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51.
Esther García Rojo Borja García Gómez Rocio Santos-Pérez de la Blanca Celeste Manfredi Manuel Alonso Isa José Medina Polo Alfredo Rodríguez Antolín Javier Romero Otero 《Asian journal of andrology》2021,(3):325-329
Neutrophil-to-lymphocyte ratio(NLR)and platelet-to-lymphocyte ratio(PLR)have been associated with multiple entities and several types of cancers.They can be ass... 相似文献
52.
Eduardo Martin-Sanz MD PhD Juan Riestra MD Laura Yebra MD Alba Larran MD Fiorella Mancino MD Joaquin Yanes-Diaz MD Maria Garrote MD Marta Colmenero MD Esther Montiel MD Cristina Molina MD Daniel Moreno MD Antonio Rodriguez MD PhD Gerardo Monedero MD Ricardo Sanz-Fernández MD PhD Rocio Gonzalez MD PhD Jonathan Esteban-Sanchez MD 《The Laryngoscope》2020,130(11):2674-2679
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Juan Carlos Molina Ruiz Jose Luis Guerrero Orriach Maria Luisa Bravo Arcas Angela Montilla Sans Rocio Escano Gonzalez 《World Journal of Clinical Cases》2022,10(8):2657-2659
In this letter to the editor, we would like to show in our hospital how our nurse team manage formation during coronavirus disease 2019 pandemic. 相似文献
55.
Joaquín Portilla óscar Moreno-Pérez Carmen Serna-Candel Corina Escoín Rocio Alfayate Sergio Reus Esperanza Merino Vicente Boix Livia Giner José Sánchez-Payá Antonio Picó 《Journal of the International AIDS Society》2014,17(1)
Introduction
Vitamin D insufficiency (VDI) has been associated with increased cardiovascular risk in the non-HIV population. This study evaluates the relationship among serum 25-hydroxyvitamin D [25(OH)D] levels, cardiovascular risk factors, adipokines, antiviral therapy (ART) and subclinical atherosclerosis in HIV-infected males.Methods
A cross-sectional study in ambulatory care was made in non-diabetic patients living with HIV. VDI was defined as 25(OH)D serum levels <75 nmol/L. Fasting lipids, glucose, inflammatory markers (tumour necrosis factor-α, interleukin-6, high-sensitivity C-reactive protein) and endothelial markers (plasminogen activator inhibitor-1, or PAI-I) were measured. The common carotid artery intima-media thickness (C-IMT) was determined. A multivariate logistic regression analysis was made to identify factors associated with the presence of VDI, while multivariate linear regression analysis was used to identify factors associated with common C-IMT.Results
Eighty-nine patients were included (age 42±8 years), 18.9% were in CDC (US Centers for Disease Control and Prevention) stage C and 75 were on ART. VDI was associated with ART exposure, sedentary lifestyle, higher triglycerides levels and PAI-I. In univariate analysis, VDI was associated with greater common C-IMT. The multivariate linear regression model, adjusted by confounding factors, revealed an independent association between common C-IMT and patient age, time of exposure to protease inhibitors (PIs) and impaired fasting glucose (IFG). In contrast, there were no independent associations between common C-IMT and VDI or inflammatory and endothelial markers.Conclusions
VDI was not independently associated with subclinical atherosclerosis in non-diabetic males living with HIV. Older age, a longer exposure to PIs, and IFG were independent factors associated with common C-IMT in this population. 相似文献56.
Anna L. Alimonda Julio Núñez Eduardo Núñez Oliver Husser Juan Sanchis Vicent Bodí Gema Miñana Rocio Robles Luis Mainar Pilar Merlos Helene Darmofal Ángel Llácer 《European Journal of Internal Medicine》2009,20(1):74-79
BackgroundHyperuricemia is a prevalent condition in chronic heart failure (CHF), describing increased oxidative stress and inflammation. Although there is evidence that serum uric acid (UA) predicts mortality in CHF, its role as a prognostic biomarker in acute heart failure (AHF) has not yet been well assessed. The aim of this study was to determine if UA levels predict all-cause mortality. Additionally, as a secondary endpoint we sought the clinical predictors of UA serum level in this population.MethodsWe analyzed 560 consecutive patients with AHF admitted in a single university center. UA (mg/dl) was measured during early hospitalization. Patient survival status was followed up after discharge (median follow-up: 330 days). The independent association of UA level with all-cause mortality was analyzed using Cox regression analysis.ResultsDuring follow-up 165 (29.5%) deaths were identified. Patients with UA levels above the median value (≥ 7.7 mg/dl) exhibited higher mortality rates (21.1 vs. 37.9%; p < 0.001). In multivariable analysis, after adjusting for recognized prognostic factors and potential confounders, UA ≥ 7.7 mg/dl and per change in 1 mg/dl of UA was associated with an increased risk of mortality (HR 1.45, CI 95% = 1.03–2.44; p = 0.03 and HR 1.08, CI 95% = 1.01–1.15; p = 0.03, respectively).ConclusionUA serum levels is an independent predictor of all-cause mortality in an unselected patients admitted with AHF. 相似文献
57.
Ravelli A Duarte-Salazar C Buratti S Reiff A Bernstein B Maldonado-Velazquez MR Beristain-Manterola R Maeno N Takei S Gerloni V Spencer CH Pratsidou-Gertsi P Ruperto N Pistorio A Martini A 《Arthritis and rheumatism》2003,49(4):501-507
OBJECTIVE: To investigate the prevalence of cumulative organ damage in patients with juvenile-onset systemic lupus erythematosus (SLE) and its association with demographic and clinical variables, medication use, and quality of life. METHODS: The occurrence of organ system damage, as measured by the Systemic Lupus International Collaborating Clinics/American College of Rheumatology Damage Index (SDI), was determined for 387 patients consecutively enrolled in pediatric rheumatology centers from Europe, the US, Mexico, and Japan. Risk factors for damage included demographic variables; clinical manifestations at diagnosis; previous corticosteroid, immunosuppressive, and antimalarial therapies; disease activity; and quality of life. RESULTS: Overall, 195 (50.5%) patients had damage within a mean of 5.7 years after disease onset. Renal (21.8%) and neuropsychiatric (15.8%) system involvement were observed most frequently, followed by musculoskeletal (11.7%), ocular (10.9%) and skin (9.6%) system involvement, with a mean SDI score of 1.1. In multivariate models, the occurrence of neuropsychiatric manifestations at diagnosis, a longer disease duration, and a greater number of intravenous cyclophosphamide pulses showed the strongest association with the presence of damage. CONCLUSION: We found evidence of cumulative organ damage, as measured by the SDI, in half of the patients with juvenile-onset SLE. Damage was significantly more likely in patients who had experienced neuropsychiatric manifestations at diagnosis, had a longer disease duration, and had received more intravenous pulses of cyclophosphamide. 相似文献
58.
Arteaga M Chavarría A Morales Montor J 《Revista de investigación clínica; organo del Hospital de Enfermedades de la Nutrición》2002,54(6):542-549
The complex communication between the immune and neuroendocrine systems is bi-directional, and involves sharing different ligands and receptors in tissues and organs in vertebrate in general, and mammals in particular. It have been demonstrated that many hormones, neurohormones and neurotransmitters have profound effects on the immune system, and in turn, cytokines produced by cells of the immune system cause important changes in the neuroendocrine function. It has been shown in different animal models with induced and spontaneously occurring autoimmune diseases that alterations of the immunoendocrine interactions are involved in the breakdown of self tolerance, and by extend, the homeostasis. This review discusses the role of the neuroimmunoendocrine interactions in maintaining the homeostasis of mammals, and their role in the development of some autoimmune diseases. The finding that could exist a defective immunoneuroendocrine communication may lead to more specific therapy of several autoimmune human diseases. 相似文献
59.
We treated 74 adults with a hematological malignancy and documented or suspected invasive fungal infection (IFI) with amphotericin B lipid complex (ABLC) at 3 mg/kg/day. Forty-five patients (61%) received upfront therapy and 29 patients (39%) received salvage therapy for their IFI. Forty-eight of 71 evaluable patients responded [complete responses in 40 (56%) and partial responses in 8 (11%)] and 15 (21%) died as a consequence of the IFI. Response rates in invasive aspergillosis were 33 out of 49 (67%) for probable/definite cases and 6 out of 11 (55%) for invasive candidiasis. In 40 patients with neutropenia-associated IFI, rapid neutropenic recovery ( < 10 days from study entry) was essential for response to therapy (90% vs. 32%, P < 0.01). Treatment was well tolerated, with 15% infusions followed by infusion-related adverse events, nephrotoxicity in 7% of patients and 11% of withdrawals due to toxicity. These data suggest that intermediate-doses of ABLC may be of similar efficacy than higher doses with less toxicity, making it a cost-effective alternative worthy of study in future trials. 相似文献
60.