全文获取类型
收费全文 | 1298篇 |
免费 | 77篇 |
国内免费 | 5篇 |
专业分类
耳鼻咽喉 | 26篇 |
儿科学 | 71篇 |
妇产科学 | 33篇 |
基础医学 | 183篇 |
口腔科学 | 92篇 |
临床医学 | 83篇 |
内科学 | 351篇 |
皮肤病学 | 30篇 |
神经病学 | 72篇 |
特种医学 | 46篇 |
外科学 | 128篇 |
综合类 | 7篇 |
一般理论 | 1篇 |
预防医学 | 133篇 |
眼科学 | 13篇 |
药学 | 72篇 |
中国医学 | 4篇 |
肿瘤学 | 35篇 |
出版年
2023年 | 12篇 |
2022年 | 18篇 |
2021年 | 37篇 |
2020年 | 23篇 |
2019年 | 28篇 |
2018年 | 28篇 |
2017年 | 28篇 |
2016年 | 24篇 |
2015年 | 29篇 |
2014年 | 48篇 |
2013年 | 54篇 |
2012年 | 89篇 |
2011年 | 123篇 |
2010年 | 59篇 |
2009年 | 46篇 |
2008年 | 69篇 |
2007年 | 71篇 |
2006年 | 51篇 |
2005年 | 62篇 |
2004年 | 58篇 |
2003年 | 45篇 |
2002年 | 40篇 |
2001年 | 32篇 |
2000年 | 28篇 |
1999年 | 23篇 |
1998年 | 18篇 |
1997年 | 13篇 |
1996年 | 17篇 |
1995年 | 10篇 |
1994年 | 18篇 |
1993年 | 16篇 |
1992年 | 16篇 |
1991年 | 11篇 |
1990年 | 19篇 |
1989年 | 16篇 |
1988年 | 14篇 |
1987年 | 12篇 |
1986年 | 8篇 |
1985年 | 12篇 |
1984年 | 4篇 |
1983年 | 3篇 |
1982年 | 3篇 |
1981年 | 4篇 |
1979年 | 5篇 |
1976年 | 5篇 |
1975年 | 5篇 |
1972年 | 5篇 |
1969年 | 7篇 |
1966年 | 2篇 |
1939年 | 2篇 |
排序方式: 共有1380条查询结果,搜索用时 281 毫秒
61.
Deborah Carvalho Malta Márcio Dênis Medeiros Mascarenhas Denise Lopes Porto Sandhi Maria Barreto Otaliba Libanio de Morais Neto 《Revista de saúde pública》2014,48(1):52-62
OBJECTIVE
To describe the prevalence of alcohol consumption among adolescent school students and identify its individual and contextual associated factors.METHODS
The present research used data from the 2009 National School Health Survey (PeNSE), which included a sample of 59,699 9th grade students in Brazilian capitals and the Federal District. The association between regular alcohol consumption and independent explanatory variables was measured by means of the Pearson’s Chi-square test, with a 0.05 significance level. The explanatory variables were divided into four groups based on affinity (sociodemographic; school and family context; risk factors; and protection factors). A multivariate analysis was carried out for each group, always adjusting for age and sex. Variables with p < 0.10 were used in the final multivariate analysis model.RESULTS
The highest alcohol consumption in the preceding 30 days was independently associated with pupils aged 15 years (OR = 1.46) and over, female (OR = 1.72), white, children of mothers with higher education, studying in private school, students who had tried smoking (OR = 1.72) and drug use (OR = 1.81), with regular tobacco consumption (OR = 2.16) and those who have had sexual intercourse (OR = 2.37). The factors related to family were skipping school without parental knowledge (OR = 1.49), parents not knowing what children do in their free time (OR = 1.34), having fewer meals with their parents (OR = 1.22), reporting that parents do not care (OR = 3.05), or care little (OR = 3.39) if they go home drunk, and having suffered domestic violence (OR = 1.36).CONCLUSIONS
The results reinforce the importance of viewing alcohol consumption among adolescents as a complex, multifactorial and socially determined phenomenon. 相似文献62.
Ângela C. Crespo Bruno Silva Liliana Marques Erica Marcelino Carolina Maruta Sónia Costa Ângela Timóteo Arminda Vilares Frederico Simões Couto Paula Faustino Ana Paula Correia Ana Verdelho Graça Porto Manuela Guerreiro Ana Herrero Cristina Costa Alexandre de Mendonça Luciana Costa Madalena Martins 《Neurobiology of aging》2014
63.
Thiago Santos Ferreira Manuella Lanzetti Marina Valente Barroso Carlos Romualdo Rueff-Barroso Cláudia Farias Benjamim Lycia de Brito-Gitirana Luís Cristóvão Porto Samuel Santos Valença 《Inflammation》2014,37(5):1355-1365
Our aim was to investigate the effects of four different statins on acute lung inflammation induced by cigarette smoke (CS). C57BL/6 male mice were divided into a control group (sham-smoked) and mice exposed to CS from 12 cigarettes/day for 5 days. Mice exposed to CS were grouped and treated with vehicle (i.p.), atorvastatin (10 mg/kg), pravastatin (10 mg/kg), rosuvastatin (5 mg/kg), or simvastatin (20 mg/kg). Treatment with statins differentially improved the pulmonary response when compared to the CS group. Atorvastatin and pravastatin demonstrated slightly effects on inflammation and oxidative stress. Rosuvastatin demonstrated the best anti-inflammatory effect, whereas simvastatin demonstrated the best antioxidant response. 相似文献
64.
Patricia Araujo ;Giovana Goncalves ;Flavia Latini ;Orlando Ferreira ;Luis Cristovao Porto ;Jose Augusto Barreto ;Manoel Joao Castelo Girao ;Ricardo Sobhie Diaz 《Cellular & molecular immunology》2014,11(6):609-612
BRIEF REPORT The activity of natural killer (NK) cells is partially regulated by killer cell immunoglobulin-like receptors (KIRs) interacting with human leukocyte antigen C (HLA-C) ligands.1 The ligands of several inhibitory (2DL and 3DL) and activating (2DS and 3DS) KIR have been described. 相似文献
65.
Alessandro Ferrari Jacinto Sonia Maria Dozzi Brucki Claudia Sellitto Porto Milton de Arruda Martins Ricardo Nitrini 《Clinics (S?o Paulo, Brazil)》2014,69(3):194-197
OBJECTIVES:
Cognitive impairment in the elderly is frequently overlooked by general practitioners. The use of subjective memory complaints as a sign of cognitive impairment by the general practice is controversial.METHODS:
Elderly individuals (N = 248) were asked whether they had memory complaints and underwent a cognitive impairment screening. Subjects classified as exhibiting “probable cognitive impairment” underwent a complete cognitive evaluation, and the final diagnoses were established by expert consensus.RESULTS:
A total of 147 patients presented with subjective memory complaints, and 43 were further classified as demented or “cognitively impaired not demented”. Subjective memory complaints presented a sensitivity of 100% and a negative predictive value of 100%.CONCLUSION:
Subjective memory complaints are an indicator for cognitive impairment screening. 相似文献66.
67.
Candida albicans Adherence to Denture Base Material: Chemical Disinfection and the Effect of Acquired Salivary Pellicle Formation
下载免费PDF全文
![点击此处可从《Journal of prosthodontics》网站下载免费的PDF全文](/ch/ext_images/free.gif)
68.
Takashi Ando Yuichi Riku Akio Akagi Hiroaki Miyahara Mitsuaki Hirano Toshimasa Ikeda Hiroyuki Yabata Ryuichi Koizumi Chisato Oba Saori Morozumi Keizo Yasui Atsuko Goto Taiji Katayama Satoko Sakakibara Ikuko Aiba Motoko Sakai Masaaki Konagaya Keiko Mori Yasuhiro Ito Hiroyuki Yuasa Masayo Nomura Kristine Joyce L. Porto Jun Mitsui Shoji Tsuji Maya Mimuro Yoshio Hashizume Masahisa Katsuno Yasushi Iwasaki Mari Yoshida 《Brain pathology (Zurich, Switzerland)》2022,32(1):e13002
The striatonigral and olivopontocerebellar systems are known to be vulnerable in multiple system atrophy (MSA), showing neuronal loss, astrogliosis, and alpha-synuclein-immunoreactive inclusions. MSA patients who displayed abundant neuronal cytoplasmic inclusions (NCIs) in the regions other than the striatonigral or olivopontocerebellar system have occasionally been diagnosed with variants of MSA. In this study, we report clinical and pathologic findings of MSA patients characterized by prominent pathologic involvement of the hippocampus. We assessed 146 consecutively autopsied MSA patients. Semi-quantitative analysis of anti-alpha-synuclein immunohistochemistry revealed that 12 of 146 patients (8.2%) had severe NCIs in two or more of the following areas: the hippocampal granule cells, cornu ammonis areas, parahippocampal gyrus, and amygdala. In contrast, the remaining 134 patients did not show severe NCIs in any of these regions. Patients with severe hippocampal involvement showed a higher representation of women (nine women/three men; Fisher's exact test, p = 0.0324), longer disease duration (13.1 ± 5.9 years; Mann–Whitney U-test, p = 0.000157), higher prevalence of cognitive impairment (four patients; Fisher's exact test, p = 0.0222), and lower brain weight (1070.3 ± 168.6 g; Mann–Whitney U-test, p = 0.00911) than other patients. The hippocampal granule cells and cornu ammonis area 1/subiculum almost always showed severe NCIs. The NCIs appeared to be ring-shaped or neurofibrillary tangle-like, fibrous configurations. Three of 12 patients also had dense, round-shaped NCIs that were morphologically similar to pick bodies. The patients with Pick body-like inclusions showed more severe atrophy of the medial temporal lobes and broader spreading of NCIs than those without. Immunohistochemistry for hyperphosphorylated tau and phosphorylated TDP-43 revealed minimal aggregations in the hippocampus of the hippocampal MSA patients. Our observations suggest a pathological variant of MSA that is characterized by severe involvement of hippocampal neurons. This phenotype may reinforce the importance of neuronal alpha-synucleinopathy in the pathogenesis of MSA. 相似文献
69.
70.
Elizabeth M.F.L. Domingues Teresa Matuck Miguel L. Graciano Edison Souza Suzimar Rioja Mônica C. Falci Deise B. Monteiro de Carvalho Luís Cristóvão Porto 《Clinical transplantation》2010,24(6):821-829
Domingues EMFL, Matuck T, Graciano ML, Souza E, Rioja S, Falci MC, Monteiro de Carvalho DB, Porto LC. Panel reactive HLA antibodies, soluble CD30 levels, and acute rejection six months following renal transplant. Clin Transplant 2010: 24: 821–829. © 2009 John Wiley & Sons A/S. Abstract: Background: Specific anti‐human leukocyte antigen antibodies (HLA) in the post‐transplant period may be present with acute rejection episodes (ARE), and high soluble CD30 (sCD30) serum levels may be a risk factor for ARE and graft loss. Methods: HLA cross‐matching, panel reactive antibodies (PRA), and sCD30 levels were determined prior to transplantation in 72 patients. Soluble CD30 levels and PRA were re‐assessed at day 7, 14, 21, and 28, and monthly up to the sixth. Results: Twenty‐four subjects had a positive PRA and 17 experienced ARE. Nine of 17 ARE subjects demonstrated positive PRA and 16 had HLA mismatches. Positive PRA was more frequent in ARE subjects (p = 0.03). Eight subjects with ARE had donor‐specific antibodies (DSA) in serum samples pre‐transplantation, two subjects developed DSA. Three subjects without ARE had positive PRA only in post‐transplantation samples. Soluble CD30 levels were higher in pre‐transplant samples and ARE subjects than non‐ARE subjects (p = 0.03). Post‐transplant sCD30 levels were elevated in subjects who experienced rejection and were significantly higher at seven d (p = 0.0004) and six months (p = 0.03). Conclusions: Higher sCD30 levels following transplant were associated with ARE. Elevated sCD30 levels may represent a risk factor for acute rejection. 相似文献