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991.
Yamaguchi Kosei Kitamura Mineaki Takazono Takahiro Yamamoto Kazuko Hashiguchi Junichiroh Harada Takashi Funakoshi Satoshi Mukae Hiroshi Nishino Tomoya 《Clinical and experimental nephrology》2022,26(10):1022-1029
Clinical and Experimental Nephrology - Withdrawal from maintenance hemodialysis is unavoidable in some patients due to their poor general condition; however, their survival days vary depending on... 相似文献
992.
Hibino Satoshi Kitagata Ryoichi Nishimura Tatsuya Kagata Keiro Tanaka Kazuki Fujita Naoya 《Clinical and experimental nephrology》2022,26(2):198-204
Clinical and Experimental Nephrology - Some pediatric patients on maintenance dialysis may need end-of-life care in the future because of being excluded from the indication of kidney... 相似文献
993.
994.
p37 Induces tumor invasiveness 总被引:4,自引:0,他引:4
Ketcham CM Anai S Reutzel R Sheng S Schuster SM Brenes RB Agbandje-McKenna M McKenna R Rosser CJ Boehlein SK 《Molecular cancer therapeutics》2005,4(7):1031-1038
Previous studies have shown a statistically significant correlation between human carcinomas and monoclonal antibody detection of a Mycoplasma hyorhinis-encoded protein known as p37. A potential mechanism of p37 is that it might promote invasion and metastasis. Recombinant p37 enhanced the invasiveness of two prostate carcinoma and two melanoma cell lines in a dose-dependent manner in vitro, but did not have a significant effect on tumor cell growth. Furthermore, the increased binding to cell surfaces and the enhanced invasive potential of cancer cells from exposure to p37 could be completely reversed by preincubation of the cancer cells with an anti-p37 monoclonal antibody. Sequence comparisons, followed by three-dimensional molecular modeling, revealed a region of similarity between p37 and influenza hemagglutinin A, a sialic acid-binding protein that plays a critical role in viral entry. Binding of p37 to prostate carcinoma cells was found to be at least partially sialic acid dependent because neuraminidase treatment decreased this binding. Taken together, these observations suggest that M. hyorhinis can infect humans and may facilitate tumor invasiveness via p37. These results further suggest that p37 may be a molecular target for cancer therapy. 相似文献
995.
Yoshifumi Noda MD Satoshi Goshima MD PhD Kaori Tanaka MD Shinji Osada MD PhD Hiroyuki Tomita MD PhD Akira Hara MD PhD Yukio Horikawa MD PhD Jun Takeda MD PhD Kimihiro Kajita RT Haruo Watanabe MD Hiroshi Kawada MD Nobuyuki Kawai MD Masayuki Kanematsu MD Kyongtae T. Bae MD PhD 《Journal of magnetic resonance imaging : JMRI》2016,43(3):680-687
996.
Mitsutoshi Miyasaka Daisuke Tsurumaru Yusuke Nishimuta Yoshiki Asayama Satoshi Kawanami Eiji Oki Minako Hirahashi Hiroshi Honda 《Japanese journal of radiology》2016,34(12):786-794
Objective
To investigate the feasibility of diagnosing the invasion depth of early colorectal cancer (CRC) by quantitatively evaluating the basal indentation (BI)—i.e., the intestinal lateral deformity—in CT colonography (CTC).Materials and methods
34 early CRCs (13 Tis CRCs and 21 T1 CRCs) in 32 patients who underwent a preoperative CTC were retrospectively examined. Two radiologists calculated the depth of the BI on a computed tomographic air-contrast enema (CT enema) image, the depth of the BI due to the geometric function (BI-G) on a cross-sectional multiplanar reconstruction (CS-MPR) image, and the ratio of the BI to the BI-G (i.e., the “BI ratio”) for each lesion. The BI ratios of the Tis and T1 CRCs were compared.Results
The BI ratios were significantly higher in the T1 CRCs than in the Tis CRCs (p < 0.0001). The optimum cutoff value of the BI ratio for differentiating the T1 CRCs from the Tis CRCs was 1.64, with a sensitivity, specificity, and area under the curve of 90.5 %, 100 %, and 0.974, respectively.Conclusions
We have demonstrated for the first time that quantitatively evaluating the BI can improve the accuracy of diagnosis of early CRC invasion depth.997.
Kenji Ishido Katsuhiko Higuchi Satoshi Tanabe Mizutomo Azuma Tohru Sasaki Chikatoshi Katada Shouko Komori Kazushige Hayakawa Kei Hosoda Keishi Yamashita Natsuya Katada Wasaburo Koizumi 《Japanese journal of radiology》2016,34(1):35-42
Objectives
Whether chemoradiotherapy (CRT) is clinically beneficial for the management of postoperative recurrence of advanced gastric cancer remains unclear. We retrospectively studied treatment outcomes in patients who had unresectable localized recurrence after surgery for advanced gastric cancer and evaluated the safety and efficacy of CRT.Methods
The study group comprised 21 patients who received concurrent CRT for unresectable localized recurrence after undergoing R0 resection for stage II/III advanced gastric cancer. Localized recurrence was defined as a few or limited recurrent lesions.Results
The recurrence pattern was anastomotic recurrence in 7 patients, abdominal lymph-node recurrence in 12, and anastomotic recurrence plus abdominal lymph-node recurrence in 2. The median total dose of radiotherapy was 48.6 Gy (range 39.6–56.0), and the CRT completion rate was 100 % (21 of 21 patients). CRT-related grade 3 or higher toxicity comprised neutropenia in 33.3 % of patients and anorexia in 9.5 %. The response rate was 61.9 % (complete response 38.1 %, partial response 23.8 %). The median overall survival was 35.0 months.Conclusions
We conclude that CRT may become one treatment strategy for the management of unresectable localized recurrence after curative resection of advanced gastric cancer.998.
Yoko Maeda Keisuke Goto Yukiko Honda Naoto Kuroda Kazuhiro Sentani Wataru Yasui Tetsutaro Hayashi Jun Teishima Akio Matsubara Yuko Nakamura Naoyuki Toyota Makoto Iida Kazuo Awai 《Japanese journal of radiology》2016,34(4):307-311
Tubulocystic carcinoma of the kidney is rare and typically indolent. Our case involved an aggressive tubulocystic carcinoma as well as the radiological confirmation of its relation to papillary renal cell carcinoma. A 46-year-old male presented with renal multiloculated cysts with a solid part. On computed tomography and magnetic resonance imaging, the solid part showed the characteristics of papillary renal cell carcinoma. Contrast enhancement of the solid part was fluffy and sparse because of the coexistence of cysts. Perirenal fat invasion resulted in exophytic cysts, and renal-hilar cystic lymph node metastasis existed. The histopathological diagnosis was tubulocystic carcinoma associated with areas of papillary renal cell carcinoma and poorly differentiated carcinoma with metastasis. Our case suggests that the solid part enhancement of tubulocystic carcinoma tends to be fluffy and sparse, and exophytic cysts and cystic lymph nodes may show radiologically aggressive findings. 相似文献
999.
Hiroshi Doi Kazuhiro Kitajima Kazuhito Fukushima Yusuke Kawanaka Miya Mouri Satoshi Yamamoto Reiichi Ishikura Tomonori Terada Kazuma Noguchi Shozo Hirota 《Japanese journal of radiology》2016,34(5):349-355
Purpose
Our aim was to determine whether the maximum standardized uptake value (SUVmax) of the primary lesion demonstrated by [18F]-fluoro-2-deoxyglucose positron emission tomography/computed tomography (FDG-PET/CT) is associated with the prognosis of maxillary sinus cancer.Materials and methods
The relationships of clinicopathological factors including age, T stage, N stage, histologic type, treatment strategy, and primary tumor SUVmax with progression-free (PFS) and overall (OS) survival were evaluated using the log-rank test and Cox method in 31 patients with maxillary sinus cancer before combined superselective intra-arterial chemotherapy using high-dose cisplatin with concurrent radiotherapy, or radiotherapy alone.Results
The median duration of follow-up was 55.4 (range 9.7–72.6) months. PFS and OS of patients exhibiting a high SUVmax (≥16 and ≥17, respectively) for the primary tumor were significantly lower than those of patients for whom the primary tumor SUVmax was low (p = 0.0010 and p = 0.033, respectively). Multivariate analyses showed that T stage (p = 0.0049) and primary tumor SUVmax (p = 0.026) were independently prognostic of poorer PFS and that only primary tumor SUVmax (p = 0.049) was independently prognostic of poorer OS.Conclusion
SUVmax of the primary tumor determined by FDG-PET/CT before treatment could be a good surrogate marker for prognostication of maxillary sinus cancer.1000.
Satoshi Oki Mikihiro Inoue Kohei Otake Kohei Matsushita Yuhki Koike Keiichi Uchida Masato Kusunoki 《International journal of urology》2016,23(6):520-522
Bladder rupture in a fetus is a rare occurrence. We report the first neonatal case of laparoscopic repair for prenatally diagnosed bladder rupture. A male neonate, who had presented with megacystis, bilateral hydronephrosis and hydroureters since 27 weeks‐of‐gestation, was delivered by emergency cesarean section because of sudden collapse of the bladder with massive ascites at 37 weeks‐of‐gestation. The diagnosis of bladder rupture was made by retrograde urethrocystography. Laparoscopic repair was carried out subsequent to urethral catheterization. Intraoperatively, laceration from the left side of the bladder dome to the posterior wall was observed. This tear was successfully repaired using a two‐layer interrupted suture without any postoperative complications. Laparoscopic repair could be the treatment of choice for bladder rupture, because it has the advantage of closure of the perforated site more certainly than bladder decompression alone, and with better cosmesis than open repair. 相似文献