全文获取类型
收费全文 | 11112篇 |
免费 | 766篇 |
国内免费 | 61篇 |
专业分类
耳鼻咽喉 | 85篇 |
儿科学 | 342篇 |
妇产科学 | 213篇 |
基础医学 | 1295篇 |
口腔科学 | 303篇 |
临床医学 | 887篇 |
内科学 | 2770篇 |
皮肤病学 | 194篇 |
神经病学 | 478篇 |
特种医学 | 211篇 |
外国民族医学 | 5篇 |
外科学 | 1375篇 |
综合类 | 531篇 |
一般理论 | 4篇 |
预防医学 | 1160篇 |
眼科学 | 244篇 |
药学 | 1069篇 |
中国医学 | 134篇 |
肿瘤学 | 639篇 |
出版年
2023年 | 143篇 |
2022年 | 359篇 |
2021年 | 572篇 |
2020年 | 295篇 |
2019年 | 390篇 |
2018年 | 366篇 |
2017年 | 289篇 |
2016年 | 353篇 |
2015年 | 373篇 |
2014年 | 461篇 |
2013年 | 576篇 |
2012年 | 943篇 |
2011年 | 933篇 |
2010年 | 492篇 |
2009年 | 406篇 |
2008年 | 628篇 |
2007年 | 534篇 |
2006年 | 549篇 |
2005年 | 529篇 |
2004年 | 426篇 |
2003年 | 380篇 |
2002年 | 333篇 |
2001年 | 162篇 |
2000年 | 148篇 |
1999年 | 147篇 |
1998年 | 75篇 |
1997年 | 59篇 |
1996年 | 57篇 |
1995年 | 51篇 |
1994年 | 38篇 |
1993年 | 44篇 |
1992年 | 80篇 |
1991年 | 57篇 |
1990年 | 58篇 |
1989年 | 78篇 |
1988年 | 50篇 |
1987年 | 48篇 |
1986年 | 53篇 |
1985年 | 40篇 |
1984年 | 36篇 |
1983年 | 33篇 |
1982年 | 31篇 |
1981年 | 24篇 |
1980年 | 19篇 |
1979年 | 27篇 |
1977年 | 19篇 |
1975年 | 19篇 |
1973年 | 21篇 |
1972年 | 16篇 |
1970年 | 15篇 |
排序方式: 共有10000条查询结果,搜索用时 0 毫秒
91.
Gin Gin GanKevin Wen Fei TeySumaiyah MatMarniza SaadPing Chong BeeRozita Abdul MalikGwo Fuang HoChong Guan Ng 《Asian Pacific journal of cancer prevention》2022,23(11):3905-3914
Background: Quality of life (QOL) of family caregivers of cancer patients is usually affected due to increase in caregiver burden. Their QOL has not garnered much attention by many including the health professionals and community. This study aims to explore the QOL of family caregivers of cancer patients in a multi-ethnic country in Asia and to investigate its associate factors. Methods: This is a cross-sectional study where family caregivers and patients who were diagnosed of cancers within 12 months were recruited. QOL of caregivers were measured using The Caregiver Quality of Life Index-Cancer (CQOLC). Psychological distress was measured using Hospital anxiety and depressive scale. Logistic regression analysis was performed to determine the related factors of QOL of caregivers. Results: A total of 458 patients/caregiver pairs were included. Symptoms of anxiety and depression reported by caregivers were 24.9% and 24.2% respectively. Caregivers of patients with solid tumors have better CQOLC score compared to those who cared for patients with hematological cancers (91.25 vs 86.75). Caregivers of non-Malay ethnicity, those caring for patients with advanced stage cancer and with hematological cancers had significantly poorer QOL. QOL of caregivers are also significantly affected when patients demonstrated anxiety symptoms. Conclusion: This study provides detailed evaluation of the QOL of caregivers of cancer patients in Malaysia. The significant psychological distress and low caregiver QOL indicate the urgent need for comprehensive supports for caregivers with cancer patients, especially those caring for patients with haematological cancers. 相似文献
92.
93.
Bisma Parveez Nur Ayuni Jamal Hazleen Anuar Yusilawati Ahmad Abdul Aabid Muneer Baig 《Materials》2022,15(15)
Metal foams possess remarkable properties, such as lightweight, high compressive strength, lower specific weight, high stiffness, and high energy absorption. These properties make them highly desirable for many engineering applications, including lightweight materials, energy-absorption devices for aerospace and automotive industries, etc. For such potential applications, it is essential to understand the mechanical behaviour of these foams. Producing metal foams is a highly challenging task due to the coexistence of solid, liquid, and gaseous phases at different temperatures. Although numerous techniques are available for producing metal foams, fabricating foamed metal still suffers from imperfections and inconsistencies. Thus, a good understanding of various processing techniques and properties of the resulting foams is essential to improve the foam quality. This review discussed the types of metal foams available in the market and their properties, providing an overview of the production techniques involved and the contribution of metal foams to various applications. This review also discussed the challenges in foam fabrications and proposed several solutions to address these problems. 相似文献
94.
Fouad Damiri Swetha Andra Nagavendra Kommineni Satheesh Kumar Balu Raviteja Bulusu Amira A. Boseila Damilola O. Akamo Zubair Ahmad Farhat S. Khan Md. Habibur Rahman Mohammed Berrada Simona Cavalu 《Materials》2022,15(15)
Water contamination is one of the most urgent concerns confronting the world today. Heavy metal poisoning of aquatic systems has piqued the interest of various researchers due to the high toxicity and carcinogenic consequences it has on living organisms. Due to their exceptional attributes such as strong reactivity, huge surface area, and outstanding mechanical properties, nanomaterials are being produced and employed in water treatment. In this review, recent advances in the use of nanomaterials in nanoadsorptive membrane systems for wastewater treatment and heavy metal removal are extensively discussed. These materials include carbon-based nanostructures, metal nanoparticles, metal oxide nanoparticles, nanocomposites, and layered double hydroxide-based compounds. Furthermore, the relevant properties of the nanostructures and the implications on their performance for water treatment and contamination removal are highlighted. The hydrophilicity, pore size, skin thickness, porosity, and surface roughness of these nanostructures can help the water permeability of the nanoadsorptive membrane. Other properties such as surface charge modification and mechanical strength can improve the metal adsorption effectiveness of nanoadsorptive membranes during wastewater treatment. Various nanocomposite membrane fabrication techniques are also reviewed. This study is important because it gives important information on the roles of nanomaterials and nanostructures in heavy metal removal and wastewater treatment. 相似文献
95.
Endothelins and their inhibition in the human skin microcirculation: ET[1-31], a new vasoconstrictor peptide 下载免费PDF全文
Leslie SJ Rahman MQ Denvir MA Newby DE Webb DJ 《British journal of clinical pharmacology》2004,57(6):720-725
AIMS: Endothelin-1 (ET-1([1-21])) is an extremely potent vasoconstrictor in the human skin microcirculation and is generated from larger precursor peptides. The aims of the present study were to assess the vasoactive effects of these precursors as well as endothelin blockade in the human skin microcirculation, in vivo. METHODS: Six healthy volunteers received intradermal injections of a range of doses of big ET-1([1-38]), ET-1([1-31]), ET-1([1-21]), BQ-123 (ET(A) receptor antagonist), BQ-788 (ET(B) receptor antagonist), phosphoramidon [endothelin converting enzyme (ECE) inhibitor] or saline control (0.9%). Skin blood flow (SBF) was measured using standard laser Doppler flowmetry. RESULTS: Big ET-1([1-38]), ET-1([1-31]) and ET-1([1-21]) reduced SBF when compared with saline control (P < 0.01 for all). Big ET-1([1-38]) and ET-1([1-31]) were less potent than ET-1([1-21]) as defined by skin vasoconstriction. Phosphoramidon, BQ-123 and BQ-788, given alone, all caused vasodilatation in the human skin microcirculation (P < 0.01 for all). CONCLUSIONS: In the human skin microcirculation, big ET-1([1-38]) and ET-1([1-31]) are less potent vasoconstrictors than ET-1([1-21]). The effects of big ET-1([1-38]) and phosphoramidon suggest the presence of endogenous ECE activity in the skin. In contrast to skeletal muscle resistance vessels, ET-1([1-21]) contributes to the maintenance of skin microvascular tone through both ET(A) and ET(B) receptor-mediated vasoconstriction. 相似文献
96.
97.
Mehzabeen Rahman Mohita Sharma Pragati Aggarwal Silkee Singla Neha Jain 《Indian journal of ophthalmology》2022,70(7):2272
Homocystinuria is a rare metabolic inborn disorder caused due to dysfunctional cystathionine β-synthase (CBS) enzyme activity, thus resulting in elevated levels of methionine and homocysteine in the blood and urine. The timely recognition of this rare metabolic disorder and prompt methionine-restricted diet are crucial in lessening the systemic consequences. The recalcitrant cases have a higher risk for cardiovascular diseases, neurodegenerative diseases, neural tube defects, and other severe clinical complications. This review aims to present the ophthalmic spectrum of homocystinuria and its molecular basis, the disease management, as well as the current and potential treatment approaches with a greater emphasis on preventive strategies. 相似文献
98.
Carmen W. E. Embregts Elmoubashar A. B. A. Farag Devendra Bansal Marjan Boter Anne van der Linden Vincent P. Vaes Ingeborg van Middelkoop-van den Berg Jeroen. IJpelaar Hisham Ziglam Peter V. Coyle Imad Ibrahim Khaled A. Mohran Muneera Mohammed Saleh Alrajhi Md. Mazharul Islam Randa Abdeen Abdul Aziz Al-Zeyara Nidal Mahmoud Younis Hamad Eid Al-Romaihi Mohammad Hamad J. AlThani Reina S. Sikkema Marion P. G. Koopmans Bas B. Oude Munnink Corine H. GeurtsvanKessel 《Viruses》2022,14(12)
Rabies virus (RABV) has a broad host range and infects multiple cell types throughout the infection cycle. Next-generation sequencing (NGS) and minor variant analysis are powerful tools for studying virus populations within specific hosts and tissues, leading to novel insights into the mechanisms of host-switching and key factors for infecting specific cell types. In this study we investigated RABV populations and minor variants in both original (non-passaged) samples and in vitro-passaged isolates of various CNS regions (hippocampus, medulla oblongata and spinal cord) of a fatal human rabies case, and of multiple CNS and non-CNS tissues of experimentally infected mice. No differences in virus populations were detected between the human CNS regions, and only one non-synonymous single nucleotide polymorphism (SNP) was detected in the fifth in vitro passage of virus isolated from the spinal cord. However, the appearance of this SNP shows the importance of sequencing newly passaged virus stocks before further use. Similarly, we did not detect apparent differences in virus populations isolated from different CNS and non-CNS tissues of experimentally infected mice. Sequencing of viruses obtained from pharyngeal swab and salivary gland proved difficult, and we propose methods for improving sampling. 相似文献
99.
Lakshmi Palukuri Raja Kiran Kumar Goud Ireni Faiyaz Abdul Jabbar Shaleena Sukumaran Nair Pranav Reddy Jambula Vijaybabu Kommu 《Indian Journal of Plastic Surgery》2022,55(4):383
Background Reconstruction of large foot and ankle defects is a difficult task due to less available local soft tissue and more critical from functional point of view. To overcome the limitations associated with locoregional flaps and free flaps, reverse peroneal artery (RPA) flap was selected and its usefulness in reconstruction of distal large defects of the ankle and foot and its complications were studied. Materials and Methods This is a prospective observational study done in 20 patients treated as cohort within 2 years and 8 months from January 2018 to August 2020. Large defects of foot and ankle were reconstructed with RPA flap and evaluated for its usefulness. Three cases were evaluated with computed tomography angiography postoperatively, to assess the vascular pattern. Conclusion RPA flap is a versatile and very reliable flap for the reconstruction of large and distal defects of foot and ankle. It is safely done in children and in acute trauma without any major complications. 相似文献
100.
Kerry L. Shannon Timothy Shields Sabeena Ahmed Hafizur Rahman Chai Shwai Prue Jacob Khyang Malathi Ram M. Zahirul Haq Jasmin Akter Mohammad Shafiul Alam Gregory E. Glass Myaing M. Nyunt David A. Sack David J. Sullivan Jr. Wasif A. Khan Frank C. Curriero 《The American journal of tropical medicine and hygiene》2022,107(6):1210