全文获取类型
收费全文 | 62969篇 |
免费 | 3405篇 |
国内免费 | 225篇 |
专业分类
耳鼻咽喉 | 581篇 |
儿科学 | 1668篇 |
妇产科学 | 1241篇 |
基础医学 | 8565篇 |
口腔科学 | 889篇 |
临床医学 | 5423篇 |
内科学 | 15710篇 |
皮肤病学 | 1333篇 |
神经病学 | 6426篇 |
特种医学 | 1877篇 |
外国民族医学 | 31篇 |
外科学 | 8469篇 |
综合类 | 120篇 |
一般理论 | 11篇 |
预防医学 | 3730篇 |
眼科学 | 1056篇 |
药学 | 3955篇 |
中国医学 | 98篇 |
肿瘤学 | 5416篇 |
出版年
2023年 | 359篇 |
2022年 | 457篇 |
2021年 | 1259篇 |
2020年 | 750篇 |
2019年 | 1196篇 |
2018年 | 1758篇 |
2017年 | 1311篇 |
2016年 | 1341篇 |
2015年 | 1586篇 |
2014年 | 1914篇 |
2013年 | 2738篇 |
2012年 | 4535篇 |
2011年 | 4480篇 |
2010年 | 2353篇 |
2009年 | 2007篇 |
2008年 | 4037篇 |
2007年 | 4152篇 |
2006年 | 3880篇 |
2005年 | 3941篇 |
2004年 | 3854篇 |
2003年 | 3385篇 |
2002年 | 3313篇 |
2001年 | 1242篇 |
2000年 | 1238篇 |
1999年 | 1041篇 |
1998年 | 430篇 |
1997年 | 332篇 |
1996年 | 323篇 |
1995年 | 295篇 |
1994年 | 234篇 |
1993年 | 219篇 |
1992年 | 631篇 |
1991年 | 547篇 |
1990年 | 546篇 |
1989年 | 495篇 |
1988年 | 454篇 |
1987年 | 440篇 |
1986年 | 395篇 |
1985年 | 374篇 |
1984年 | 304篇 |
1983年 | 222篇 |
1982年 | 149篇 |
1979年 | 176篇 |
1977年 | 119篇 |
1974年 | 133篇 |
1973年 | 119篇 |
1972年 | 119篇 |
1971年 | 125篇 |
1969年 | 133篇 |
1968年 | 114篇 |
排序方式: 共有10000条查询结果,搜索用时 468 毫秒
11.
Dominique Trudel Luminita-Mihaela Avarvarei Michèle Orain Stéphane Turcotte Marie Plante Jean Grégoire Reinhild Kappelhoff David P. Labbé Dimcho Bachvarov Bernard Têtu Christopher M. Overall Isabelle Bairati 《Pathology, research and practice》2019,215(6):152369
Ovarian carcinoma is one of the most lethal malignancies, but only very few prognostic biomarkers are known. The degradome, comprising proteases, protease non-proteolytic homologues and inhibitors, have been involved in the prognosis of many cancer types, including ovarian carcinoma. The prognostic significance of the whole degradome family has not been specifically studied in high-grade serous ovarian cancer. A targeted DNA microarray known as the CLIP-CHIP microarray was used to identify potential prognostic factors in ten high-grade serous ovarian cancer women who had early recurrence (<1.6 years) or late/no recurrence after first line surgery and chemotherapy. In women with early recurrence, we identified seven upregulated genes (TMPRSS4, MASP1/3, SPC18, PSMB1, IGFBP2, CFI – encoding Complement Factor I – and MMP9) and one down-regulated gene (ADAM-10). Using immunohistochemistry, we evaluated the prognostic effect of these 8 candidate genes in an independent cohort of 112 high-grade serous ovarian cancer women. Outcomes were progression, defined according to CA-125 criteria, and death. Multivariate Cox proportional hazard regression models were done to estimate the associations between each protein and each outcome. High ADAM-10 expression (intensity of 2–3) was associated with a lower risk of progression (adjusted hazard ratio (HR): 0.51; 95% confidence interval (CI): 0.29-0.87). High complement factor I expression (intensity 2–3) was associated with a higher risk of progression (adjusted HR: 2.30, 95% CI: 1.17–4.53) and death (adjusted HR: 3.42; 95% CI: 1.72–6.79). Overall, we identified the prognostic value of two proteases, ADAM-10 and complement factor I, for high-grade serous ovarian cancer which could have clinical significance. 相似文献
12.
Marion Tardieu Najat Salameh Line Souris David Rousseau Laurène Jourdain Hanadi Skeif François Prévot Ludovic de Rochefort Denis Ducreux Bruno Louis Philippe Garteiser Ralph Sinkus Luc Darrasse Marie Poirier-Quinot Xavier Maître 《NMR in biomedicine》2022,35(7):e4701
Magnetic resonance elastography aims to non-invasively and remotely characterize the mechanical properties of living tissues. To quantitatively and regionally map the shear viscoelastic moduli in vivo, the technique must achieve proper mechanical excitation throughout the targeted tissues. Although it is straightforward, ante manibus, in close organs such as the liver or the breast, which practitioners clinically palpate already, it is somewhat fortunately highly challenging to trick the natural protective barriers of remote organs such as the brain. So far, mechanical waves have been induced in the latter by shaking the surrounding cranial bones. Here, the skull was circumvented by guiding pressure waves inside the subject's buccal cavity so mechanical waves could propagate from within through the brainstem up to the brain. Repeatable, reproducible and robust displacement fields were recorded in phantoms and in vivo by magnetic resonance elastography with guided pressure waves such that quantitative mechanical outcomes were extracted in the human brain. 相似文献
13.
Viviana Maestrini Lucia I. Birtolo Sara Cimino Paolo Severino Massimo Mancone Marco Francone Sanjay M. Banypersad Flavia Ventriglia Luigi Tritapepe Fabio Miraldi Francesco Fedele 《Echocardiography (Mount Kisco, N.Y.)》2019,36(5):992-995
A 20‐year‐old Congolese woman presented with presyncope, dyspnea, and anasarca. Past medical history was unremarkable. Echocardiography revealed a rare combination of giant right atrium (RA), a dilated and hypertrophied right ventricle, subvalvular pulmonary stenosis (subPS), severe tricuspid regurgitation (TR), pericardial effusion and what appeared to be a spontaneously closed ventricular septal defect (VSD). Cardiac Magnetic Resonance and Cardiac Computed Tomography confirmed the findings excluding the presence of intra‐cardiac and extra‐cardiac shunt and other associated congenital anomalies. The patient underwent subPS resection, right atrioplasty, and tricuspid annuloplasty. Multimodality approach facilitated the detection of the abnormalities and provided clarity when determining the optimal surgical strategy. 相似文献
14.
European Archives of Oto-Rhino-Laryngology - The hypnosis gives more comfort to the patient and can be used in patients at risk of a general anaesthesia. 相似文献
15.
16.
17.
Alessandro Abbouda Paolo Tortorella Lucia Restivo Elisa Santoro Federica De Marco Maurizio La Cava 《Seminars in ophthalmology》2016,31(6):532-541
Purpose: To evaluate the rate and onset of intraoperative and postoperative complications post-phacoemulsification. Methods: One hundred sixty-two eyes of 145 patients with uveitis who underwent phacoemulsification between 2006 and 2009 were identified through surgical record review. Fifty-nine eyes of 46 patients met the inclusion criteria. Hazard ratio (HR) and Kaplan-Meier survival probability were calculated for each class of uveitis. Results: Macular edema (ME) resulted to be associated to chronic postoperative inflammation (r?=?0.6; p?=?0.00) and mostly related to patients who presented more than one postoperative relapse/year (r?=?0.2; p?=?0.02). Fuchs uveitis resulted to be a risk factor for posterior capsule opacification (PCO) (HR 3.36 IC95%1.0-10.5; p?=?0.03). Hypotony and elevated intraocular pressure (IOP) were detected in the anterior uveitis group (0.02 EY). Conclusion: The HR to develop ME was significantly related to chronic anterior uveitis. PCO and elevated IOP are most frequent in Fuchs uveitis. The postoperative visual acuity result was good among all the uveitis groups. 相似文献
18.
19.
20.