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11.
Effect of genetic modification of acute inflammatory responsiveness on tumorigenesis in the mouse 总被引:1,自引:3,他引:1
12.
Alfonso Mendoza-Velzquez Jonathan Lara-Arvalo Kennya Beatriz Siqueira Mariano Guzmn-Rodríguez Adam Drewnowski 《Nutrients》2022,14(20)
Affordable nutrient density is provided by low-cost and nutrient-rich foods. We explored nutrient density, cost, and NOVA category assignments within and across food groups in Brazil. The nutrient density of the foods (n = 591) was assessed using the Nutrient Rich Food Index (NRF9.3) based on protein, fiber, vitamin A (RAE), vitamin C, vitamin E (mg), Ca, Fe, K and Mg; and NRF6.3 score for priority nutrients: Ca, Fe, Zn, vitamin A, vitamin B12, and folate. Nutrients to limit (LIM) were saturated fat, added sugar, and sodium. Affordability was defined as the ratio of energy and/or nutrient density of foods and retail price per 100 kcal. Foods were classified as minimally processed (n = 106), processed (n = 188), ultra-processed (n = 286), and culinary ingredients (n = 11). Nutrient density was positively linked to per 100 kcal food cost. Ultra-processed foods (UPF) contained more energy, fat, sugar, and salt and had lower NRF scores compared to minimally processed (MPF) foods. UPF was also less expensive than MPF foods. Nutrient-rich foods below the median per 100 kcal costs included MPF foods, but also processed foods (PF) and UPF. Affordable nutrient-rich foods can be found in the different categories of the NOVA classification. 相似文献
13.
Alexandre de Matos Soeiro Bruno Biselli Tatiana C.A.T. Leal Aline Siqueira Bossa Maria Cristina Csar Srgio Jallad Priscila Gherardi Goldstein Patrícia Oliveira Guimares Carlos Vicente Serrano Jr Cesar Higa Nomura Dbora Nakamura Carlos Eduardo Rochitte Paulo Rogrio Soares Múcio Tavares de Oliveira Jr. 《Arquivos brasileiros de cardiologia》2022,118(5):894
BackgroundCoronary tomography angiography (CTA) has been mainly used for chest pain evaluation in low-risk patients, and few data exist regarding patients at intermediate risk.ObjectiveTo evaluate the performance of serial measures of sensitive troponin and CTA in intermediate-risk patients.MethodsA total of 100 patients with chest pain, TIMI risk scores of 3 or 4, and negative troponin were prospectively included. All patients underwent CTA and those with coronary stenosis ≥ 50% were referred to invasive coronary angiography. Patients with coronary lesions <50% were discharged and contacted 30 days later by a telephone call to assess clinical outcomes. Outcomes were hospitalization, death, and myocardial infarction at 30 days. The comparison between methods was performed by Kappa agreement test. The performance of troponin measures and CTA for detecting significant coronary lesions and clinical outcomes was calculated. Results were considered statistically significant when p < 0.05.ResultsCoronary stenosis ≥ 50% on CTA was found in 38% of patients and significant coronary lesions on coronary angiography were found in 31 patients. Two clinical events were observed. Kappa agreement analysis showed low agreement between troponin measures and CTA in the detection of significant coronary lesions (kappa = 0.022, p = 0.78). The performance of CTA for detecting significant coronary lesions on coronary angiography or for predicting clinical events at 30 days was better than sensitive troponin measures (accuracy of 91% versus 60%).ConclusionCTA performed better than sensitive troponin measures in the detection of significant coronary disease in patients with chest pain and intermediate risk for cardiovascular events. 相似文献
14.
15.
Dimytri A. Siqueira MD PHD Matheus Simonato MD Auristela A. Ramos MD PhD Tiago Bignoto MD PhD David Le Bihan MD PhD Rodrigo B. M. Barreto MD PhD Tiago Senra MD PhD Ibraim M. Pinto MD PhD Antonio M. Kambara MD PhD Magaly A. Santos MD PhD Renata Viana MD Amanda G. M. R. Sousa MD PhD Alexandre A. C. Abizaid MD PhD 《Catheterization and cardiovascular interventions》2021,97(1):167-174
16.
Caroline Louise Diniz Pereira Joelma Carvalho Santos Raissa Melo Arruda Milena Lima Rodrigues Eduardo Sampaio Siqueira Roberto Souza Lemos Andrea Dória Batista Ana Lúcia Coutinho Domingues Edmundo Pessoa Lopes 《Ultrasound in medicine & biology》2021,47(5):1235-1243
In patients with Mansoni schistosomiasis, it is fundamental to evaluate the disease morbidity, which is reflected by the severity of periportal fibrosis (PPF) and parameters of portal hypertension, as analyzed by ultrasonography (US). This study aimed to evaluate the morbidity of schistosomiasis by hepatic and splenic point shear-wave elastography (pSWE) and relate this to US parameters. The PPF pattern, the diameter of the portal and splenic veins and the size of the spleen were evaluated by US. Then, liver and spleen pSWEs were assessed in 74 patients using the same equipment. As the PPF pattern progressed, the splenic pSWE values significantly increased. Significant correlations between splenic pSWE, the longitudinal and transverse lengths of the spleen and the diameters of the portal and splenic veins were observed. These findings, however, were not observed through hepatic pSWE. In conclusion, the splenic pSWE has the potential for assessing morbidity in schistosomiasis mansoni. 相似文献
17.
Luciana Furlaneto-Maia Kátia Real Rocha Vera Lúcia Dias Siqueira Márcia Cristina Furlaneto 《Revista do Instituto de Medicina Tropical de S?o Paulo》2014,56(2):97-103
Enterococci are increasingly responsible for nosocomial infections
worldwide. This study was undertaken to compare the identification and
susceptibility profile using an automated MicrosScan system, PCR-based assay and
disk diffusion assay of Enterococcus spp. We evaluated 30
clinical isolates of Enterococcus spp. Isolates were identified
by MicrosScan system and PCR-based assay. The detection of antibiotic resistance
genes (vancomycin, gentamicin, tetracycline and erythromycin) was also
determined by PCR. Antimicrobial susceptibilities to vancomycin (30 µg),
gentamicin (120 µg), tetracycline (30 µg) and erythromycin (15 µg) were tested
by the automated system and disk diffusion method, and were interpreted
according to the criteria recommended in CLSI guidelines. Concerning
Enterococcus identification the general agreement between
data obtained by the PCR method and by the automatic system was 90.0% (27/30).
For all isolates of E. faecium and E. faecalis
we observed 100% agreement. Resistance frequencies were higher in E.
faecium than E. faecalis. The resistance rates
obtained were higher for erythromycin (86.7%), vancomycin (80.0%), tetracycline
(43.35) and gentamicin (33.3%). The correlation between disk diffusion and
automation revealed an agreement for the majority of the antibiotics with
category agreement rates of > 80%. The PCR-based assay, the
van(A) gene was detected in 100% of vancomycin resistant
enterococci. This assay is simple to conduct and reliable in the identification
of clinically relevant enterococci. The data obtained reinforced the need for an
improvement of the automated system to identify some enterococci. 相似文献
18.
Janine Braga de Souza Jacqueline de Souza Lara Maria Lopes de Castro Melissa Fabíola Siqueira Ranylson Marcello Leal Savedra 《Pharmaceutical development and technology》2019,24(3):283-292
This study aimed at evaluating the shake-flask use as a universal method to evaluate drug solubility in a biowaiver context as proposed by FDA, EMA and ANVISA. The solubility of losartan was determined in three buffers using the shake-flask method, intrinsic dissolution (ID) and Quantum Chemistry. Moreover, the evaluation of a losartan dissolution profile from coated tablets was conducted. The losartan low solubility in pH 1.2 and high solubility in pH 6.8 were observed using the shake-flask method. However, the solubility results using ID demonstrated its high solubility in pH 1.2 and 6.8. It was not possible to find conclusive results regarding the solubility of the drug in pH 4.5. The studies conducted by Quantum Chemistry provide molecular and electronic data that helped understand the losartan solvation in different pH values. Our experimental results defined that losartan can be classified as a low-solubility drug. In addition, this work shows that shake-flask cannot be a universal method of solubility studies in biowaiver context. Individual analysis will be necessary. The intrinsic dissolution should be considered as a complementary method. 相似文献
19.
Emilia Modolo Pinto Sheila A. C. Siqueira Priscilla Cukier Maria C. B. V. Fragoso Chin Jia Lin Berenice Bilharinho de Mendonca 《Pituitary》2011,14(4):400-404
Nelson’s syndrome (NS) is characterized by the appearance and/or progression of ACTH-secreting pituitary macroadenomas in
patients who had previously undergone bilateral adrenalectomy for the treatment of Cushing’s disease. Such corticotroph macroadenomas
respond poorly to currently available therapeutic options which include surgery, radiotherapy and chemotherapy. P53 protein
accumulation may be detected by immunohistochemistry in pituitary corticotroph adenomas and it has been suggested that it
might be causally related to tumor development. Wild type P53 protein plays an important role in the cellular response to
ionizing radiation and other DNA damaging agents and is mutated in many human tumors. In this study we report an adult male
patient with NS who underwent both transsphenoidal and transcranial pituitary surgeries, conventional and stereotaxic radiotherapy
and brachytherapy. Despite of the efforts to control tumor mass and growth, this macroadenoma displayed relentless growth
and aggressive behavior. DNA extracted from the first two surgical samples, as well as DNA from peripheral blood leukocytes
disclosed normal p53 sequence. DNA extracted from tumor samples obtained at surgeries performed after pituitary irradiation carried a somatic
heterozygous mutation, consisting of a deletion of four cytosines between nucleotides 12,144–12,149 in exon 4 of the p53 gene. This frameshift mutation creates a stop codon in exon 4 excluding the expression of a functional protein from the defective
allele. These data demonstrate a possible association between the P53 protein loss of function induced by radiotherapy and
the aggressive course of the disease in this patient. 相似文献
20.