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31.
32.
D. S. Grewal Bachi Mistry Ninad Gaikwad 《Indian journal of otolaryngology and head and neck surgery》1995,47(2):106-112
Otogenic abscesses are the result of acute or chronic suppurative inflammation of the middle ear cleft caused by pus forming
organisms, which lead to extracranial or intracranial abscesses. When it leads to intracranial abscesses, it may be life-
threatening. Otogenic abscesses are commoner in India than in the Western countries due to many factors which have been discussed
in this paper.
Here we publish a study of fifty cases of otogenic abscesses with reference to our experience of their presentation and management. 相似文献
33.
34.
Two sisters (3 and 5-years-old) with acquired syphilis (genital ulcers) are reported. Presentation and probable mode of transmission
is discussed. Patients were diagnosed due to high index of suspicion. 相似文献
35.
A brief report of twenty cases of bilateral cauterization of the Vidian Nerve Canals in intractable non-atopic chronic Vasomotor Rhinitis by a Trans-Nasal approach not previously described is given. The authors find this approach to be a much safer and simpler procedure than either the Trans-Septal or the Trans-Antral routes. The advantages of this approach to the Vidian Nerve Canal over the Trans-Septal and Trans-Antral routes are discussed. 相似文献
36.
Wadekar MP Rode CV Bendale YN Patil KR Gaikwad AB Prabhune AA 《Journal of pharmaceutical and biomedical analysis》2006,41(4):1473-1478
The preparation method of metal based Indian traditional drugs involves conversion of a pure metal into its oxide by repeated high temperature calcination cycles. In this work, the effect of number of calcination cycles followed in the preparation of tin oxide based Ayurvedic drug, 'vanga bhasma' was studied by a systematic characterization of the drug samples after various calcination stages. It was found that tin was in the form of Sn4+ state and that the formation of SnO2 proceeded step-wise through Sn(OH)4. 相似文献
37.
Summary Most central neurocytomas (CN) and spinal neurocytomas (SN) have a bland well-differentiated histologic picture and uneventful clinical course. However, rare examples showing histologic atypia, recurrence and even CSF dissemination have been reported. Herein we report a case of recurrent spinal neurocytoma in a 24-year-old male who presented with a 2-month history of weakness and numbness of the left upper and lower limbs, and was previously operated at the same site 10 months ago. MRI revealed a contrast enhancing intramedullary mass involving C5-T1 region. Radiologic and operative impression at both surgeries was that of a glioma, possibly anaplastic. Histologic and immunohistochemical features in both resections were those of an atypical neurocytoma. The tumor showed rare mitoses, focal mild vascular proliferation in both specimens, and necrosis in the initial specimen. MIB1 labeling indices were 9 and 10%, respectively. Based on the analysis of this case and limited data from the literature, it is hypothesized that SN shows a histopathologic picture, immunoprofile and biologic behavior very similar to CN. However, the presence of histologic atypia and increased MIB1 index in SN appear to more closely correlate with tumor recurrence and a worse overall outcome, in part due to their location in the critical region of cervical spinal cord. Therefore, we hypothesize that SN with atypia requires a close clinical follow up. As in CN, radiation therapy is perhaps best reserved for atypical, progressive and recurrent SN. 相似文献
38.
DS Howale A Mishra AK Asthana D Sharma PG Gaikwad 《Journal of the Anatomical Society of India》2012,61(2):258-261
Biologists and physical anthropologists attempted to classify human being into races according to phenotypic variations. The latter are based either on one or two phenotypic characters therefore the outcome is unable to givq clear distinction among different races. Cranial index seems to be an important,tool, which may be used to identify the races in different geographical regions. 75 dried skulls collected from different part of Maharashtra were measured to determine the cranial index. Skulls were classified by the method of Montagu (1960)2 Average maximum cranial length and breadth were found to be 17.11 cm and 12.98 cm respectively and maximum & minimum cranial lengths were observed to be 18.50 and 16.60 cm and cranial breadths were noted to be 14.50 and 12.10 cm respectively. Average cranial index (mean ± SD) was 75.49 ± 3.95. In our study most of the skulls were grouped under the Mesocranial (46.66%) and Dolichocranial (42.66%) categorises when based on Montagu and Dolichocranial categorises when 56% based Comas'. As per the conclusion Maharashtrian population belongs to Indo-Dravidian race. 相似文献
39.
Specific metabolites of estrogens, catechol estrogen-3,4-quinones, if produced in relatively large amounts, can become chemical carcinogens by reacting with DNA to form predominantly depurinating DNA adducts. Estradiol (E2)-3,4-quinone (Q) reacts with DNA to form predominantly the depurinating DNA adducts, 4-hydroxyestradiol (OHE2)-1-N3Ade and 4-OHE 2-1-N7Gua. The depurinating adducts induce mutations by error-prone repair. We have conducted a study in which selected natural chemopreventing agents, N-acetylcysteine (NAcCys), melatonin, reduced lipoic acid, and resveratrol, have been tested for their ability to prevent the reaction of E(2)-3,4-Q with DNA. When DNA was incubated with E(2)-3,4-Q or lactoperoxidase-activated 4-OHE2 in the presence of an antioxidant, the formation of the N3Ade and N7Gua adducts was reduced. E(2)-3,4-Q or lactoperoxidase-oxidized 4-OHE 2 (87 microM final concentration) was incubated with calf-thymus DNA and one of the antioxidants at different ratios (1:0, 1:0.3, 1:1, and 1:3 with respect to E(2)-3,4-Q or 4-OHE2) at 37 degrees C. After 10 h, the DNA was precipitated, and the supernatant was analyzed by using ultraperformance liquid chromatography/tandem mass spectrometry (LC/MS/MS). As anticipated, resveratrol and melatonin did not affect the formation of the depurinating adducts when E(2)-3,4-Q was reacted with DNA in their presence. On the other hand, NAcCys and lipoic acid (reduced form) showed a significant inhibition of the formation of the depurinating adducts by E(2)-3,4-Q. With reaction of lactoperoxidase-activated 4-OHE2 with DNA, resveratrol achieved the highest level of inhibition, NAcCys and reduced lipoic acid produced moderate inhibition, and melatonin had the least inhibition. These results demonstrate that all four selected compounds can inhibit the formation of depurinating estrogen-DNA adducts and set the stage for studies of their ability to inhibit adduct formation and malignant transformation in mammary epithelial cells. This approach is highly useful for identifying agents to prevent the initiation of human cancers, especially breast and prostate cancer. 相似文献
40.
Ramchandra D. Gaikwad Md Liyaqat Ahmed Md Saifuddin Khalid 《Pharmaceutical biology》2013,51(7):592-597
The ethanol extract and saponin mixture of Madhuca longifolia L. (Sapotaceae) were evaluated for anti- inflammatory activity using acute (carrageenan-induced inflammation), sub-acute (formaldehyde-induced inflammation), and chronic (cotton pellet granuloma) models of inflammation in rats. Saponins alone seem to be responsible for the anti-inflammatory activity in the studied models. MLEE (Madhuca longifolia ethanol extract) at a dose level of 10 and 15?mg/kg and Madhuca longifolia saponin mixture (MLSM) at a dose level of 1.5 and 3?mg/kg significantly reduced the edema induced by carrageenan in acute model of inflammation, inhibiting both phases of inflammation. Both the extracts had a more effective response than the reference drug diclofenac sodium in the sub-acute inflammation model. Results indicated a significant anti-inflammatory activity by M. longifolia saponins in cotton pellet granuloma. 相似文献