Inverted U-Shaped Associations between Glycemic Indices and Serum Uric Acid Levels in the General Chinese Population: Findings from the China Cardiometabolic Disease and Cancer Cohort (4C) Study

Objective The relationship between serum uric acid(SUA)levels and glycemic indices,including plasma glucose(FPG),2-hour postload glucose(2 h-PG),and glycated hemoglobin(HbA1 c),remains inconclusive.We aimed to explore the associations between glycemic indices and SUA levels in the general Chinese population.Methods The current study was a cross-sectional analysis using the first follow-up survey data from The China Cardiometabolic Disease and Cancer Cohort Study.A total of 105,922 community-dwelling adults aged≥40 years underwent the oral glucose tolerance test and uric acid assessment.The nonlinear relationships between glycemic indices and SUA levels were explored using generalized additive models.Results A total of 30,941 men and 62,361 women were eligible for the current analysis.Generalized additive models verified the inverted U-shaped association between glycemic indices and SUA levels,but with different inflection points in men and women.The thresholds for FPG,2 h-PG,and HbA1 c for men and women were 6.5/8.0 mmol/L,11.0/14.0 mmol/L,and 6.1/6.5,respectively(SUA levels increased with increasing glycemic indices before the inflection points and then eventually decreased with further increases in the glycemic indices).Conclusion An inverted U-shaped association was observed between major glycemic indices and uric acid levels in both sexes,while the inflection points were reached earlier in men than in women.     

Identification of Boseongicola sediminum sp. nov., a Novel Decabromodiphenyl Ether (BDE-209)-tolerant Strain Isolated from Coastal Sediment in Xiamen,China

Polybrominated diphenyl ethers (PBDEs) are a group of aromatic organic bromine compounds, which have been used in a broad array of polymeric materials (plastics, foams, resins, and adhesives) as brominated flame retardants. They are used in commercial and household products, including textiles, electronic equipment, airplanes, and automobiles, especially in China and the USA, because they are inexpensive with excellent flame-retardant effects[1]. During the past decade, over 14,000 tonnes of PBDEs have entered the market, and have become ubiquitous environmental contaminants[2].     

纤维肌痛运动干预患者实践指南(2021年)

纤维肌痛发病率仅次于腰痛和骨关节炎,是第三常见的肌肉骨骼相关疾患.运动干预是纤维肌痛的主要治疗方法之一,患者如何更好地进行自我运动是提高纤维肌痛康复效果的关键因素.我们成立多学科专家和患者共同参与的纤维肌痛运动干预患者实践指南工作组,依据《世界卫生组织指南制订手册》原则和程序,筛选纤维肌痛患者关注的运动干预相关问题,提出纤维肌痛运动干预患者实践11条意见.     

非酒精性脂肪性肝病与常见内分泌代谢性疾病的关系及临床治疗综述

近年来,非酒精性脂肪性肝病(non-alcoholic?fatty?liver?disease,NAFLD)已成为我国第一大慢性肝病.与NAFLD相关的内分泌代谢性疾病的发病率也在逐年上升,其发病机制、病理生理学特征和临床后果较为复杂,被广泛研究.本文综述了NAFLD与临床上常合并的内分泌代谢性疾病的流行病学依据、病理生理学机制和治疗策略的研究现状,以期为NAFLD的临床管理提供更多方向.