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Four cases of thrombotic thrombocytopenic purpura have been used in thisstudy. The typical vascular lesions associated with this syndrome were presentin all instances. They consistently disclosed an accumulation of acidic polysaccharide similar to chondroitin sulfate or hyaluronic acid. This is presentedas further evidence for a primary alteration of the vessel walls in this disease. Submitted on June 4, 1959 Accepted on July 11, 1959 相似文献
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Newborn rabbits were rendered acutely anoxic by insertion intoan atmosphere of nitrogen and their respiratory movements wererecorded by direct observation and by an impedance pneumograph.The respiratory response comprised periods of dyspnoea, preterminalapnoea, gasping, and terminal apnoea. The duration of preterminalapnoea was increased at the expense of the period of gaspingby the prior administration of morphine or pethidine in a dosageinsufficient to cause important respiratory depression in air,survival not being shortened. 相似文献
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The endocrine and metabolic response to anaesthesia and surgery was studied in 12 men and eight women undergoing elective total hip replacement using buprenorphine as the intra- and postoperative analgesic. Plasma glucose, cortisol and prolactin were measured, and the results obtained for men and women compared. Statistically significant differences between men and women were found for prolactin during and after operation, and also for cortisol postoperatively. Men, but not women, demonstrated a significant fall in plasma cortisol following a dose of buprenorphine after operation. These results are discussed in relation to known procedures for ablating the stress response and to the neuroendocrine effects of opiate agonists and partial agonists. 相似文献