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排序方式: 共有1094条查询结果,搜索用时 15 毫秒
41.
Sumit Thakar Sunil V. Furtado Nandita Ghosal A. S. Hegde 《Child's nervous system》2010,26(12):1819-1823
Introduction
Giant cavernous malformations (GCMs) constitute an uncommon entity in the diagnostic armamentarium of the neurosurgeon. We report a 3-year-old boy with a GCM in the peri-trigonal region and review 13 other paediatric cases previously reported in literature. 相似文献42.
Dipankar Ray Aarif Ahsan Abigail Helman Guoan Chen Ashok Hegde Susmita Ramanand Gurjar Lili Zhao Hiroaki Kiyokawa David G Beer Theodore S Lawrence Mukesh K Nyati 《Neoplasia (New York, N.Y.)》2011,13(7):570-578
Epidermal growth factor receptor (EGFR) is overexpressed in a variety of epithelial tumors and is considered to be an important therapeutic target. Although gene amplification is responsible for EGFR overexpression in certain human malignancies including lung and head and neck cancers, additional molecular mechanisms are likely. Here, we report a novel interaction of EGFR with an HECT-type ubiquitin ligase SMURF2, which can ubiquitinate, but stabilize EGFR by protecting it from c-Cbl-mediated degradation. Conversely, small interfering RNA (siRNA)-mediated knockdown of SMURF2 destabilized EGFR, induced an autophagic response and reduced the clonogenic survival of EGFR-expressing cancer cell lines, with minimal effects on EGFR-negative cancer cells, normal fibroblasts, and normal epithelial cells. UMSCC74B head and neck squamous cancer cells, which form aggressive tumors in nudemice, significantly lost in vivo tumor-forming ability on siRNA-mediated SMURF2 knockdown. Gene expressionmicroarray data from 443 lung adenocarcinoma patients, and tissue microarray data from 67 such patients, showed a strong correlation of expression between EGFR and SMURF2 at the messenger RNA and protein levels, respectively. Our findings suggest that SMURF2-mediated protective ubiquitination of EGFR may be responsible for EGFR overexpression in certain tumors and support targeting SMURF2-EGFR interaction as a novel therapeutic approach in treating EGFR-addicted tumors. 相似文献
43.
We report a case of acute bilateral central serous chorioretinopathy in a patient who received a local injection of triamcinolone for the treatment of plantar fasciitis. Central serous chorioretinopathy is a serious, though rare, ocular complication of steroid treatment and it may occur even when the steroid is administered at a site as remote from the eye as the foot. This case report highlights the need for greater awareness of this complication amongst all medical personnel who prescribe steroids. It is advisable that patients, undergoing steroid treatment for any cause, be alerted to the risk of sudden visual impairment. 相似文献
44.
The developmental stages of the middle phalanx of the third finger (MP3): a sole indicator in assessing the skeletal maturity? 总被引:1,自引:0,他引:1
Assessment of skeletal maturity is an integral part of interceptive diagnosis and treatment planning. The present day methods of skeletal maturity assessment like the hand-wrist radiographs or cervical vertebrae radiographs are expensive, require elaborate equipment and accounts for high radiation exposure, especially for growing children. The present study was thus undertaken to provide a simple and practical method of skeletal maturity assessment using the developmental stages of the middle phalanx of the third finger (MP3) as seen on an IOPA film taken using a standard dental x-ray machine. The results of the study showed that this simple method was highly reliable and could be used as an alternative method to assess the skeletal maturity of growing children. 相似文献
45.
Hegde RJ Parimala K Shivaprakash 《Journal of the Indian Society of Pedodontics and Preventive Dentistry》2003,21(1):42-44
Acute thrombocytopenic purpura is the most common of thrombocytopenias of the childhood. Clinical features include petechial lesions on oral mucosa, gingival bleeding and occasionally hemorrhage. A case of acute thrombocytopenic purpura is presented. 相似文献
46.
Trauma to the anterior teeth is relatively common among children and teenagers. Reattachment of a fractured fragment to the remaining tooth can provide better and long lasting esthetics, improved function, a positive psychological response and is a faster and less complicated procedure. This article discusses fragment reattachment technique and presents clinical case of coronal fracture involving enamel and dentin. 相似文献
47.
Dissection of the intracranial internal carotid artery producing isolated oculomotor nerve palsy with sparing of pupil 总被引:1,自引:0,他引:1
Dissection of the internal carotid artery usually occurs in the cervical segment, but rarely may involve the artery in the intracranial course (1). The clinical course of intracranial dissection is often catastrophic, with rapid onset of profound neurological deficit, as a result of middle and/or anterior cerebral artery involvement. When this occurs the mortality rate is generally considered high. We describe a case of intracranial internal carotid artery dissection following trivial trauma presented with an isolated painful pupillary sparing oculomotor nerve palsy. 相似文献
48.
Mahesh Chandra Hegde M. Panduranga Kamath Kiran Bhojwani Ranjith Peter Polisetti Ravi Babu 《Indian journal of otolaryngology and head and neck surgery》2005,57(1):35-38
Objective A climical study was undertaken to analyze the age, sex distribution and symptomatology, sites of involvement and the prognosis
of the common types of benign lesions of larynx.
Study Design A five year retrospective study from 1997 to 2002.
Setting KMC Hospital Attavar —A tertiary referral hospital.
Patients A total of 42 patients with benign laryngeal lesions were included based on symptomatology such as hoarseness of voice, foreign
body sensation, throat pain, neck mass and cough and with positive clinical findings on indirect laryngoscopy and neck examination.
The patients ranged from 7–80 years. All non-operative cases and malignant cases were excluded. Diagnostic hematological and
radiological investigations and therapeutic microlyryngoscopic procedures were employed.
Results A male preponderance with M:F ratio of 3∶1 was observed. Majority of the patients were in the 30–40 age group. Vocal polyps
were the commonest type of lesion. In our study, hoarseness of voice, cough, foreign body sensation and throat pain proved
to be the commonest symptoms.
Conclusions Micro laryngeal surgery and voice rest offer a cost effective, useful and safe method for management of benign laryngeal lesions. 相似文献
49.
A. M. Shenoy N. Grover N. Janardhan P NJayakumar T. Hegde S Satish 《Indian journal of otolaryngology and head and neck surgery》2002,54(4):274-279
This study is a retrospective analysis of 30 consecutive cases of Juvenile Nasopharyngeal Angiofibroma (JXA) operated at.
Department of Head and Neck Surgery, Kidwai Memorial Institute of Oncology Bangalore, India: la tertiary referral centre)
after prior emohilization by an interventional neuro-radiologisl (1996-2002). This study discusses critically the planning
of surgical approach, based on anatomico-radiological factors and highlights the efficacy of preoperalive embolization in
expediting total re moral of the tumor in 25 out of JO cases with advanced stage JNA.
Objectives: To analyze the utility of pre-operatire embolisation in surgical extirpation of large JNAs; planning of the surgical
approaches based on CT topography of the tumor; to study the various complications of embolisation and surgery associated
with JXA & lastly to evaluate the puttern and location of recurrent tumor thus correlating with the original topography.
Setting: Tertiary care cancer referral centre.
Patients: Patients ranged in age from ’)- 24 years. all being males.
Interventions: Majority of them were accessed by transfacial surgical approach(26). and in the recent past via midfacial degloving(4)
within 4H hours of angioembolisation.
Results: Complete removal of the tumor was achieved in 25 out of 30 cases with advanced stage JNA.
Post surgical CT scans revealed tumor residua in 5 individuals, where the tumor was documented in - the temporal fossa 12),
para-cavernous sinus region (I), cavernous sinus! I) and pterygo palatine fossa (I). Only the lesion in pterygopalaline fossa
was successfully re-i>xcised & this alongwith the recurrence at para-cavernous & cavernous sinus & another were treated with
radiotherapy; the 2 cases in the temporal fossa are under observation. The average blood loss during the procedure was 546.60
ml.
Conclusions: Today, advances in radiologie imaging-complemented by interventional neuro-radiological expertise in angio-embolisation
have expedited complète excision with minimal morbidity and acceptable recurrence rate. This study has justified pre-operative
embolisation and M currently the standard of care for advanced JXA. 相似文献
50.