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81.
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PL Macken FRACO FRACS SR Boyd MD I Campbell MD CRCP DipBact † D Chang MSc † DS Rootman MD FRCS GE Trope PhD FRCS 《Clinical & experimental ophthalmology》1995,23(4):323-325
Background: Haemophilus aphrophilus is a rare cause of ocular infection. It has been reported once as a cause of late-onset endophthalmitis in a patient with an inadvertent bleb after cataract surgery. We present a case of Haemophilus aphrophilus bleb infection after a mitomycin trabeculectomy.
Methods: A 56-year-old woman presented with a bleb infection 10 weeks after a mitomycin C augmented trabeculectomy at a University tertiary referral practice of one of the authors (GET). The causative organism was Haemophilus aphrophilus , identified by the Toronto Public Health Laboratory, Ontario, Canada.
Results: The bleb infection resolved following topical, subconjunctival and intravenous antibiotic therapy. A formal bleb revision was required to repair a persistent bleb leak.
Conclusion: Patients who have had trabeculectomies augmented with mitomycin C may be predisposed to bleb infection with unusual organisms. Prompt diagnosis and treatment is necessary to control the infection. Increased awareness and communication with laboratory personnel may increase the isolation of this fastidious organism. 相似文献
Methods: A 56-year-old woman presented with a bleb infection 10 weeks after a mitomycin C augmented trabeculectomy at a University tertiary referral practice of one of the authors (GET). The causative organism was Haemophilus aphrophilus , identified by the Toronto Public Health Laboratory, Ontario, Canada.
Results: The bleb infection resolved following topical, subconjunctival and intravenous antibiotic therapy. A formal bleb revision was required to repair a persistent bleb leak.
Conclusion: Patients who have had trabeculectomies augmented with mitomycin C may be predisposed to bleb infection with unusual organisms. Prompt diagnosis and treatment is necessary to control the infection. Increased awareness and communication with laboratory personnel may increase the isolation of this fastidious organism. 相似文献
84.
Modulation of implantation-associated integrin expression but not uteroglobin by steroid hormones in an endometrial cell line 总被引:2,自引:0,他引:2
Widra EA; Weeraratna A; Stepp MA; Stillman RJ; Patierno SR 《Molecular human reproduction》1997,3(7):563-568
In order to test the hypothesis that integrin and uteroglobin (UG)
expression in cultured endometrial cells are affected by hormone treatment,
Ishikawa-CH endometrial cancer cells were cultured and exposed to
oestradiol or oestradiol and progesterone regimens and assayed using
immunohistochemistry. We evaluated the intensity of immunohistochemical
staining for the integrin monomers alpha(v) and beta1, the dimers
alpha(v)beta3 and alpha(v)beta6, and for the secretory protein uteroglobin
under various experimental conditions. Cells grown in control media stained
positively for the integrin monomers alpha(v) and beta1, the dimer
alpha(v)beta3, and for UG. Oestradiol and sequential
oestradiol/progesterone reversibly suppressed staining for the dimer
alpha(v)beta3. Hormone treatment had no effect on the staining of the beta1
and alpha(v) monomers or UG. The alpha(v)beta6 dimer antibody did not stain
under any experimental treatment conditions. These data indicate that
expression of the integrin complex alpha(v)beta3 is reversibly suppressed
by oestradiol in Ishikawa cells and that these cells may be a good model
for studying hormone-driven molecular changes in endometrium.
相似文献
85.
86.
Raphael Sharon Graciela Pillemer Dvorah Ish-Shalom Rony Kalman Ehud Ziv Elliot M. Berry David Naor 《International journal of cancer. Journal international du cancer》1993,53(5):843-849
Physiological concentrations of insulin support the in vitro growth of LB T-cell lymphoma. We could not detect similar insulin dependence in other tumor cell lines. This study reports that insulin also enhances the growth of LB cells in vivo. Mice treated with Streptozotocin (SZ) developed partial resistance to LB lymphoma growth and they survived longer (p < 0.0025) than non-diabetic mice after LB-cell inoculation. A few diabetic mice developed complete tumor resistance, manifested by total regression of the lymphoma. SZ-treated diabetic mice reconstituted with external insulin died as fast as non-diabetic mice when both were inoculated with the same number of LB cells. The SZ-treated diabetic mice did not develop resistance to the growth of BCLI B-cell leukemia, which demonstrated only a marginal proliferative response to insulin in vitro. Mice fed a low-energy diet exhibited low insulin levels and also developed resistance to lymphoma growth (50% survival 21 days vs. 15 days; p < 0.0005), supporting the concept that insulin enhances LB T-cell tumor development in mice. 相似文献
87.
88.
Rosen T Lachs MS Bharucha AJ Stevens SM Teresi JA Nebres F Pillemer K 《Journal of the American Geriatrics Society》2008,56(8):1398-1408
OBJECTIVES: To more fully characterize the spectrum of resident‐to‐resident aggression (RRA). DESIGN: A focus group study of nursing home staff members and residents who could reliably self‐report. SETTING: A large, urban, long‐term care facility. PARTICIPANTS: Seven residents and 96 staff members from multiple clinical and nonclinical occupational groups. MEASUREMENTS: Sixteen focus groups were conducted. Content was analyzed using nVivo 7 software for qualitative data. RESULTS: Thirty‐five different types of physical, verbal, and sexual RRA were described, with screaming or yelling being the most common. Calling out and making noise were the most frequent of 29 antecedents identified as instigating episodes of RRA. RRA was most frequent in dining and residents' rooms, and in the afternoon, although it occurred regularly throughout the facility at all times. Although no proven strategies exist to manage RRA, staff described 25 self‐initiated techniques to address the problem. CONCLUSION: RRA is a ubiquitous phenomenon in nursing home settings, with important consequences for affected individuals and facilities. Further epidemiological research is necessary to more fully describe the phenomenon and identify risk factors and preventative strategies. 相似文献
89.
Oral health and dental morbidity in long‐term allogeneic blood and marrow transplant survivors in Australia
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90.
Brunner G; Metz CN; Nguyen H; Gabrilove J; Patel SR; Davitz MA; Rifkin DB; Wilson EL 《Blood》1994,83(8):2115-2125
Basic fibroblast growth factor (bFGF) is a hematopoietic cytokine that stimulates stromal and stem cell growth. It binds to a glycosylphosphatidylinositol (GPI)-anchored heparan sulfate proteoglycan on human bone marrow (BM) stromal cells. The bFGF- proteoglycan complex is biologically active and is released by addition of exogenous phosphatidylinositol-specific phospholipase C. In this study, we show the presence of an endogenous GPI-specific phospholipase D (GPI-PLD) that releases the bFGF-binding heparan sulfate proteoglycan and the variant surface glycoprotein (a model GPI-anchored protein) from BM cultures. An involvement of proteases in this process is unlikely, because released proteoglycan contained the GPI anchor component, ethanol-amine, and protease inhibitors did not diminish the release. The mechanism of release is likely to involve a GPI-PLD and not a GPI-specific phospholipase C, because the release of variant surface glycoprotein did not reveal an epitope called the cross- reacting determinant that is exposed by phospholipase C-catalyzed GPI anchor cleavage. In addition, phosphatidic acid (which is specifically a product of GPI-PLD-catalyzed anchor cleavage) was generated during the spontaneous release of the GPI-anchored variant surface glycoprotein. We also detected GPI-PLD-specific enzyme activity and mRNA in BM cells. Therefore, we conclude that an endogenous GPI-PLD releases bFGF-heparan sulfate proteoglycan complexes from human BM cultures. This mechanism of GPI anchor cleavage could be relevant for mobilizing biologically active bFGF in BM. An endogenous GPI-PLD could also release other GPI-anchored proteins important for hematopoiesis and other physiologic processes. 相似文献