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Mustafa Sagit Ferhat Korkmaz Seren Gulsen Gürgen Mesut Kaya Alper Akcadag Ibrahim Ozcan 《American journal of otolaryngology》2014
Objective
To investigate the potential protective effect of thymoquinone in gentamicin-induced ototoxicity through auditory brain stem responses (ABR) testing and histomorphological evaluation of the cochlea.Methods
This study was conducted on 48 adult female Sprague–Dawley rats that were randomized into 4 groups. Group 1 received intraperitoneal gentamicin; group 2 received intraperitoneal gentamicin plus corn oil solution; group 3 received intraperitoneal thymoquinone; and group 4 received intraperitoneal gentamicin plus thymoquinone. All groups received the drugs (once daily) in the above-mentioned protocols over 15 days. After conducting repeated ABR measurements, the rats were sacrificed, and their cochleae were isolated.Results
ABR thresholds were preserved in the gentamicin plus thymoquinone group when compared with the group receiving gentamicin alone. There were fewer TUNEL-positive cells and caspase-3 and caspase-9 expressions were weaker in the inner and outer hairy cells of the organ of Corti in the gentamicin plus thymoquinone group compared with the group receiving gentamicin alone.Conclusion
The ABR values and number of apoptotic cells did not significantly increase in the group receiving gentamicin plus thymoquinone when compared to the group receiving gentamicin alone. Again, the cochlear histomorphological findings were supportive of the auditory findings. In light of these findings, we conclude that gentamicin-induced ototoxicity may be prevented by thymoquinone use in rats. 相似文献53.
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Antonietta Gentile Silvia Rossi Valeria Studer Caterina Motta Valentina De Chiara Alessandra Musella Helena Sepman Diego Fresegna Gabriele Musumeci Giorgio Grasselli Nabila Haji Sagit Weiss Liat Hayardeny Georgia Mandolesi Diego Centonze 《Journal of neuroimmune pharmacology》2013,8(3):651-663
Glutamate-mediated excitotoxicity is supposed to induce neurodegeneration in multiple sclerosis (MS). Glatiramer acetate (GA) is an immunomodulatory agent used in MS treatment with potential neuroprotective action. Aim of the present study was to investigate whether GA has effects on glutamate transmission alterations occurring in experimental autoimmune encephalomyelitis (EAE), to disclose a possible mechanism of GA-induced neuroprotection in this mouse model of MS. Single neuron electrophysiological recordings and immunofluorescence analysis of microglia activation were performed in the striatum of EAE mice, treated or not with GA, at different stages of the disease. GA treatment was able to reverse the tumor necrosis factor-α (TNF-α)-induced alterations of striatal glutamate-mediated excitatory postsynaptic currents (EPSCs) of EAE mice. Incubation of striatal slices of control animals with lymphocytes taken from EAE mice treated with GA failed to replicate such an anti-glutamatergic effect, while activated microglial cells stimulated with GA in vitro mimicked the effect of GA treatment of EAE mice. Consistently, EAE mice treated with GA had less microglial activation and less TNF-α expression than untreated EAE animals. Furthermore, direct application of GA to EAE slices replicated the in vivo protective activity of GA. Our results show that GA is neuroprotective against glutamate toxicity independently of its peripheral immunodulatory action, and through direct modulation of microglial activation and TNF-α release in the grey matter of EAE and possibly of MS brains. 相似文献
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Genetic characterization of avian influenza viruses isolated in Israel during 2000–2006 总被引:1,自引:0,他引:1
Golender N Panshin A Banet-Noach C Nagar S Pokamunski S Pirak M Tendler Y Davidson I García M Perk S 《Virus genes》2008,37(3):289-297
Our aim was to establish the phylogenetic and genetic relationships among avian influenza viruses (AIV) recently isolated
from poultry in Israel. During this study we analyzed complete nucleotide sequences of two envelope (hemagglutinin and neuraminidase)
and six internal genes (polymerase B1, polymerase B2, polymerase A, nucleoprotein, nonstructural, and matrix) of 29 selected
H9N2 and six internal genes of five H5N1 viruses isolated in Israel during 2000–2006. Comparative genetic and phylogenetic
analyses of these sequences revealed that the local H5N1 viruses are closely related to H5N1 viruses isolated in European,
Asian, and Middle Eastern countries in 2005–2006. The H9N2 Israeli isolates, together with viruses isolated in Jordan and
Saudi Arabia formed a single group. Our data support the claim that during recent years a new endemic focus of H9N2 has been
formed in the Middle East. The introduction of H5N1 and co-circulation of these two subtypes of AIV in this region may augment
the risk of potentially pandemic strains emergence. 相似文献
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Shushan S Sadan O Lurie S Evron S Golan A Roth Y 《American journal of perinatology》2006,23(7):431-433
Previous studies overestimated the incidence of pregnancy-associated rhinitis because it is a poorly defined clinical condition. The objective of this study was to assess the incidence of this unique type of rhinitis using up-to-date strict criteria. This prospective study included 109 primigravida parturients who were interviewed using a structured questionnaire and underwent detailed rhinoscopy. Pregnancy-associated rhinitis was defined as nasal obstruction symptom and rhinorrhea appearing during pregnancy, lasting for at least 2 months, and disappearing postpartum. The incidence of rhinitis associated with pregnancy at the time of delivery was 9%. No correlation was found between symptoms and signs. Pregnancy-associated rhinitis is an infrequent clinical entity. It may be related to hormonal changes and possibly altered sensation of nasal airflow. 相似文献
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Self-reported smile satisfaction: smile parameters and ethnic origin among Israeli male young adults
This study was undertaken to evaluate smile satisfaction among Israeli young males, to develop norms for young Israeli adults' smile parameters, and to determine whether there is a relationship between these parameters and par-ticipants' ethnic origin. The study population consisted of 403 Israeli young male adults. Participants were asked to report their ethnic origin, past orthodontic treatment and to grade their overall satisfaction from their own smile on a numerical scale of from 1 to 5. Smile parameter measurements were taken and the data analyzed. We concluded that there may be a common Jewish/Israeli norm of smile parameters. Consideration of the criteria of a smile obtained from this study may be useful in improving the esthetic value of prosthetic, restorative and orthodontic treatments. 相似文献