全文获取类型
收费全文 | 874篇 |
免费 | 54篇 |
国内免费 | 17篇 |
专业分类
耳鼻咽喉 | 9篇 |
儿科学 | 36篇 |
妇产科学 | 27篇 |
基础医学 | 91篇 |
口腔科学 | 23篇 |
临床医学 | 90篇 |
内科学 | 290篇 |
皮肤病学 | 5篇 |
神经病学 | 56篇 |
特种医学 | 68篇 |
外科学 | 103篇 |
综合类 | 11篇 |
预防医学 | 31篇 |
眼科学 | 5篇 |
药学 | 27篇 |
中国医学 | 1篇 |
肿瘤学 | 72篇 |
出版年
2023年 | 2篇 |
2022年 | 8篇 |
2021年 | 17篇 |
2020年 | 15篇 |
2019年 | 12篇 |
2018年 | 18篇 |
2017年 | 13篇 |
2016年 | 13篇 |
2015年 | 17篇 |
2014年 | 27篇 |
2013年 | 32篇 |
2012年 | 41篇 |
2011年 | 40篇 |
2010年 | 35篇 |
2009年 | 47篇 |
2008年 | 33篇 |
2007年 | 37篇 |
2006年 | 37篇 |
2005年 | 24篇 |
2004年 | 31篇 |
2003年 | 30篇 |
2002年 | 28篇 |
2001年 | 19篇 |
2000年 | 33篇 |
1999年 | 26篇 |
1998年 | 36篇 |
1997年 | 33篇 |
1996年 | 24篇 |
1995年 | 17篇 |
1994年 | 23篇 |
1993年 | 8篇 |
1992年 | 11篇 |
1991年 | 13篇 |
1990年 | 10篇 |
1989年 | 14篇 |
1988年 | 13篇 |
1987年 | 15篇 |
1986年 | 22篇 |
1985年 | 23篇 |
1984年 | 7篇 |
1983年 | 3篇 |
1982年 | 11篇 |
1981年 | 3篇 |
1980年 | 2篇 |
1978年 | 2篇 |
1977年 | 2篇 |
1972年 | 3篇 |
1968年 | 2篇 |
1967年 | 2篇 |
1963年 | 2篇 |
排序方式: 共有945条查询结果,搜索用时 218 毫秒
51.
Cruz RJ Perin D Silva LE Valério FB Branco MC Poli de Figueiredo LF Rocha e Silva M 《Injury》2001,32(1):17-21
Standard-of-care, large volume crystalloid infusion, in the setting of uncontrolled bleeding, has been challenged and it is not known if fluid resuscitation increases retroperitoneal hemorrhage. We developed an experimental model of retroperitoneal haemorrhage to correlate haemodynamic and metabolic alterations with the blood volume loss. Anaesthetised, spontaneously breathing dogs (17.1+/-0.56 kg) were randomised to unilateral (UL, n=11) or bilateral (BL, n=11) iliac artery puncture, using a metallic device introduced through the femoral arteries and followed for 120 min. Initial and final blood volumes were determined using radioactive tracers, 99mTC and 51Cr, respectively. UL was associated with a stable arterial pressure and a moderate decrease in cardiac output and oxygen delivery. BL induced an abrupt and sustained decrease in mean arterial pressure, from 131.9+/-5.9 to 88.6+/-10.8 mmHg, and a much greater reduction in cardiac output, oxygen delivery and consumption than UL throughout the experiment. Total retroperitoneal blood loss after BL was 36.8+/-3.2 ml/kg, while after UL was 25.1+/-3.4 ml/kg (P=0.0262). We conclude that a transfemoral bilateral iliac artery puncture produces a clinically relevant model of uncontrolled retroperitoneal haemorrhage, with hypotension and low flow state, while a unilateral iliac artery lesion causes a compensated shock state. 相似文献
52.
Biagini R Ruggieri P Briccoli A Fasano D Montanari FM Gamberini G Perin S Mercuri M 《La Chirurgia degli Organi di Movimento》2001,86(1):1-5
The authors describe the method used to reconstruct the posterior wall of the pelvis using a flap taken from the rectus abdominis muscle after resection of the sacrum to treat neoplasm. 相似文献
53.
54.
55.
Objective : To review experience of CYP11β1 deficiency (previously known as 11β-hydroxylase) at the Royal Children's Hospital, Melbourne, Victoria.
Methodology : A retrospective case review was conducted from 1974 to 1995 with five cases identified.
Results : Age of presentation ranged from 1 day to 7 years. Presentation was with ambiguous genitatia at birth (two females), simple virilization (two males) and suspected early puberty in mid childhood (one female). Associated clinical features were hypertension (three cases) and tall stature with markedly advanced bone age (four cases). Biochemical abnormalities consistent with CYP11β1-deficiency were elevated urinary tetrahydro-11-deoxycortisol ( n = 5) and elevated serum 11-deoxycortisol ( n = 3). Additional abnormalities were elevated 17-hydroxyprogesterone ( n = 3), elevated androstenedione ( n = 4) and elevated dehydroepiandrosterone sulphate ( n = 4). The clinical features and investigations suggested CYP11β1-classical deficiency in four patients and CYP11β1-non-classical deficiency in one patient.
Conclusions : The five cases of CYP11β1-deficiency demonstrate a spectrum of clinical abnormalities, with diagnostic difficulties in two cases and delayed presentation in three cases. Prompt diagnosis of CYP11β1-deficiency is facilitated greatly by the availability of a gas chromatography-mass spectrometry instrument and is essential to avoid the long-term effects of hypertension and hyperandrogenism. 相似文献
Methodology : A retrospective case review was conducted from 1974 to 1995 with five cases identified.
Results : Age of presentation ranged from 1 day to 7 years. Presentation was with ambiguous genitatia at birth (two females), simple virilization (two males) and suspected early puberty in mid childhood (one female). Associated clinical features were hypertension (three cases) and tall stature with markedly advanced bone age (four cases). Biochemical abnormalities consistent with CYP11β1-deficiency were elevated urinary tetrahydro-11-deoxycortisol ( n = 5) and elevated serum 11-deoxycortisol ( n = 3). Additional abnormalities were elevated 17-hydroxyprogesterone ( n = 3), elevated androstenedione ( n = 4) and elevated dehydroepiandrosterone sulphate ( n = 4). The clinical features and investigations suggested CYP11β1-classical deficiency in four patients and CYP11β1-non-classical deficiency in one patient.
Conclusions : The five cases of CYP11β1-deficiency demonstrate a spectrum of clinical abnormalities, with diagnostic difficulties in two cases and delayed presentation in three cases. Prompt diagnosis of CYP11β1-deficiency is facilitated greatly by the availability of a gas chromatography-mass spectrometry instrument and is essential to avoid the long-term effects of hypertension and hyperandrogenism. 相似文献
56.
Fabrice Perin Laurence Routledge Oumar N'Doye Mamadou M'Bodj Gérard Normier Alain Le Pape 《Nuclear medicine and biology》1996,23(8):947-955
The potential of 99m-Tc-J001 for the investigation of inflammatory lesions via the targeting of recruited macrophages (Mφ) has already been documented in several experimental models and in human diseases. To achieve a functional imaging of inflammation via Mφ targeting, minimal labeled colloid content and high in vivo stability of 99mTc-J001 are essential. The actual specificity of such scintigraphy is closely dependent upon the radiolabeling of only the J001 molecules available for Mφ targeting. To develop an appropriate radiopharmaceutical kit, optimization of the labeling conditions was achieved from a series of pilot formulations that were evaluated for radiolabeling efficiency and both in vitro and in vivo 99mTc-J001 stability. Colloids were characterized using autocorrelation spectroscopy and multiangle laser-light scattering, radioactive colloid content of the formulations being deduced from biodistribution studies. This work has made possible the definition of a formulation exhibiting a radiolabeling yield >97.0%, associated with in vivo stability and minimal colloid formation, thus greatly enhancing the specificity of such macrophage scintigraphy. 相似文献
57.
M. LEA THOMAS F.R.CP. F.R.C.R. H. L. WALTERS D.M.R.D. 《Journal of Medical Imaging and Radiation Oncology》1977,21(4):346-349
The angiographic findings in a patient with haemophilic pseudotumour of the femur are presented. The examination showed the position of the displaced femoro-poplited vessels, enabling these structures to be avoided at operation. Under anti-haemophilic globulin cover no complications occurred. It is suggested that angiography may be safely employed provided the coagulation defect is controlled. The examination may be useful in differentiating other bone lesions and in defining more clearly the extent of a haemophilic pseudotumour. 相似文献
58.
59.
60.
Biagini R Casadei R Favale L Salducca N Erba F Gigli M Boriani S Gamberini G Rocca M Briccoli A Perin S Pelosi M Mercuri M 《La Chirurgia degli Organi di Movimento》2004,89(4):293-298
The authors describe a variation in the method of vertebral hemi-resection used for the treatment of neoplasms that present a wide invasion of the vertebral canal. This is followed by a review of the literature on the subject. 相似文献