images in Figure 3(B) and (C). 相似文献
34.
Osamu Seguchi Tomoyuki Fujita Yoshihiro Murata Masanobu Yanase Masahiro Higashi Koichi Toda Takeshi Nakatani 《Journal of artificial organs》2013,16(2):258-262
Infections associated with left ventricular assist devices (LVADs) constitute an important clinical issue because they are difficult to completely eradicate without removal of the LVAD itself and can sometimes be fatal. We encountered a case of extracorporeal LVAD-related candida infection in a patient who was successfully weaned from LVAD support. Although the patient appeared to have recovered from the infection, the patient was readmitted to our institute due to a relapse of candida infection 9 months after LVAD removal. Although the patient did not demonstrate any systemic sign of infection on admission, computed tomography images clearly showed that the residual apical cuff of the LVAD inflow cannula, which was infected with Candida albicans during the initial admission, resulted in re-infection that involved the chest wall with destruction of the adjacent rib. 相似文献
35.
36.
Tomoko Shimoike Masayoshi Goto Itsuro Nakano Takeaki Sato Yoshikatsu Migita Tetsuhide Ito Toshihiko Yanase Shu-Ichi Sezai Tsunemichi Suzuki Hajime Nawata 《Journal of gastroenterology》1997,32(6):830-835
A case of acinar-islet cell carcinoma presenting as insulinoma is reported. The patient was a 28-year-old man who presented with two convulsive episodes. Fajans' index [immunoreactive insulin (IRI; μU/ml/ glucose mg/dl)] and Turner's [IRI (μU/ml) × 100/glucose (mg/dl)—30] index were high (2.8 and 308, respectively), as were serum proinsulin levels (550pg/ml). Abdominal computed tomography and angiography revealed a highly vascular tumor in the pancreatic tail and several similar tumors in the liver. Histologic features of a biopsy specimen from a hepatic tumor were those of a malignant pancreatic endocrine tumor. Insulin secretion by the liver metastases was confirmed by venous sampling after arterial stimulation with calcium. These findings led us to diagnose malignant insulinoma with liver metastases. Serum levels of α-fetoprotein and trypsin were markedly elevated, to 2234ng/ml (normal <10) and 22000ng/ml (normal<460) respectively, and these levels continued to rise with further growth of the liver metastases. Immunohistochemically, the metastatic liver tumor specimen was positive for α-fetoprotein, α1-antichymotrypsin, chromogranin A, and neuron-specific enolase. These findings of amphicrine features in the tumor were indicative of acinar-islet cell carcinoma that produced α-fetoprotein and trypsin in addition to insulin. 相似文献
37.
Hiroko P. Indo Hsiu-Chuan Yen Ikuo Nakanishi Ken-ichiro Matsumoto Masato Tamura Yumiko Nagano Hirofumi Matsui Oleg Gusev Richard Cornette Takashi Okuda Yukiko Minamiyama Hiroshi Ichikawa Shigeaki Suenaga Misato Oki Tsuyoshi Sato Toshihiko Ozawa Daret K. St. Clair Hideyuki J. Majima 《Journal of Clinical Biochemistry and Nutrition》2015,56(1):1-7
Fridovich identified CuZnSOD in 1969 and manganese superoxide dismutase (MnSOD) in 1973, and proposed ”the Superoxide Theory,” which postulates that superoxide (O2•−) is the origin of most reactive oxygen species (ROS) and that it undergoes a chain reaction in a cell, playing a central role in the ROS producing system. Increased oxidative stress on an organism causes damage to cells, the smallest constituent unit of an organism, which can lead to the onset of a variety of chronic diseases, such as Alzheimer’s, Parkinson’s, amyotrophic lateral sclerosis and other neurological diseases caused by abnormalities in biological defenses or increased intracellular reactive oxygen levels. Oxidative stress also plays a role in aging. Antioxidant systems, including non-enzyme low-molecular-weight antioxidants (such as, vitamins A, C and E, polyphenols, glutathione, and coenzyme Q10) and antioxidant enzymes, fight against oxidants in cells. Superoxide is considered to be a major factor in oxidant toxicity, and mitochondrial MnSOD enzymes constitute an essential defense against superoxide. Mitochondria are the major source of superoxide. The reaction of superoxide generated from mitochondria with nitric oxide is faster than SOD catalyzed reaction, and produces peroxynitrite. Thus, based on research conducted after Fridovich’s seminal studies, we now propose a modified superoxide theory; i.e., superoxide is the origin of reactive oxygen and nitrogen species (RONS) and, as such, causes various redox related diseases and aging. 相似文献
38.
Nagasawa M Zhu Y Isoda T Tomizawa D Itoh S Kajiwara M Morio T Nonoyama S Shimizu N Mizutani S 《European journal of haematology》2005,74(1):54-60
CD40 ligand (CD40L) is expressed not only on activated T cells but also on activated platelets. A soluble CD40 ligand (sCD40L) is released from the activated T cells and platelets by ill-defined proteolytic process in vitro. It has been reported that sCD40L is elevated in the serum of patients with systemic lupus erythematosus, unstable angina, essential thrombocythemia, and autoimmune thrombocytopenic purupura. However, source of sCD40L in vivo remains to be elucidated. We investigated the serial sCD40L in the serum in patients undergoing allogeneic stem cell transplantation and compared with the platelets number and soluble IL2R, which is a marker of activated T cells. The value of sCD40L was well correlated with platelet number or thrombopoiesis. In cases of severe graft vs. host disease with markedly increased sIL2R, sCD40L was not increased in vivo. These results indicate that sCD40L in vivo is released mainly from the platelets or in the process of platelet production but not from the activated T cells. 相似文献
39.
40.
Shiozawa K Tanaka Y Yoshihara R Imura S Murata M Yamane T Miura Y Hashiramoto A Shiozawa S 《Modern rheumatology / the Japan Rheumatism Association》2005,15(6):405-409
Methotrexate (MTX) is the first-choice drug for rheumatoid arthritis (RA); however, the pharmacodynamics of MTX in Japanese
patients with RA treated legitimately according to the government recommended dosage, 6 mg per week, are unknown. Methotrexate
and its metabolite, 7-hydroxy MTX (7-OH MTX), were measured in sera of 16 outpatients with active RA in the first week of
MTX treatment and 4–12 weeks after the introduction at 0, 1, 2, 4, and 8 h after administration of the first and the third
2-mg capsule, followed by sampling at 48, 96, and 168 h. The mean maximal serum drug concentration (mean Cmax) of MTX attained at 1–2 h after ingestion of the first capsule was 0.215 and 0.252 μM, respectively, in the first and the
follow-up week. The mean Cmax after ingestion of the third capsule was 0.223 μM and 0.357 μM. The mean Cmax of 7-OH MTX was 0.0334 and 0.0289 μM for the first capsule, and 0.0495 and 0.0672 μM for the third capsule. The results indicate
that MTX does not accumulate or deposit in the body of Japanese patients with RA when treated with 6 mg per week, and pharmacodynamics
of MTX are comparable to those in overseas patients treated with 7.5 mg per week. 相似文献