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991.
Skare TL Bortoluzzo AB Gonçalves CR Braga da Silva JA Ximenes AC Bértolo MB Ribeiro SL Keiserman M Menin R Carneiro S Azevedo VF Vieira WP Albuquerque EN Bianchi WA Bonfiglioli R Campanholo C Carvalho HM Costa IP Duarte AP Gavi MB Kohem CL Leite NH Lima SA Meirelles ES Pereira IA Pinheiro MM Polito E Resende GG Rocha FA Santiago MB Sauma Mde F Sampaio-Barros PD 《The Journal of rheumatology》2012,39(1):141-147
992.
Fernanda Lima-Setta Maria Clara de Magalhães-Barbosa Gustavo Rodrigues-Santos Elaine Augusta das Neves Figueiredo Melissa de Lorena Jacques Raquel de Seixas Zeitel Roberto Sapolnik Cibelle Teixeira da Siva Borges Vanessa Soares Lanziotti Roberta Esteves Vieira de Castro Ana Paula Novaes Bellinat Thiago Peres da Silva Felipe Rezende Caino de Oliveira Bárbara Carvalho Santos dos Reis Natália Almeida de Arnaldo Silva Rodriguez Castro João Henrique Garcia Cobas Macedo Ana Carolina Cabral Pinheiro Scarlato Paula Marins Riveiro Arnaldo Prata-Barbosa 《Jornal de pediatria》2021,97(3):354-361
ObjectiveTo describe the clinical, laboratory, and radiological characteristics, as well as the outcomes of children with MIS-C.MethodMulticenter, prospective cohort study, conducted in 17 pediatric intensive care units in five states in Brazil, from March to July 2020. Patients from 1 month to 19 years who met the MIS-C diagnostic criteria were included consecutively.ResultsFifty-six patients were included, with the following conditions: Kawasaki-like disease (n = 26), incomplete Kawasaki disease (n = 16), acute cardiac dysfunction (n = 10), toxic shock syndrome (n = 3), and macrophage activation syndrome (n = 1). Median age was 6.2 years (IQR 2.4?10.3), 70% were boys, 59% were non-whites, 20% had comorbidities, 48% reported a contact with COVID-19 cases, and 55% had a recent SARS-CoV-2 infection confirmed by RT-PCR and/or serology. Gastrointestinal symptoms were present in 71%, shock symptoms in 59%, and severe respiratory symptoms in less than 20%. d-Dimer was increased in 80% and cardiac dysfunction markers in more than 75%. Treatment included immunoglobulin (89%); corticosteroids, antibiotics, and enoxaparin in about 50%; and oseltamivir and antifungal therapy in less than 10%. Only 11% needed invasive mechanical ventilation, with a median duration of five days (IQR 5–6.5). The median length of PICU stay was six days (IQR 5–11), and one death occurred (1.8%).ConclusionsMost characteristics of the present MIS-C patients were similar to that of other cohorts. The present results may contribute to a broader understanding of SARS-CoV-2 infection in children and its short-term consequences. Long-term multidisciplinary follow-up is needed, since it is not known whether these patients will have chronic cardiac impairment or other sequelae. 相似文献
993.
Nourin Ali Sherif Mostafa Ebraheem Morra Le Van Thanh Ghadeer Gamal Elsayed Aya Hesham Elkady Abdelrahman Elshafay Nguyen Dang Kien Ahmed AL‐HABBAA Le Huu Nhat Minh Mai Nhu Y Thai Le Ba Nghia Abdelrhman Tarek Mohammed Peter Samuel Eid Tarek Turk Kenji Hirayama Nguyen Tien Huy 《Journal of evaluation in clinical practice》2020,26(3):842-851
994.
Rebecca L. Siegel MPH Stacey A. Fedewa MPH Kimberly D. Miller MPH Ann Goding‐Sauer MPH Paulo S. Pinheiro MD PhD Dinorah Martinez‐Tyson PhD MPH MA Ahmedin Jemal DVM PhD 《CA: a cancer journal for clinicians》2015,65(6):457-480
Cancer is the leading cause of death among Hispanics/Latinos, who represent the largest racial/ethnic minority group in the United States, accounting for 17.4% (55.4 million/318 million) of the total US population in 2014. Every 3 years, the American Cancer Society reports on cancer statistics for Hispanics based on incidence data from the National Cancer Institute, the Centers for Disease Control and Prevention, and the North American Association of Central Cancer Registries and mortality data from the National Center for Health Statistics. Among Hispanics in 2015, there will be an estimated 125,900 new cancer cases diagnosed and 37,800 cancer deaths. For all cancers combined, Hispanics have 20% lower incidence rates and 30% lower death rates compared with non‐Hispanic whites (NHWs); however, death rates are slightly higher among Hispanics during adolescence (aged 15‐19 years). Hispanic cancer rates vary by country of origin and are generally lowest in Mexicans, with the exception of infection‐associated cancers. Liver cancer incidence rates in Hispanic men, which are twice those in NHW men, doubled from 1992 to 2012; however, rates in men aged younger than 50 years declined by 43% since 2003, perhaps a bellwether of future trends for this highly fatal cancer. Variations in cancer risk between Hispanics and NHWs, as well as between subpopulations, are driven by differences in exposure to cancer‐causing infectious agents, rates of screening, and lifestyle patterns. Strategies for reducing cancer risk in Hispanic populations include increasing the uptake of preventive services (eg, screening and vaccination) and targeted interventions to reduce obesity, tobacco use, and alcohol consumption. CA Cancer J Clin 2015;65:457–480 . © 2015 American Cancer Society. 相似文献
995.
The effects of cancer and racial disparities in health‐related quality of life among older Americans: A case‐control,population‐based study
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996.
R.S. Pinheiro V. Rocha-SantosR.A. Pecora R.A. MacedoL.S. Nacif W. AndrausA.I. David C.A. PantanaliC.M. Benites L.A.C. d'Albuquerque 《Transplantation proceedings》2014
Background
Pancreas transplantation is a treatment for advanced type 1 diabetes and offers significant improvement in quality of life. Recent advances in surgical techniques and immunosuppression regimes lead to good outcomes. However, despite significant higher rates of multiorgan donors in Brazil, pancreas transplantation seems to have remained stable. This study aimed to investigate the acceptance rate of potential pancreas donors in the past 10 years in São Paulo State.Methods
We retrospectively evaluated potential pancreas donors characteristics and its acceptance rate in São Paulo State in the past 10 years. We divided this period into 2 eras: 1st era from January 2003 to January 2008; and 2nd era from January 2008 to January 2013. Data were obtained from São Paulo's government official website.Results
During the whole period, 5,005 deceased donors of all ages were available for pancreas transplantation. According to eras, we had 1,588 donors in the 1st and 3,417 in the 2nd era. In the 2nd era, donors >49 years old were significantly more common (P < .001). Blood test abnormalities, donor comorbidities, and high dosage of vasopressors also were significantly higher in the 2nd era. Rate of graft acceptance had a significant decrease in the 2nd era, from 46.4% to 25% (P < .05).Conclusions
Despite greater organ availability, pancreas transplantations performed in São Paulo State remained stable. Rate of graft acceptance is dramatically lower in more recent years. 相似文献997.
Renato Aparecido de Souza Murilo Xavier Nilton Maciel Mangueira Ana Paula Santos Antonio Luiz Barbosa Pinheiro Antonio Balbin Villaverde Landulfo Silveira Jr. 《Lasers in medical science》2014,29(2):797-804
The aim of the present study was to evaluate the feasibility of applying Raman spectroscopy in probing the molecular changes in terms of collagen deposition and tissue remodeling associated with two well-established experimental models of osteoarthritis (OA) in knee of rats. In order to evaluate alterations in the articular surface area, the menisci-covered tibial region was assessed into three groups as follows: control (joint preserved) and two models of experimental knee OA: collagenase-induced model (n?=?8) and treadmill exercise-induced model (n?=?8). Each group was examined for molecular changes using spectral parameters related to cartilage, subchondral bone, and bone tissues. A significant increase of Raman ratios related to mineralization and tissue remodeling was found (p?<?0.05), suggesting that both models were successful for inducing OA in rats. The significantly lower phenylalanine content and higher crystallinity in the treadmill exercise-induced model of OA than collagenase-induced model of OA (p?<?0.05) indicated that the OA pathogenesis was model-dependent. Thus, this work suggests that the Raman spectroscopy technique has potential for the diagnosis and detection of cartilage damage and monitoring of subchondral bone and bone in OA pathogenesis at the molecular level. 相似文献
998.
Jouber Mateus dos Santos Aciole Isabele Cardoso Vieira de Castro Luiz Guilherme Pinheiro Soares Artur Felipe Santos Barbosa Gilberth Tadeu dos Santos Aciole Landulfo Silveira Jr. Antonio L. B. Pinheiro 《Lasers in medical science》2014,29(3):1269-1277
Osteoporosis is a disease characterized by the reduction of bone mineral density. LED wavelengths seem to have similar photo-stimulating effects to laser light. The aim of this study was to assess the Raman shifts: ~960 (phosphate hydroxyapatite), ~1,070 (carbonate hydroxyapatite), and ~1,454 cm ?1 (lipids and proteins) on bone defects of ovariectomized rats treated or not with LED phototherapy (LED-PT). Thirty female rats were divided into four groups (Basal, OVX, OVX+Clot, and OVX+Clot+LED), then subdivided into two subgroups (15 and 30 days after surgery). Osteoporosis induction by ovariectomy (OVX) was performed in all groups, except for the normal basal group. Following development of osteoporosis, one surgical bone defect (5 mm2) was created on the femur of each animal. Defects were irradiated with LED light (λ?=?850?±?10 nm, P?=?150 mW, CW, Ф?=?0.5 cm2, 20.4 J/cm2 per session, t?=?128 s, 163.2 J/cm2 per treatment) at 48 h interval during 2 weeks. Raman measurements were taken at the surface of the defects 30 days after surgery. Significant difference between groups Basal, OVX+Clot, and OVX+Clot+LED for the peaks at ~960 (p?≤?0.001; 15 and 30 days), ~1,070 (p?≤?0.001; 15 and 30 days), and ~1,450 cm?1 (p?=?0.002; 15 days; p?=?0.004; 30 days) were detected. In addition, statistical differences were obtained between groups OVX, OVX+Clot, and OVX+Clot+LED for these same peaks at all time points (p?≤?0.001). At 15 and 30 days, there were statistical differences between groups OVX+Clot and OVX+Clot+LED for the peaks at ~960 (p?≤?0.001), ~1,070 (p?≤?0.001; p?=?0.003), and ~1,450 cm?1 (p?≤?0.001; p?=?0.002). The results of this study are indicative that infrared LED-PT improved the deposition of HA on bone defects of ovariectomized rats. 相似文献
999.
Renato Micelli Lupinacci Evandro Sobrosa Mello Rafael S. Pinheiro Gilton Marques Fabrício Ferreira Coelho Jaime Arthur Pirolla Kruger Marcos Vinícius Perini Paulo Herman 《World journal of surgery》2014,38(8):2089-2096
Background
Despite advances in diagnosis and surgical strategies, up to 70 % of patients will develop recurrence of the disease after resection of colorectal cancer liver metastases (CRCLM). The purpose of our study was to determine the frequency of four different mechanisms of intrahepatic dissemination, and to evaluate the impact of each mechanism on patient outcomes.Methods
The medical records of 118 patients who underwent a first resection of CRCLM during the period between 2000 and 2010 were reviewed. Clinicopathologic variables and outcome parameters were examined. Resected specimens were submitted to routine histological evaluation, and immunohistochemical staining with D2-40 (lymphatic vessels), CD34 (blood vessels), CK-7 (biliary epithelium), and CK-20 (CRC cells).Results
The mean follow-up after resection was 38 months. Tumor recurrence was observed in 76 patients, with a median interval of 13 months after resection. Overall survival and disease-free survival (DFS) rates after hepatectomy were 62 and 56 %, and 26 and 24 % at 3 and 5 years, respectively. Intrahepatic microscopic invasion included portal venous in 49 patients, sinusoidal in 43 patients, biliary in 20 patients, and lymphatic in 33 patients. Intra-hepatic lymphatic invasion was the only mechanism of dissemination independently associated with the risk of hepatic recurrence (odds ratio 2.75) and shorter DFS (p = 0.006).Conclusion
Intrahepatic lymphatic invasion is a significant prognostic factor. Other mechanisms of invasion, although frequently observed, are not related to recurrence or survival, suggesting that the lymphatic system is the main route for dissemination of CRCLM. Furthermore, immunohistochemical detection of intrahepatic lymphatic invasion might be of value in clinical practice. 相似文献1000.
Joana C. M. Narvaez Karen Jansen Ricardo T. Pinheiro Flávio Kapczinski Ricardo A. Silva Flávio Pechansky Pedro V. S. Magalhães 《Social psychiatry and psychiatric epidemiology》2014,49(8):1249-1255