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排序方式: 共有2309条查询结果,搜索用时 15 毫秒
41.
Mehra Nikita Christopher Vasanth Dhanushkodi Manikandan Radhakrishnan Venkatraman Ganesan Trivadi S Ganesharajah Selvaluxmy Sagar Tenali Gnana Ganesan Prasanth 《International journal of clinical pharmacy》2020,42(2):662-666
International Journal of Clinical Pharmacy - Background There is limited data on specific antiemetic protocols for control of chemotherapy-induced nausea/vomiting (CINV) caused by weekly cisplatin... 相似文献
42.
Kaela Drzewiecki Jungmin Choi Joseph Brancale Michael A. Leney-Greene Sinan Sari Buket Dalgi Aysel Ünlüsoy Aksu Gülseren Evirgen ahin Ahmet Ozen Safa Baris Elif Karakoc-Aydiner Dhanpat Jain David Kleiner Michael Schmalz Kadakkal Radhakrishnan Junhui Zhang Kasper Hoebe Helen C. Su Joo P. Pereira Michael J. Lenardo Richard P. Lifton Sílvia Vilarinho 《The Journal of experimental medicine》2021,218(7)
43.
CABARKAPA Sonja Sadhu Raja King Joel Dowling Nathan Radhakrishnan Raghavakurup Akinbiyi Akinsola Srinivasaraju Ravindra Stevenson Dean 《The Psychiatric quarterly》2021,92(1):229-237
Psychiatric Quarterly - Patients who abscond from acute inpatient psychiatric wards put themselves and others at risks of variable nature and severity. There is a limited understanding of what... 相似文献
44.
Exosomes are small membrane vesicles of endocytic origin with a size of 50–100 nm. They can contain microRNAs, mRNAs, DNA fragments, and proteins, which are shuttled from a donor cell to recipient cells. Many different cell types including immune cells, mesenchymal cells, and cancer cells release exosomes. There is emerging evidence that cancer-derived exosomes contribute to the recruitment and reprogramming of constituents associated with tumor environment. Here, we discuss different mechanisms associated with biogenesis, payload, and transport of exosomes. We highlight the functional relevance of exosomes in cancer, as related to tumor microenvironment, tumor immunology, angiogenesis, and metastasis. Exosomes may exert an immunosuppressive function as well as trigger an anti-tumor response by presenting tumor antigens to dendritic cells. Exosomes may serve as cancer biomarkers and aid in the treatment of cancer. 相似文献
45.
Biswas Mainak Saba Luca Omerzu Tomaž Johri Amer M. Khanna Narendra N. Viskovic Klaudija Mavrogeni Sophie Laird John R. Pareek Gyan Miner Martin Balestrieri Antonella Sfikakis Petros P Protogerou Athanasios Misra Durga Prasanna Agarwal Vikas Kitas George D Kolluri Raghu Sharma Aditya Viswanathan Vijay Ruzsa Zoltan Nicolaides Andrew Suri Jasjit S. 《Journal of digital imaging》2021,34(3):581-604
Journal of Digital Imaging - Cardiovascular diseases (CVDs) are the top ten leading causes of death worldwide. Atherosclerosis disease in the arteries is the main cause of the CVD, leading to... 相似文献
46.
Radhakrishnan Sabarinathan Hakim Tafer Stefan E. Seemann Ivo L. Hofacker Peter F. Stadler Jan Gorodkin 《Human mutation》2013,34(4):546-556
Structural characteristics are essential for the functioning of many noncoding RNAs and cis‐regulatory elements of mRNAs. SNPs may disrupt these structures, interfere with their molecular function, and hence cause a phenotypic effect. RNA folding algorithms can provide detailed insights into structural effects of SNPs. The global measures employed so far suffer from limited accuracy of folding programs on large RNAs and are computationally too demanding for genome‐wide applications. Here, we present a strategy that focuses on the local regions of maximal structural change between mutant and wild‐type. These local regions are approximated in a “screening mode” that is intended for genome‐wide applications. Furthermore, localized regions are identified as those with maximal discrepancy. The mutation effects are quantified in terms of empirical P values. To this end, the RNAsnp software uses extensive precomputed tables of the distribution of SNP effects as function of length and GC content. RNAsnp thus achieves both a noise reduction and speed‐up of several orders of magnitude over shuffling‐based approaches. On a data set comprising 501 SNPs associated with human‐inherited diseases, we predict 54 to have significant local structural effect in the untranslated region of mRNAs. RNAsnp is available at http://rth.dk/resources/rnasnp . 相似文献
47.
Huperzine A (HupA) is an alkaloidal natural product and drug isolated from Chinese herb Huperzia serrata, which is a potent selective anticholinesterase inhibitor. HupA has symptomatic, cognitive-enhancing and protective effect on neurons against amyloid beta-induced oxidative injury and antagonizing N-methyl-d-aspartate receptors by blocking the ion channels. The present study aimed to identify the docking, ADME/T and molecular dynamics simulation parameters of a library of 40 analogues which can correlate the binding affinity, conformational stability and selectivity of the ligands towards NMDA receptor through in silico approach. Glide molecular docking analysis was performed for the designed analogues to understand the binding mode and interactions. MD simulations were performed to explain the conformational stability and natural dynamics of the interaction in physiological environmental condition of protein–ligand complex affording a better understanding of chemical-scale interactions between HupA and its analogues with NMDA channel that could potentially benefit the development of new drugs for neurodegenerative diseases involving NMDA receptors.The in silico study explores the structural behavior and binding affinities of 40 novel analogues of huperzine A. Novel NMDA receptor antagonists have been virtually identified by molecular docking, ADME/T and molecular dynamics simulation studies. 相似文献
48.
49.
Tarun Bali Raghu Nagraj Malhar N Kumar Thomas Chandy 《Indian Journal of Orthopaedics》2015,49(6):615-619
Background:
The treatment of anterior cruciate ligament (ACL) injury consists of arthroscopic ACL reconstruction with patellar tendon or hamstring graft. Satisfactory results have been reported so far in the younger age group. Dilemma arises regarding the suitability of ACL reconstruction in patients aged 50 years and above. This retrospective analyses the outcome of ACL reconstruction in patients aged 50 years and above.Materials and Methods:
55 patients aged 50 years and above presented to our institution with symptomatic ACL tear and were managed with arthroscopic reconstruction with patellar tendon/hamstring graft. 22 patients underwent ACL reconstruction with bone- patellar tendon-bone graft and the remaining 33 with a hamstring graft. Evaluation of functional outcome was performed using International Knee Documentation Committee (IKDC) and Lysholm scoring in the preoperative period, at the end of 1 year and at the final followup. Radiographic evaluation was performed using the Kellgren–Lawrence grading system.Results:
The mean preoperative IKDC score was 39.7 ± 3.3. At the end of 1-year following the operation, the mean IKDC score was 73.6 ± 4.9 and at the final followup was 67.8 ± 7.7. The mean preoperative Lysholm score was 40.4 ± 10.3. At the end of 1-year following the intervention, the mean Lysholm score was 89.7 ± 2.1 and at final followup was 85.3 ± 2.5. Overall, 14 out of 42 patients who underwent radiographic assessment showed progression of osteoarthritis changes at the final followup after the intervention.Conclusion:
In our study, there was a statistically significant improvement in the IKDC and Lysholm scores following the intervention. There was a slight deterioration in the scores at the final followup but the overall rate of satisfaction was still high and most of the patients were able to do their routine chores and light exercises suitable for their age group. Around one-third of patients show progression of radiographic changes in the postoperative period and this requires long term evaluation. 相似文献50.